AU6904596A - Method and construct for screening for inhibitors of transcriptional activation - Google Patents

Method and construct for screening for inhibitors of transcriptional activation

Info

Publication number
AU6904596A
AU6904596A AU69045/96A AU6904596A AU6904596A AU 6904596 A AU6904596 A AU 6904596A AU 69045/96 A AU69045/96 A AU 69045/96A AU 6904596 A AU6904596 A AU 6904596A AU 6904596 A AU6904596 A AU 6904596A
Authority
AU
Australia
Prior art keywords
inhibitors
screening
construct
transcriptional activation
transcriptional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU69045/96A
Inventor
Jaime Escobedo
Klaus Giese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of AU6904596A publication Critical patent/AU6904596A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
AU69045/96A 1995-09-13 1996-08-21 Method and construct for screening for inhibitors of transcriptional activation Abandoned AU6904596A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US370895P 1995-09-13 1995-09-13
US003708 1995-09-13
US68992696A 1996-08-15 1996-08-15
US689926 1996-08-16
PCT/US1996/013845 WO1997010360A1 (en) 1995-09-13 1996-08-21 Method and construct for screening for inhibitors of transcriptional activation

Publications (1)

Publication Number Publication Date
AU6904596A true AU6904596A (en) 1997-04-01

Family

ID=26672088

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69045/96A Abandoned AU6904596A (en) 1995-09-13 1996-08-21 Method and construct for screening for inhibitors of transcriptional activation

Country Status (3)

Country Link
EP (1) EP0850318A1 (en)
AU (1) AU6904596A (en)
WO (1) WO1997010360A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9710882D0 (en) * 1997-05-27 1997-07-23 Medical Res Council Trapping promoters
EP1032707A2 (en) * 1997-11-21 2000-09-06 Yale University Method for identifying and inhibiting functional nucleic acid molecules in cells
US6013447A (en) * 1997-11-21 2000-01-11 Innovir Laboratories, Inc. Random intracellular method for obtaining optimally active nucleic acid molecules
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
ES2374290T3 (en) 1998-03-20 2012-02-15 Commonwealth Scientific And Industrial Research Organisation SYNTHETIC GENES AND GENETIC CONSTRUCTS THAT INCLUDE THE SAME.
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6248525B1 (en) 1998-03-30 2001-06-19 Yale University Method for identifying essential or functional genes
GB9818319D0 (en) * 1998-08-21 1998-10-14 Agrevo Uk Ltd Fungicidal test method
WO2000044914A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1283267A4 (en) * 2000-05-15 2004-05-12 Tokyo Metropolitan Org Med Res Vector for analysing replication mechanism of rna virus and use thereof
KR20020035393A (en) * 2000-11-06 2002-05-11 신호진 Reporter Vectors for Evaluating the Activity of Transcription Factors or Promoters and Cell Lines Transformed with the same
CA2369944A1 (en) 2001-01-31 2002-07-31 Nucleonics Inc. Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017488A (en) * 1986-04-01 1991-05-21 University Of Medicine And Dentistry Of New Jersey Highly efficient dual T7/T3 promoter vector PJKF16 and dual SP6/T3 promoter vector PJFK15
IL97048A0 (en) * 1991-01-25 1992-03-29 R O B I T Research And Dev Com Bioluminescence assay for gene expression in growing mammalian cells
DE4103289A1 (en) * 1991-02-04 1992-08-06 Battelle Institut E V Determn. of lactose repressor over-producing microorganisms - using a phage with a marker gene contg. C-terminal with a lactose operator and promoter which forms an anti-sense RNA of the marker
US5654398A (en) * 1993-06-03 1997-08-05 The Regents Of The University Of California Compositions and methods for inhibiting replication of human immunodeficiency virus-1
WO1995020652A1 (en) * 1994-01-28 1995-08-03 Medigene Gmbh Method of determining the activity of a regulatory factor, and use of the method

Also Published As

Publication number Publication date
EP0850318A1 (en) 1998-07-01
WO1997010360A1 (en) 1997-03-20

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