AU6853390A - Diaza compounds - Google Patents

Diaza compounds

Info

Publication number
AU6853390A
AU6853390A AU68533/90A AU6853390A AU6853390A AU 6853390 A AU6853390 A AU 6853390A AU 68533/90 A AU68533/90 A AU 68533/90A AU 6853390 A AU6853390 A AU 6853390A AU 6853390 A AU6853390 A AU 6853390A
Authority
AU
Australia
Prior art keywords
diaza compounds
diaza
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU68533/90A
Other versions
AU646006B2 (en
Inventor
Peter Buhlmayer
Peter Herold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU6853390A publication Critical patent/AU6853390A/en
Application granted granted Critical
Publication of AU646006B2 publication Critical patent/AU646006B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
AU68533/90A 1989-12-28 1990-12-27 Diaza compounds Ceased AU646006B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4663/89 1989-12-28
CH466389 1989-12-28

Publications (2)

Publication Number Publication Date
AU6853390A true AU6853390A (en) 1991-07-04
AU646006B2 AU646006B2 (en) 1994-02-03

Family

ID=4280298

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68533/90A Ceased AU646006B2 (en) 1989-12-28 1990-12-27 Diaza compounds

Country Status (14)

Country Link
EP (1) EP0435827A3 (en)
JP (1) JPH06199811A (en)
KR (1) KR910011802A (en)
AU (1) AU646006B2 (en)
CA (1) CA2033121A1 (en)
FI (1) FI906387A (en)
HU (1) HU207513B (en)
IE (1) IE904686A1 (en)
IL (1) IL96753A0 (en)
MX (1) MX23949A (en)
NO (1) NO905602L (en)
NZ (1) NZ236625A (en)
PT (1) PT96371A (en)
ZA (1) ZA9010395B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650319B2 (en) * 1991-02-20 1994-06-16 Synthelabo 4-pyrimidinone derivatives, their preparation and their application in therapy

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324729A (en) * 1990-03-30 1994-06-28 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
CA2079344A1 (en) * 1990-03-30 1991-10-01 Eric E. Allen Substituted pyrimidines, pyrimidinones and pyridopyrimidines
US5250548A (en) * 1990-09-10 1993-10-05 Abbott Laboratories Angiotensin II receptor antagonists
CA2053148A1 (en) * 1990-10-16 1992-04-17 Karnail Atwal Dihydropyrimidine derivatives
FR2676734B1 (en) * 1991-05-23 1995-05-19 Roussel Uclaf NEW PYRIMIDINE DERIVATIVES, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IL101860A0 (en) * 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
FR2678618B1 (en) * 1991-07-05 1993-11-05 Upsa Laboratoires NOVEL TRIAZOLO PYRIMIDINE DERIVATIVES ANTIAGONISTS OF ANGIOTENSIN II RECEPTORS; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5358950A (en) * 1991-07-05 1994-10-25 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1250749B (en) * 1991-08-02 1995-04-21 Luso Farmaco Inst HETEROCYCLIC COMPOUNDS ACTIVATED IN II ANTAGONIST
US5336677A (en) * 1991-10-24 1994-08-09 American Home Products Corporation Substituted aminopyrimidines as antihypertensives
DE4221583A1 (en) * 1991-11-12 1993-05-13 Bayer Ag SUBSTITUTED BIPHENYLPYRIDONE
TW284688B (en) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
US5378704A (en) * 1992-04-15 1995-01-03 E. R. Squibb & Sons, Inc. Non-peptidic angiotensin-II-receptor-antagonists
US5236916A (en) * 1992-05-26 1993-08-17 E. R. Squibb & Sons, Inc. Oxadiazinone substituted indole and benzimidazole derivatives
IT1263804B (en) * 1993-01-22 1996-09-03 Luso Farmaco Inst PYRIMIDINONIC DERIVATIVES MELT WITH NITROGEN HETEROCYCLES ACTIVATED IN II ANTAGONIST
DE4314963A1 (en) * 1993-05-06 1994-11-10 Bayer Ag Substituted pyridines and 2-oxo-1,2-dihydropyridines
SE9903028D0 (en) 1999-08-27 1999-08-27 Astra Ab New use
MX2009013293A (en) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2155643B1 (en) 2007-06-08 2016-08-10 MannKind Corporation Ire-1a inhibitors
ES2627848T3 (en) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (en) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
EP2420501A4 (en) 2009-04-17 2012-08-29 Kowa Co Novel compound having 3-heteroarylpyrimidin-4-(3h)-one structure and pharmaceutical preparation containing same
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514671A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists and uses thereof
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102272746B1 (en) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 Ultra-pure agonists of guanylate cyclase c, method of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650319B2 (en) * 1991-02-20 1994-06-16 Synthelabo 4-pyrimidinone derivatives, their preparation and their application in therapy

Also Published As

Publication number Publication date
AU646006B2 (en) 1994-02-03
FI906387A (en) 1991-06-29
KR910011802A (en) 1991-08-07
JPH06199811A (en) 1994-07-19
NO905602L (en) 1991-07-01
CA2033121A1 (en) 1991-06-29
HU207513B (en) 1993-04-28
NO905602D0 (en) 1990-12-27
ZA9010395B (en) 1991-08-28
MX23949A (en) 1994-03-31
EP0435827A3 (en) 1991-11-13
IE904686A1 (en) 1991-07-17
FI906387A0 (en) 1990-12-21
IL96753A0 (en) 1991-09-16
EP0435827A2 (en) 1991-07-03
PT96371A (en) 1991-10-15
NZ236625A (en) 1993-02-25
HUT56091A (en) 1991-07-29

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