AU668670B2

AU668670B2 - Cosmetic or pharmaceutical composition and use thereof

Info

Publication number: AU668670B2
Application number: AU20438/95A
Authority: AU
Inventors: Lucien Aubert; Jean-Claude Contamin; Jean De Rigal; Jean-Luc Leveque
Original assignee: LOreal SA
Current assignee: LOreal SA
Priority date: 1994-06-16
Filing date: 1995-06-01
Publication date: 1996-05-09
Anticipated expiration: 2015-06-01
Also published as: KR960000208A; ATE147259T1; US5618521A; DE69500129T2; DE69500129D1; FR2721208B1; EP0692247B1; AU2043895A; JPH083015A; CA2151888A1; BR9502224A; CA2151888C; EP0692247A1; ES2099643T3; JP2662204B2; FR2721208A1; KR0168706B1

Abstract

Compsns. for topical use comprise a cosmetically acceptable carrier, an antioxidant (I) and an extract (II) of non-photosynthetic and non-fruiting filamentous bacteria.

Description

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Patents Act 1990 COMPLETE SPECIFICATION STANDARD PATENT Applicanat: L'I OREAL 0 0 0 00 0) 0 0 0 00 0 SO 00 0 0 0, 0000 0 0000 000 00 Invention Title: COSMETIC OR PHARM~ACEUTICAL COMPOSITION AND USE THEREOF The following statement is a full description of this invention, including the best method of performing it known to me/us: j The present invention relates to a cosmetic or pharmaceutical composition to be applied to the skin and/or the hair before, during and/or after exposure to UV radiation, the said composition being capable of preventing and/or attenuating the damage caused by the said radiation.

It is known that light rays with wavelengths between 320 nm and 400 nm (UV-A) permit tanning of the human epidermis; they are, however, liable to cause damage to the latter, especially in the case of sensitive skin or skin which is continuously exposed.

UV-A rays cause in particular a loss of elasticity of the skin and the appearance of wrinkles, leading to premature ageing. It is also known that light rays with wavelengths between 280 and 320 nm (UV-B) cause 00 erythema and skin burns which may be harmful to the *«natural development of a tan.

0 0It is thus necessary, in order to maintain suitable skin quality after exposure to UV radiation, 20 to prepare the skin before the exposure, to protect it during the exposure and possibly to attenuate the 0 damage caused by the exposure.

The aim of the present invention is to propose a composition to be applied to the skin and/or the hair, before, during and/or after exposure to UV radiation and which is capable of preventing and/or attenuating the damage caused by the said radiation.

One subject of the present invention is thus r ~i I r s a composition for topical use, in particular for the photoprotection of the skin and/or the hair, comprising, in a cosmetically acceptable support, an active substance consisting of the combination of at least one antioxidant and at least one extract of nonphotosynthetic and non-fruiting filamentous bacteria.

In the rest of the present description, the percentages are given by weight unless stated otherwise.

The characteristic feature of the compositions according to the invention is that they comprise, as active substance, an association consisting of at least one antioxidant and at least one extract of non-photosynthetic and non-fruiting filamentous bacteria.

0:It has, in fact, been observed that the combination of these two very specific constituents °o0° makes it possible to obtain an enhanced effect within the context of the photoprotection of the skin and/or o 20 the hair.

o4. The term extract of non-photosynthetic and non-fruiting filamentous bacteria refers both to the 0 actual extracts and to the biomass obtained after culturing the said bacteria, the said biomass possibly being partially dehydrated and/or ground.

The bacterial extracts according to the invention are prepared from non-photosynthetic and non-fruiting filamentous bacteria as defined according to the classification of Bergey's Manual of Systematic Bacteriology (vol. 3, section 23, 9th edition, 1989), among which there may be mentioned the bacteria belonging to the order of Beggiatoales, and more particularly the bacteria belonging to the genera Beggiatoa, Vitreoscilla, Flexithrix or Leucothrix.

Among the bacteria belonging to the genus Beggiatoa, the bacteria of the strains of Beggiatoa alba (ATCC 33555) may preferably be employed.

In order to prepare the extract according to the invention, the said bacteria may be cultured according to the methods known to those skilled in the art, and subsequently separated from the biomass obtained, for example by filtration, centrifugation and/or freeze-drying.

0. The extract may be used in the form of derivatives, for example in the form of at least partially acylated derivatives. The acylation may then be carried out using arganic carboxylic anhydride, such o. 20 as acetic anhydride, or using the corresponding acid S' chloride such as acetyl chloride. The acylation is S. carried out such that at least some of the primary and secondary amine groups present in the bacterial biomass are in acylated form.

In the compositions according to the invention, 0.01 to 2% solids content of bacterial extract may be used relative to the total weight of the composition.

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The bacterial extract may be incorporated in dispersion form in a suitable vehicle such as water, organic solvents and fatty substances including oils, alone or as a mixture.

The cosmetic composition according to the invention also comprises an antioxidant. The term antioxidant refers to any compound capable of having an action against oxygenated free radicals and/or a peroxide-inactivating action, The said antioxidant is present in the composition at an amount of from 0.001 to 30% by weight, the said amount depending on the nature of the said antioxidant.

Thus, it is possible, for example, to use an antioxidant chosen from tocopherol and derivatives thereof, acetate, linoleate or nicotinate inter alia, preferably at concentrations of the order of 0.1 to *y-orizanol (0.1 to 20 lysine pidolate or arginine pidolate (0.5 to *plant extracts such as extract of balm (0.01 to extract of silimarin (0.01 to extract of gingko (0.05 to extract of sage (0.05 to extract of cola nuts (0.05 to extract of rutin (0.1 to or extract of thyme (0.1 to the symbol being given as solids content, *proanthocyanolidine oligomers of pine, of hawthorn or of grape (0.1 to 400 0 B 0? 0 o 0000* o o o a 0000 00 6 o a o tO 0 ¢JVu a o~~ a i ii *di-tert-butylhydroxybenzylidenecamphor (0.1 to *green tea (0.1 to *caffeine (0.1 to *glycerol (2 to mannitol (2 to *carnosine (0.1 to *superoxide dismutase (100 to 10,000 IU/100 g), *guanosine (0.01 to Smicroalgae containing ethoxyquine, such as Hematococcus (0.005 to pentasodium aminotrimethylenephosphonate (0.001 to *lactoperoxidase (0.01 to and *lactoferrin (0.01 to A mixture of several antioxidants may also be used.

o 0 0 The compositions according to the invention may be in all the forms which may be envisaged in the cosmetic or pharmaceutical field, in particular in the o:o 20 form of a care product, an antisun product, an after- S0 sun product, a hair product or a make-up product.

The compositions according to the invention 0 a 0 may thus additionally comprise at least one conventional photoprotective system capable of S 25 screening UV (UV-A and/or UV-B) rays and which may thus consist of one or more organic sunscreens (UV absorbing agents) and/or of one or more inorganic (nano)pigments based on metal oxides, and in particular on titanium 4 j I "P 1. i I I- i 1: I 1 C q~ ~I oxide, which act by physically blocking the radiation (UV reflectors and/or diffusers).

The conventioril organic sunscreens may be chosen, alone or as mixtures, from 2-phenylbenzimidazole-5-sulphonic acid and salts thereof, cinnamic derivatives such as 2-ethylhexyl p-methoxycinnamate for example, salicylic derivatives such as 2-ethylhexyl-salicylate and homomenthyl salicylate for example, camphor derivatives such as, for example, 3-(4-methylbenzylidene)camphor or (1,4-divinylbenzene)camphorsulphonic acid and derivatives thereof (FR 2,528,420), triazine derivatives such as 2,4,6-tris[p-(2'-ethylhexyl- 1'-oxycarbonyl)anilino]-1,3,5-triazine, benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone, dibenzoylmethane derivatives such as 4-tert-butylo 4 oo0 4'-methoxydibenzoylmethane, p,p-diphenylacrylate 04.. derivatives such as 2-ethylhexyl a-cyano-p,pdiphenylacrylate, p-aminobenzoic acid derivatives such as octyl para-dimethylaminobenzoate for example, menthyl anthranilate, and the screening polymers and 0o. 4screening silicones described in Application WO-93-04665. Other examples of organic screening agents are given in Patent Application EP-A-0,487,404.

o40000 0 a The organic screening agent or agents are generally present in the compositions according to the invention at a concentration between 0.1 and 30% by weight, and preferably between 0.5 and 25% by weight, L Il I Im I I I I II Ill I I I 7 relative to the total weight of the composition.

The metal oxides constituting pigments or nanopigments which may be used within the context of the compositions in accordance with the present invention may be all those that are already known per se for their photoprotective activity. Thus, they may be chosen in particular, alone or as mixtures, from titanium oxide, zinc oxide, iron oxide, zirconium oxide, cerium oxide or mixtures thereof.

Metal oxide nanopigments are preferably used.

Such metal oxide nanopigments, which may or may not be coated, are products known to those skilled in the art and are described in particular in Patent Application EP-A-0,518,773, the teaching of which, in this regard, is included in the present description by S. way of reference. As additional commercial nanopigments 0 o. o not cited in the abovementioned Application but which may also be used within the context of the present invention, there may also be mentioned the products 20 sold under the trade names UVT M 160, UVT M 212 and UVT M 262 by the company Kemira, and MT 100 SA or MT 100 SAS by the company Tayca.

The average size of the primary particles of the nanopigments which may be present in the compositions according to the invention is generally between 5 nm and 100 nm, preferably between 10 and nm.

11 The nanopigments are generally present in the _i i~ 8 compositions according to the invention at a concentration between 0.1 and 30% by weight, and preferably between 1 and 20% by weight, relative to the total weight of the composition.

The overall content of the (organic screening agent(s) (nano)pigment(s)) screening system does not preferably exceed 40% of the total weight of the final antisun composition.

More particularly, the composition according to the invention may additionally comprise a sunscreen such as, for example, those described in Patent FR 2,528,420 and preferably the triethanolamine salt of terephthalylidene dicamphorsulphonic acid or MEXORYL SX®.

The compositions according to the invention may be in the form of a simple or complex W/O, O/W/O or W/O/W) emulsion such as a cream, a milk, a S. gel, an ointment or a cream gel, in the form of a powder or a solid stick or alternatively in the form of oo 20 a liquid, optionally packaged as an aerosol and being oa a I f l in the form of a foam or a spray. They may also be in o the form of a suspension or a dispersion in solvents or fatty substances, in the form of a nonionic vesicle dispersion, in the form of a shampoo, lotion or a hair fixing spray, or alternatively in anhydrous or aqueous, solid or pasty form.

The compositions of the invention may be I prepared acuording to the techniques that are well I I I I known to those skilled in the art.

The invention is illustrated in greater detail in the examples which follow.

Example 1 An antisun composition having the following composition is prepared: *stearic acid 3.

Scetyl alcohol 2.

*self-emulsifiable glyceryl monostearate 2.

petrolatum 2.

*sunflower oil 6.

.0% .0% .0% .0% .0% .0% *perhydrosqualene *octyl methoxycinnamate *triethanolamine salt of terephthalylidene 3.

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o c dicamphorsulphonic acid (MEXORYL SX) 2.6% *glycerol *preserving agents 0.3% Ssuperoxide dismutase 1200 IU/100 g *pentasodium aminotrimethylenephosphonate 0.1% 20 tocopherol *extract of Beggiatoa alba bacteria 0.05% *water qs 100% A composition which provides good protection for the skin against UV radiation is thus obtained.

Example 2 An after-sun composition having the following composition is prepared: cetostearyl alcohol 4,I i i -I i LL~ &UM1M1

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*cetyl alcohol *self-emulsifiable glyceryl monostearate *karite butter *rice bran oil avocado oil Sdioctyl palmitate *preserving agents *cyclomethicone *Carbomer 940 triethanolamine *tocopherol acetate *extract of Beggiatoa alba bacteria *water 0.3% 0.3% 0.3% 0.1% qs 100% a 0O 06 4 0 4 0 4 once 0 0 044t 00I 11114 a a t c tl 1 An after-sun composition capable of attenuating the damage caused by UV radiation is thus obtained.

Example 3 A care cream having the following composition is prepared: 20 stearic acid *cetyl alcohol Sself-emulsifiable glyceryl monostearate octyl methoxycinnamate glycerol preserving agents *superoxide dismutase *tocopherol *extract of Beggiatoa alba bacteria 0.3% 1000 IU/100 g 0.05% ,c I 1 9-1~9'1 i i 11 Carbomer 934 0.2% triethanolamine 0.2% water qs 100% A composition which provides good skin protection is thus obtained.

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Claims

1. Composition for topical use, in particular for the photoprotectioi of the skin and/or the hair, comprising, in a cosmetically acceptable support, an active substance consisting of the combination of at least one antioxidant and at least one extract of non-photosynthetic and non-fruiting filamentous bacteria.

2. Composition according to Claim 1, in which the said bacteria belong to the order of Beggiatoales.

3. Composition according to Claim 2, in which the said bacteria are chosen from bacteria belonging to the genera Beggiatoa, Vitreoscilla, o 15 Flexithrix or Leucothrix.

4. Composition according to Claim 3, in ooi4 o°o which the bacteria are chosen from the strains of oeot o Beggiatoa alba. o 2

5. Composition according to any one of the 20 preceding claims, in which the antioxidant is chosen, alone or as a mixture, from the group consisting of tocopherol and derivatives thereof; y-orizanol; lysine pidolate or arginine pidolate; extracts of balm, of 000000 silimarin, of gingko, of sage, of cola nuts, of rutin or of thyme; proanthocyanolidine oligomers of pine, of hawthorn or of grape; di-tert- butylhydroxybenzylidenecamphor; green tea; caffeine; glycerol; mannitol; carnosine; superoxide dismutase; i L lllllll ~lll ~la~lIr ii I_ I IC-_Cp- i II 13 guanosine; microalgae containing ethoxyquine; pentasodium aminotrimethylenephosphonate; lactoperoxidase and lactoferrin.

6. Composition according to any one of the preceding claims, in which the antioxidant is present at an amount of from 0.001 to 30% by weight relative to the weight of the composition.

7. Composition according to any one of the preceding claims, in which the bacterial extract is present at an amount of from 0.01 to 2% by weight relative to the weight of the composition.

8. Composition according to any one of the preceding claims to be applied to the skin and/or the hair before, during and/or after exposure to UV "o 15 radiation, in particular solar UV radiation. o

9. Composition according to any one of the o000 preceding claims, containing at least one conventional photoprotective system capable of screening UV (UV-A and/or UV-B) rays. 20

10. Composition according to Claim 9, containing a triethanolamine salt of terephthalylidene- dicamphorsulphonic acid.

11. Use of a combination of an antioxidant and at least one extract of non-photosynthetic and non- fruiting filamentous bacteria as active substance in a cosmetic or pharmaceutical composition intended for the photoprotection of the skin and/or the hair. DATED THIS 01ST DATE OF JUNE 1995 L'OREAL By its Patent Attorneys: GRIFFITH HACK CO. Fellows Institute of Patent Attorneys of Australia S( MWMWM- M k6 4-r C ABSTRACT Cosmetic or pharmaceutical composition and use thereof The present Application relates to a cosmetic or pharmaceutical composition which may be used to protect the skin and/or the hair from UV radiation, in particular solar UV radiation, by application before, during and/or after exposure. o 0 o o o o 0 0 i 0 o a C 4 0