AU7109096A - Cryptophycins from aberrant biosynthesis - Google Patents

Cryptophycins from aberrant biosynthesis

Info

Publication number
AU7109096A
AU7109096A AU71090/96A AU7109096A AU7109096A AU 7109096 A AU7109096 A AU 7109096A AU 71090/96 A AU71090/96 A AU 71090/96A AU 7109096 A AU7109096 A AU 7109096A AU 7109096 A AU7109096 A AU 7109096A
Authority
AU
Australia
Prior art keywords
cryptophycins
aberrant
biosynthesis
aberrant biosynthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU71090/96A
Other versions
AU709828B2 (en
Inventor
Thomas K. Hemscheidt
Richard E Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Original Assignee
University of Hawaii
Wayne State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hawaii, Wayne State University filed Critical University of Hawaii
Publication of AU7109096A publication Critical patent/AU7109096A/en
Assigned to UNIVERSITY OF HAWAII reassignment UNIVERSITY OF HAWAII Amend patent request/document other than specification (104) Assignors: UNIVERSITY OF HAWAII, WAYNE STATE UNIVERSITY
Application granted granted Critical
Publication of AU709828B2 publication Critical patent/AU709828B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
AU71090/96A 1995-08-30 1996-08-30 Cryptophycins from aberrant biosynthesis Ceased AU709828B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US293595P 1995-08-30 1995-08-30
US60/002935 1995-08-30
PCT/US1996/014670 WO1997008334A1 (en) 1995-08-30 1996-08-30 Cryptophycins from aberrant biosynthesis

Publications (2)

Publication Number Publication Date
AU7109096A true AU7109096A (en) 1997-03-19
AU709828B2 AU709828B2 (en) 1999-09-09

Family

ID=21703268

Family Applications (2)

Application Number Title Priority Date Filing Date
AU69048/96A Abandoned AU6904896A (en) 1995-08-30 1996-08-30 Pharmaceutical compounds
AU71090/96A Ceased AU709828B2 (en) 1995-08-30 1996-08-30 Cryptophycins from aberrant biosynthesis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU69048/96A Abandoned AU6904896A (en) 1995-08-30 1996-08-30 Pharmaceutical compounds

Country Status (6)

Country Link
EP (2) EP0850316A4 (en)
JP (2) JP2000507805A (en)
AU (2) AU6904896A (en)
BR (1) BR9610214A (en)
CA (2) CA2230540A1 (en)
WO (2) WO1997007798A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007798A1 (en) * 1995-08-30 1997-03-06 Eli Lilly And Company Pharmaceutical compounds
JP2000502351A (en) * 1995-12-22 2000-02-29 イーライ・リリー・アンド・カンパニー Pharmaceutical compounds
ES2267149T3 (en) * 1996-08-30 2007-03-01 University Of Hawaii NEW CRYPTOPHINE DERIVATIVES AS ANTINEOPLASIC AGENTS.
JP2001500484A (en) * 1996-08-30 2001-01-16 イーライ・リリー・アンド・カンパニー Method for producing pharmaceutical compounds
AU4330097A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Pharmaceutical compounds
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
IL128643A0 (en) * 1996-09-06 2000-01-31 Lilly Co Eli Process to prepare pharmaceutical compounds
US6020512A (en) * 1996-09-06 2000-02-01 Eli Lilly And Company Process and novel intermediates
NZ336918A (en) * 1997-02-26 2001-11-30 Lilly Co Eli Selective epoxidation process for preparing pharmaceutical compounds comprising Cryptophycin 52
WO1998038178A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Tripeptide and tetrapeptide pharmaceutical compounds
EP0870506A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
EP0870501A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections
US6180679B1 (en) * 1998-04-07 2001-01-30 Eli Lilly And Company Method for treating fungal infections
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2003077906A1 (en) * 2002-03-18 2003-09-25 Nihon University Cyclic etheramine derivatives as medicaments for malignant tumors
US7229814B2 (en) 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
JPWO2007000994A1 (en) * 2005-06-28 2009-01-22 中外製薬株式会社 Method for producing compound having anti-HCV action
CN103724290B (en) * 2013-11-15 2015-04-29 浙江大学 Cyclopeptide compound clavatustide A as well as producing strain, preparation method and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
PL185949B1 (en) * 1995-03-07 2003-09-30 Univ Hawaii Novel synthetic cryptophycines
WO1997007798A1 (en) * 1995-08-30 1997-03-06 Eli Lilly And Company Pharmaceutical compounds

Also Published As

Publication number Publication date
EP0850057A1 (en) 1998-07-01
JP2000501067A (en) 2000-02-02
BR9610214A (en) 1999-06-15
WO1997007798A1 (en) 1997-03-06
AU709828B2 (en) 1999-09-09
EP0850316A4 (en) 2000-08-23
CA2246117A1 (en) 1997-03-06
WO1997008334A1 (en) 1997-03-06
CA2230540A1 (en) 1997-03-06
AU6904896A (en) 1997-03-19
EP0850316A1 (en) 1998-07-01
JP2000507805A (en) 2000-06-27
EP0850057A4 (en) 2001-04-11

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired