AU715783B2 - Process for making monoacetals of hydroquinone - Google Patents

Description

I- 'a r/Vuu I I ~WP Rogulato 3.2(2)

AUSTRALIA

Patents Act 1990

ORIGINAL

COMPLETE SPECIFICATION STANDARD PATENT Application Number: 14272/99 Lodged: 1 FEBRUARY 1999 Invention Title: PROCESS FOR MAKING MONOACETALS OF HYDROQUINONE The following statement Is a full description of this Invention, Including the best method of performing It known to us IPAustralia C Documents received on: E 0 18 MAY 1999 Batch No:F PROCESS FOR MAKING MONOACETALS OF HYDROQUINONE FIELD OF THE INVENTION The present invention is for a process for preparing monoacetals of hydroquinone wherein said process yields higher yields of greater purity than reactions previously used.

BACKGROUND OF THE INVENTION The process for making monoacetals of hydroquinone is disclosed in copending patent application Australian patent Application No. 19399/95 filed on March 1, 1995; incorporated herein by reference. Said process involves reacting equimolar amounts of hydroquinone with enol ethers in the presence of an acid catalyst:

OH

O

H

OH

OH

R OR' R R each R is, independently, selected from the group consisting of hydrogen; C1-Cio alkyl; benzyl, aryl and substituted benzyl or aryl.

(ii) each R' is, independently, selected from the group consisting of C1- Clo alkyl; benzyl, aryl and substituted benzyl or aryl.

(iii) n is an integer from 0 to 3.

However, said reaction has several limitations. For equimolar concentrations of hydroquinone and enol ethers said reaction also results in formation of hydroquinone bis-acetals which are poor skin lightening compounds. Removal of the non-efficacious bis-acetal compounds, along with unreacted hydroquinone, necessitates expensive large scale chromatographic purification such that isolated yield of said monoacetal is poor, typically 30-40%.

Attempts at improving overall yield and cost of process via conversion/recycling of bis-acetal to desired monoacetal is problematic due to similar reactivity of the two compounds, while changing the stoichiometry of the reaction to minimize bis-acetal formation increases the amount of hydroquinone which ultimately needs to be chromatographically removed.

SUMMARY OF THE INVENTION The present invention is a process for preparing monoacetals of hydroquinone comprising the steps of: a) reacting monoethers of hydroquinone with an enol ether in the presence of an acid catalyst to yield the protected monoacetal of hydroquinone as an intermediate; and b) reacting said intermediate with a hydrogen transfer source in the presence of a metal catalyst such that protecting group is selectively cleaved to give desired hydroquinone monoacetal.

These reactions produce purer hydroquinone monoacetals in high yield without the need for chromatographic purification.

DETAILED DESCRIPTION OF THE INVENTION The present invention is a novel process for making hydroquinone monoacetals comprising a series of steps wherein monoethers of hydroquinone are used to improve the purity and the yield of the desired final product compared to the process previously disclosed. Reaction of said hydroquinone monoether with an enol ether yields an intermediate product that is protected from acid catalyzed coupling with a second equivalent of enol ether, irrespective of the stoichiometry of the monoether compound and enol ether. Utilization of protecting groups to eliminate production of undesirable by-products of synthesis reactions is well known in the art. In the present invention it is desirable to eliminate or at the very least minimize producing bis-acetal hydroquinone compounds, which if present at the time of the second process step of the present invention, yields undesirable final products. In the subsequent hydrogenolysis of said intermediate product, selective cleavage of ether protecting group provides the final desired product in higher yields with greater purity.

The hydroquinone protecting groups useful in the present invention are ethers susceptible to selective hydrogenolysis under mild conditions. Said ethers used as protective groups in the present invention are selected from the group consisting of arylmethyl, diarylmethyl, triarylmethyl, trimethylsilyl ethers and mixtures thereof, preferably arylmethyl ethers. The preferred arylmethyl ether protecting groups of the present invention are selected from the group consisting of benzyl, aliphatic benzyl ethers and mixtures thereof, preferably aliphatic benzyl ether, most preferably the monobenzyl ether. The monobenzyl ether of hydroquinone may be purchased as monobenzone or 4- (benzyloxy)phenol directly from commercial sources such as Aldrich Chemical Company and Hoechst Celanese Corporation. Monobenzone may also be produced by routine chemical reactions well known in the art; see Schiff and Pellizzari, Justus Liebig's Annalen Der Chimie. vol. 221, pp370 (1883); incorporated herein by reference.

The said hydroquinone monoether is reacted with cyclic or acyclic enol ethers to yield the protected intermediate, preferably the benzyl protected monoacetal of hydroquinone, as illustrated below: Bn+ Bn R R OBn OBn S R R H+ R

T

OH O OR' R R substituted benzyl or aryl.

R

wherein: each R is, independently, selected from the group consisting of hydrogen; Ci-Cio alkyl; benzyl, aryl and substituted benzyl or aryl.

(ii) each R' is, independently, selected from the group consisting of C1-Clo alkyl; benzyl, aryl and substituted benzyl or aryl.

(iii) n is an integer from 0 to 3; and (iv) Bn is a benzyl group.

This intermediate product is then subjected to a subsequent hydrogenolysis reaction in order to cleave said benzyl protective group from the intermediate product above to provide the final desired product. Selective removal of hydroxyl protecting groups including O-benzyl groups is known.

Bieg and Szeja, Removal of O-Benzyl Protective Groups by Catalytic Transfer Hydrogenation, Synthesis, January 1985, discloses the cleavage of benzyl ethers of monosaccharides using ammonium formate as a hydrogen donor and palladium on carbon catalyst. It is further disclosed therein that said method may be used for the selective removal of O-benzyl ethers in the presence of other types of O-protecting groups. Bieg and Szeja, Cleavage of 2- Phenyl-1.3-dioxolanes and Benzyl Ethers by Catalytic Transfer Hydrogenation, Synthesis, April 1986, discloses cleavage of 2-phenyl-1,3-dioxolane protective groups by catalytic transfer hydrogenation which circumvents the disadvantage of simultaneous cleavage of a 2-phenyl-1,3-dioxane group also present in the molecule. Hydrazine hydrate is used as the hydrogen source and palladium on carbon as the catalyst. Said reaction may be utilized for preparation of a whole range of partially protected sugars.

In the present invention the hydrogenolysis step is as illustrated below:

[H]

Catalyst

[H]

Catalyst OBn 0 OR'

RR

R

Cleavage of the benzyl group is accomplished in virtually quantitative yield with non-acidic hydrogen transfer sources such as hydrazine hydrate and ammonium formate in combination with a supported metal catalyst. The acetal portion of the intermediate molecule is unaffected by these conditions, eliminating the simultaneous formation of hydroquinone and/or regeneration of monobenzone. Hence there is no need for any chromatographic separation and the desired compounds can be isolated via simple purification techniques.

Overall yield for the two step process is significantly higher than the previously disclosed one step process.

Reaction Method A. STEP ONE As disclosed above the first step of the process is to produce the protected intermediate. In the case of the benzyl protecting group, 4- (benzyloxy)phenol is combined with a cyclic or acyclic enol ether and a catalytic amount of acid under an inert atmosphere. In general, the stoichiometric ratio of enol ether and 4-(benzyloxy)phenol is from 1:1 to 2:1. A variety of acidic sources can be used, preferably those selected from the group consisting of hydrochloric acid, sulfuric acid, para-toluenesulfonic acid and mixtures thereof, wherein the catalytic dose does not exceed 0.02 equivalents based on the weight of 4-(benzyloxy)phenol. A typical dose is 0.005-0.015 equivalents of acid. Most preferred acidic source is hydrochloric acid.

Formation of the intermediate is conveniently carried out in a variety of polar organic solvents. Preferred polar solvents include those selected from the group consisting of methylene chloride, diethylether, tetrahydrofuran, dioxane and mixtures thereof, most preferred being methylene chloride. Typical total reactant concentrations are in the 5-15% weight range, although complete solvation of 4-(benzyloxy)phenol is not crucial.

Depending on the amount of starting materials, the intermediate forming reaction takes from about 1 to about 16 hours at room temperature and atmospheric pressure. Changing the order of addition of starting materials has no affect on intermediate formation. In general, the reaction can be accelerated and forced to completion via the addition of further quantities of enol ether. After solvent removal a series of washes and triturations with non-polar solvents, typically hexanes, allows purification of the intermediate in high yield, normally greater than about 80%. In the present invention a particular advantage of the use of 4-(benzyloxy)phenol is that large scale chromatographic purification is not required since any unreacted 4-(benzyloxy)phenol can be conveniently removed with an aqueous sodium hydroxide wash.

B. STEP TWO Following the formation of said intermediate in step one, step two of the present process involves selective hydrogenolysis of the O-benzyl protecting group. Said hydrogenolysis is accomplished by using any number of hydrogen donors. In the present invention it is preferred that the hydrogen transfer source is non-acidic and is selected from the group consisting of hydrazine, ammonium formate, trialkylammonium formates, and mixtures thereof; all readily available from commercial sources or which can be made prepared prior to reaction.

Hydrazine is typically supplied in the hydrate form (55% w/w hydrazine) which can be used without further purification. The molar ratio of hydrogen transfer source to intermediate is from about 6:1 to about 1:1, preferably 4:1 to about 2:1, and most preferably 3:1.

Said hydrogenolysis also requires a supported metal catalyst, preferably a carbon supported metal selected from the group consisting of palladium, platinum, nickel and mixtures thereof. Most preferred is palladium on carbon.

The weight percentage of metal in the supported catalyst is from about 2-20%, preferably 5-10%.

The reaction is carried out in an organic solvent which fully dissolves the intermediate upon refluxing. The preferred organic solvent is a hydroxy solvent, most preferred are those selected from the group consisting of methanol, ethanol, isopropanol and mixtures thereof, preferably methanol and ethanol.

Intermediate concentrations are typically in the 5-15% weight range relative to solvent.

Depending on the amount of starting materials, complete removal of benzyl group generally takes from about 0.5 to about 2.0 hours at reflux under an inert atmosphere. In the present invention a particular advantage of the use of non-acidic hydrogen transfer sources is that large scale chromatographic purification is not required since essentially no hydroquinone or monobenzone byproducts are formed. The product is dried by solvent/water stripping and trituration with non-polar solvents or recrystallization from water/alcohol mixtures.

With regard to this second step involving reaction of the intermediate with said hydrogen donor, it is preferred that said intermediate is substantially free from impurities since they can negatively affect the reaction by, for example, modifying the surface of the preferred metal catalysts used herein.

EXAMPLE I 4-[(Tetrahydrofuran-2-yl)oxy]phenol is prepared as follows:

OH

00T_ o HCI

N

2

H

4

.H

2 0

\CH

2

CI

2 5% Pd/C HEtO

H

OH

STEP ONE: Combine 4-(benzyloxy)phenol (34.0 g, 0.17 mol), concentrated hydrochloric acid (0.20 ml, 37%) and 300 ml of methylene chloride. Add to the resulting suspension drop by drop a solution of 2,3-dihydrofuran (22.8 g 0.33 mol) and 100 ml of methylene chloride. Stir the mixture at room temperature under an inert atmosphere for 16 hours at which time only trace amounts of 4- (benzyloxy)phenol remain by standard thin layer chromatography analysis (Vogel's Textbook of Practical Organic Chemistry, 5th Edition, p.199). Wash the reaction mixture with about three aliquots of 1 N sodium hydroxide, each 300 ml, and back extract said aqueous washes with about 200 ml of methylene chloride.

Combine the organic layers, dry over sodium sulfate, and concentrate in-vacuo to an oil. Crystallize 2-[(4-benzyloxy)phenoxy]tetrahydrofuran from said oil via careful trituration with a non-polar solvent such as hexanes; melting point 43- 44°C.

STEP TWO: Add 55% hydrazine hydrate (1.8 g, 30.0 mmol) to a solution comprising 2-[(4-benzyloxy)phenoxy]tetrahydrofuran (2.7 g, 10.0 mmol), 5% Pd/C (0.4 g of wet material) and 50 ml of absolute ethanol. Heat reaction mixture at reflux under an inert atmosphere for about 30 minutes. Cool the reaction mixture and filter off the catalyst. Concentrate the resulting clear pale yellow filtrate to an oil in-vacuo and co-distill in succession with two aliquots of ethanol (50 ml), two aliquots of ethyl acetate (50 ml) and two aliquots of hexanes (50 ml). Triturate the resulting solid with about 25 ml of hexane and dry in-vacuo at 40 0 C to constant weight. Composition and purity of the cream colored 4- [tetrahydrofuran-2-yl)oxy]phenol is confirmed by 1H and 13C NMR and elemental analysis; melting point 59-61 0

C.

EXAMPLE II 4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol is prepared as follows:

OH

SHCI N 2

H

4

.HO

+CH2C2 5% Pd/C O EtOH

OH

STEP ONE: Slowly add, under an inert atmosphere, a methylene chloride solution of 3,4-dihydro-2H-pyran (37.3 g, 0.44 mol) to a solution comprising 4- (benzyloxy)phenol (88.8 g, 0.44 mol), concentrated hydrochloric acid (0.25 ml, 37%) and 600 ml of methylene chloride. This reaction mixture is stirred at room temperature for about 15 minutes, at which time a substantial amount of 4- (benzyloxy)phenol is present by thin layer chromatography. Add to the reaction mixture two consecutive portions of a solution comprising 3,4-dihydro-2H-pyran (7.5 g) and 25 ml of methylene chloride. Stir the mixture for about 1 hour wherein only trace amounts of starting phenol remain.

Wash the reaction mixture with about three aliquots of 4% aqueous sodium hydroxide, each 400 ml. Separate the aqueous layer and back extract said layer with about 100 ml of methylene chloride. Combine the organic layers, dry over sodium sulfate, and concentrate in vacuo at about 40 0 C to a volume of about 200 ml. Remove excess methylene chloride by co-distilling said concentrate with a sufficient amount of hexane to bring the total volume of the distillate to about 250 ml. Dilute the resulting white suspension with hexane and cool said mixture to about ambient temperature. Collect the precipitated intermediate, 2-[(4-benzyloxy)phenoxy]tetrahydropyran, on a filter and wash insitu with 100 ml aliquots of hexane. Dry said precipitate in vacuo at about 35 0

C

until a constant weight is obtained; melting point 70-71 0

C.

STEP TWO: Add 55% hydrazine hydrate (34.85 g, 0.6 mol) to a stirred suspension comprising 2-[(4-benzyloxy)phenoxy]tetrahydropyran (56.4 g, 0.2 mol), 5% Pd/C (4.1 g of 50% wet material) and about 450 ml of absolute ethanol. Slowly heat the reaction mixture and maintain at reflux under an inert atmosphere until thin layer chromatography analysis indicates complete consumption of benzyloxy)phenoxy]tetrahydropyran. Cool the reaction mixture to about 50 0

C,

clarify said mixture by filtration, and concentrate to a solid in-vacuo at 40 0

C.

Suspend said solid in ethanol and slowly dilute said suspension with deionized water. Stir for about 30 minutes and collect the white solid on a filter.

Wash said solid in-situ with water, then re-suspend the solid in water. Re-collect the solid, wash in-situ with water and dry in-vacuo at 24 0 C to constant weight.

Further purification of 4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol, if necessary, is achieved by a second round of recrystallization from aqueous ethanol. Composition and purity is confirmed by 1H and 13C NMR and elemental analysis; melting point 86-87 0

C

EXAMPLE III 4-[(1-butoxyethyl)oxy]phenol is prepared as follows: 0

H

HC1

N

2

H

4

.H

2 0 CHC12 5% Pd/C O C I MeOH H STEP ONE: In similar fashion to Examples I and II, slowly add a methylene chloride solution of butyl vinyl ether (6.2 g, 0.06 mol) to a solution comprising- (benzyloxy)phenol (12.4 g, 0.06 mol), concentrated hydrochloric acid (0.15 ml, 37%) and 100 ml of methylene chloride. Stir under an inert atmosphere for about 2 hours and analyze reaction mixture for 4-(benzyloxy)phenol by thin layer chromatography. If 4-(benzyloxy)phenol is still present, add to said reaction mixture a further portion of butyl vinyl ether (1.8 g, 0.02 mol) in 25 ml of methylene chloride and continue to stir until the phenol is consumed.

Wash the reaction mixture with about three aliquots of 1N sodium hydroxide, each 250 ml, and back extract said aqueous washes with about 100 ml of methylene chloride. Combine the organic layers, dry over sodium sulfate, and concentrate benzyl protected intermediate in-vacuo to a pale yellow oil.

Composition and purity of intermediate is confirmed by 1H and 13C NMR.

STEP TWO: Add 55% hydrazine hydrate (2.5 g, 0.078 mol) to a stirred suspension comprising intermediate from step one (5.0 g, 0.017 mol), 5% Pd/C (3.8 g) and about 100 ml of methanol. Heat the reaction mixture and maintain at reflux under an inert atmosphere for about 2 hours whereupon thin layer chromatography analysis indicates complete consumption of the benzyl protected intermediate. Cool the reaction mixture to room temperature and filter off the catalyst. Concentrate the resulting clear pale yellow filtrate to an oil invacuo, wash with hexanes and dry to constant weight in-vacuo at 50 0

C.

Composition and purity of isolated -butoxyethyl)oxy]phenol is confirmed by 1H and 13C NMR.

The term "comprise" and its grammatical variations such as "comprising" when used in the description and claims is taken to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.

0

S.

0O 0 *000

S

0000 0S S

S

S

S

z~i ~T2:

Claims (13)

1. A process for preparing monoacetals of hydroquinone comprising the steps of: a) reacting monoether of hydroquinone with a cyclic or acyclic enol ether in the presence of an acid catalyst to yield the protected monoacetal of hydroquinone as an intermediate; and b) reacting said intermediate with a hydrogen transfer source in the presence of a metal catalyst such that protecting group is selectively cleaved to give the desired hydroquinone monoacetal.

2. The process according to claim 1 wherein the hydrogen transfer source is non-acidic.

3. The process according to claim 1 or 2 wherein the ether protecting group is selected from the group consisting of arylmethyl, diarylmethyl, triarylmethyl, trimethylsilyl ethers and mixtures thereof. S 4. The process according to claim 3 wherein the ether protecting group is an arylmethyl ether selected from the group consisting of benzyl, aliphatic benzyl ethers and mixtures thereof. The process according to claim 4 wherein the ether protecting group is selected from the group consisting of aliphatic benzyl ethers and mixtures thereof.

6. The process according to claim 5 wherein the ether protecting group is monobenzyl ether. o* S

7. The process according to any one of claims 1 to 6 wherein the hydrogen transfer source is non-acidic and selected from the group consisting of hydrazine, ammonium formate, trialkylammonium formates, and mixtures thereof, in a molar ratio of hydrogen transfer source to 0 intermediate product from 6:1 to 1:1. 0

8. The process according to claim 7 wherein the hydrogen transfer source is hydrazine in a molar ratio of hydrazine to intermediate product of 4:1 to 2:1. 7- V T ^ta >N' 14

9. The process according to any one of claims 1 to 8 wherein the formation of the intermediate is carried out in a polar organic solvent selected from the group consisting of methylene chloride, diethylether, tetrahydrofuran, dioxane and mixtures thereof The process according to claim 9 wherein the formation of the intermediate product is carried out in methylene chloride.

11. The process according to any one of claims 1 to 10 wherein the metal catalyst is a carbon supported metal selected from the group consisting of palladium, platinum, nickel and mixtures thereof, wherein the weight percentage of metal in the supported catalyst is from 2-20%.

12. The process according to claim 11 wherein the metal catalyst is palladium on carbon.

13. The process according to claim 9 or 10 wherein the reaction of the intermediate and hydrogen transfer source is carried out in a polar organic solvent.

14. The process according to claim 13 wherein the reaction of the intermediate and hydrogen transfer source is carried out in a hydroxy solvent selected from the group consisting of methanol, ethanol, isopropanol and mixtures thereof. The process according to claim 14 wherein the reaction of the intermediate and hydrogen transfer of source is carried out in a hydroxy solvent is selected from the group consisting of methanol, ethanol and mixtures thereof.

16. The process according to claim 1 substantially as hereinbefore described with reference to the examples. G

17. A process for preparing monoacetals of hydroquinone comprising the steps of: a) reacting monoether of hydroquinone with an enol ether in the presence of an acid Scatalyst to yield an intermediate monoacetal of hydroquinone that is protected by an ether protecting group; and 4 4 b) reacting said intermediate with a non-acidic hydrogen transfer source selected from the group consisting of hydrazine, ammonium formate, trialkylammonium formates, and mixtures thereof, in a molar ratio of hydrogen transfer source to intermediate from 6:1 to 1:1, in the presence of a metal catalyst such that the ether protecting group is selectively cleaved to give the desired hydroquinone monoacetal. DATED this 26th day of November, 1999 THE PROCTER GAMBLE COMPANY WATERMARK PATENT TRADEMARK ATTORNEYS 290 BURWOOD ROAD HAWTHORN VICTORIA 3122 AUSTRALIA S, LCG:JGC:MEH P2840AU01.DOC *0* 0 0 0 *5 K: