AU710337B2 - Alpha 1a adrenergic receptor antagonists - Google Patents

Alpha 1a adrenergic receptor antagonists Download PDF

Info

Publication number
AU710337B2
AU710337B2 AU77343/96A AU7734396A AU710337B2 AU 710337 B2 AU710337 B2 AU 710337B2 AU 77343/96 A AU77343/96 A AU 77343/96A AU 7734396 A AU7734396 A AU 7734396A AU 710337 B2 AU710337 B2 AU 710337B2
Authority
AU
Australia
Prior art keywords
compound
hydrogen
cyano
alkyl
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU77343/96A
Other languages
English (en)
Other versions
AU7734396A (en
Inventor
Mark G. Bock
Michael A. Patane
Rose Ann Ponticello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603423.6A external-priority patent/GB9603423D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7734396A publication Critical patent/AU7734396A/en
Application granted granted Critical
Publication of AU710337B2 publication Critical patent/AU710337B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU77343/96A 1995-11-15 1996-11-12 Alpha 1a adrenergic receptor antagonists Ceased AU710337B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US676595P 1995-11-15 1995-11-15
US60/006765 1995-11-15
GBGB9603423.6A GB9603423D0 (en) 1996-02-19 1996-02-19 Alpha la adrenergic receptor antagonists
GB9603423 1996-02-19
PCT/US1996/018321 WO1997017967A1 (en) 1995-11-15 1996-11-12 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
AU7734396A AU7734396A (en) 1997-06-05
AU710337B2 true AU710337B2 (en) 1999-09-16

Family

ID=26308752

Family Applications (1)

Application Number Title Priority Date Filing Date
AU77343/96A Ceased AU710337B2 (en) 1995-11-15 1996-11-12 Alpha 1a adrenergic receptor antagonists

Country Status (4)

Country Link
EP (1) EP0865280A1 (ja)
JP (1) JPH11507395A (ja)
AU (1) AU710337B2 (ja)
WO (1) WO1997017967A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109956909A (zh) * 2019-04-24 2019-07-02 上海卡洛化学有限公司 一种2-氰基哌嗪-1-羧酸叔丁酯的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212176A (en) * 1990-06-29 1993-05-18 Abbott Laboratories R(+)-terazosin
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
US5580871A (en) * 1992-11-20 1996-12-03 The Dupont Merck Pharmaceutical Company 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582513B1 (fr) * 1985-05-28 1988-08-05 Synthelabo Compositions pharmaceutiques contenant de l'alfuzosine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212176A (en) * 1990-06-29 1993-05-18 Abbott Laboratories R(+)-terazosin
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
US5580871A (en) * 1992-11-20 1996-12-03 The Dupont Merck Pharmaceutical Company 4-Heteroaryl- 1,4-dihydropyridine compounds with calcium agonist and alpha1 -antagonist activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109956909A (zh) * 2019-04-24 2019-07-02 上海卡洛化学有限公司 一种2-氰基哌嗪-1-羧酸叔丁酯的制备方法

Also Published As

Publication number Publication date
WO1997017967A1 (en) 1997-05-22
JPH11507395A (ja) 1999-06-29
EP0865280A1 (en) 1998-09-23
AU7734396A (en) 1997-06-05

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired