AU614998B2

AU614998B2 - Sunscreen compositions

Info

Publication number: AU614998B2
Application number: AU23731/88A
Authority: AU
Inventors: Stephen Boothroyd; Edward Galley; Arija Margaret Stammers
Original assignee: Boots Co PLC
Current assignee: Boots Co PLC
Priority date: 1987-07-24
Filing date: 1988-10-12
Publication date: 1991-09-19
Anticipated expiration: 2008-10-12
Also published as: GB8817392D0; GB8717662D0; AU2373188A; DE3824999A1; GB2217987A; GB2217987B

Description

6 14 998 COMMONWEALTH OF AUSTRALIA PA'FT---J NAME ADDRESS OF APPLICANT: The Boots Company PLC 1 Thane Road West Nottingham United Kingdom NAME(S) OF ll{VENTOR(S): Stephen BOOTHROYD Edward GALLEY Ariija Margaret STAMMRS ADDRESS FOR SERVICE: ~unendi~.n nta m tj,~ u Lre (21 t yte Spr Vi~shg E Ij hr ori isaudo" fo~r 0~

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DAVIES COLLISON Patent Attorneys 1 Little Collins Street, Melbourne, 3000.

COMPLETE SPECIFICATION FOR THE ITNVENTION ENTITLED: Sunscren compositions The following statement is a full description of this invention, including the best method of perforing it known to me/us:-

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The present invention relates to sunscreen compositions. The term "sunscreen" is used herein to encompass tanning lotions, sunscreens and sunblockers which are intended for use on the body to provide protection against the sun's rays or other UV sources.

Heretofore sunscreen compositions have been prepared either as oil-in-water or water-in-oil emulsions containing organic sunscreen agents which could be formulated equally successfully in either of the above emulsion systems. More recently sunscreen compositions have been proposed which contain as the sunscreening agent, titanium dioxide. Titanium dioxide sunscreen formulations have heretofore been prepared as oil-in-water emulsions. The present invention stems from the applicants' discovery that titanium dioxide is more effective as a sunscreen when it is formulated as a water-in-oil emulsion.

The present invention provides a sunscreen composition which comprises a water-in-oil emulsion which comprises a) 0.5 to 30% by weight of titanium dioxide having a mean primary particle size of less o to 50 than l00nm, t by weight of an oil phase, c) 1 to 15% by weight of an emulsifier, and d) at least 25 by weight of an aqueous phase.

The titanium dioxide in the sunscreen compositions preferably has a mean primary particle size of between 1 and 100nm preferably between 5 and 50nm most preferably around 30nm. Titanium dioxide of the above mean primary particle size is usually referred to as "microfine". It is possible for the primary particles in microfine titanium dioxide to agglomerate in the compositions of the present invention but the 'Ii -02 ;I i; sunscreening activity remains that of the individual primary particles that make up the agglomerate. The titanium dioxide may have an anatase, rutile or amorphous structure. The particles are preferably uncoated but may be providad with a coating of an aluminium compound such as aluminium stearate to minimise light-induced reduction of the titanium dioxide and to aid dispersion of the particles in the water-in-oil emulsions of the present invention.

Uncoated microfine titanium dioxide is available from Degussa under the trade designation P25 and from Teikoku Kako Co. Ltd. under the trade designation MT150W. Titanium dioxide coated with aluminium stearate is available from Teikoku Kako Co. Ltd. under the trade designation MT100T. This last mentioned material is hydrophobic whereas the uncoated materials i are not. The amount of titanium dioxide present in any particular composition according to the present Sinvention depends on the use for which the composition 20 is intended. Amounts as low as 1% may be sufficient in the so-called suntanning products which are not intended to prevent the sun's rays reaching the skin whereas the so-called sunblocks which are intended to prevent substantially all of the sun's rays reaching the skin may require levels of 15 to 20%. Sunscreen compositions will more usually contain 2.5 to 10% of titanium dioxide.

i* Other sunscreening agents may be incorporated into the compositions of the present invention. Examples of S" 30 suitable further sunscreening agents include a) p-aminobenzoic acids, its esters and derivatives (for example, 2-ethylhexyl p-dimethylaminobenzoate), b) methoxycinnamate esters (for example, 2-ethylhexyl S-methoxycinnamate, 2-ethoxyethyl p-methoxycinnamate or a,p-di-(p-methoxycinnamoyl)-a'-(2-ethylhexanoyl)glycerin), c) benzophenones (for example oxybenzone),

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it I- i; -3d) dibenzoylmethanes and e) salicylate esters. Any additional sunscreening agent is present in an amount from 0.1 to 10% by weight of the composition.

The oil phase of the water-in-oil emulsions of the present invention may comprise a) hydrocarbon oils such as paraffin or mineral oils, b) waxes such as beeswax or paraffin wax, c) natural oils such as sunflower oil, apricot kernel oil, shea butter or jojoba oil, d) silicone oils such as dimethicone, cyclomethicone or cetyldimethicone or e) mixtures thereof. In preferred compositions of the present invention the oil phase comprises 10-50, more preferably 20 to 40% of the composition. It has been found that compositions in which the oil phase comprises silicone oils or a 15 mixture of silicone oils and hydrocarbon oils and waxes .are particularly effective in the sunscreening test o described in detail hereinafter.

The emulsifiers used may be any emulsifiers known in the art for use in water-in-oil emulsions. It has 20 been found that particularly effective sunscreen compositions can be prepared by using an emulsifier or mixture of emulsifiers selected from a) sesquioleates such as polyglyceryl-2-sesquioleate (available commercially for example under the trade name Hostacerin WO) or sorbitan sesquioleate (available commercially for example under the trade name Arlacel 83), b) ethoxylated esters of derivatives of natural oils such as the polyethoxylated ester of hydrogenated castor oil (available commercially for example under the trade name Arlacel 989), c) silicone emulsifiers such as silicone polyols (available commercially for example under the trade name ABIL WS08) or d) mixtures thereof. The amount of emulsifier present in the compositions of the present invention is preferably in 'g 35 the range 2-10%. In preferred compositions of the -i- S- 17 Components 1 to 4 were mixed and heated to 70 0

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qnd th- tit-,;aniiium dioxide disnersed therein usina a high -4present invention the emulsifier is a mixture of polyglyceryl-2-sesquioleate and polyethoxylated esters of hydrogenated castor oil. In particularly preferred compositions of the present invention the emulsifier is a silicone polyol.

The compositions of the present invention may additionally comprise other components which will be well known to those skilled in the art for example emolients such as isopropyl myristate or a triglyceride of a fatty acid lauric triglyceride or capric/caprylic triglyceride), humectants such as glycerin or 1 ,3-butyleneglycol, antioxidants such a DL-A-tocopherylacetate or butylated hydroxytoluene, emulsion stabilising salts such as sodium chloride, 15 film formers to assist spreading on the surface of the skin such as alkylated polyvinylpyrrolidone, preservatives such as bronopol isothiazolone or diazolidinylurea, perfumes and colouring.

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The efficacy of the compositions may be measured in user tests, i.e. in vivo, or, more conveniently, in a model system disclosed by Dr. M. Stockdale at the e: 0Joint Symposium of the Society of Cosmetic Scientists and the Societe Francaise de Cosmetologie, held in Stratford, UK in April 1986 and subsequently published in the International Journal of Society of Cosmetic Scientists 9 pp 85-98 (1987). Essentially, a cast of human skin is taken so that the topography of the skin is reproduced exactly. The first (negative) cast is made from silicone rubber and then a second (positive) 0 30 cast is made from an ultraviolet (UV) transparent material such as Luviset CAP-X (BASF) in ethanol.

Luviset CAP-X is a hair lacquer. UV light from 900W Xenon Arc Clinical Photo-Irradiator (Applied Photophysics Ltd.) is supplied via a 1m x 5mm flexible 11 71 P 17, I I i; i: i :i; 5 light guide (Applied Photophysics Ltd.) and passed through the second cast to give a 2cm diameter beam on a thermopile or a UV-310 sensor coupled to a UVX Radiometer (Ultra Violet Products Inc., USA) The product to be tested was dispensed onto the second cast and evenly spread on the surface of the cast. A protection index can then be derived by dividing (Detector reading without the product) by (Detector reading with the product).

The invention is illustrated by the following Examples 1 to 11 which are formulated as water-in-oil emulsions. Examples 1 to 11 are given by way of example only. Comparative Examples A to E form no part of the present invention and are formulated as 15 'oil-in-water emulsions. The results of tests performed as described above to determine the protection index are given below and it can be seen that the Examples illustrating compositions of the present invention show a much higher protection index than is obtained with the Comparative Examples.

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00::: 5050 50 0S: 0 0* 00 0*O 0 00* S- 00 -i ;i i ie i; ed 1~ r-jg A: I I C 18 The claims defining this invention are as follows: 1

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Protection Indcex 6 3 6 4 14 8 16 9 improvement 120% 100% 100% 78%

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1) A mixture of polyglyceryl-2-sesquioleate, beeswax, mineral oil, magnesium stearate and aluminium stearate (sold under the trade name Hostacerin WO) 20 2) Polyoxyethylene ester of hydrogenated castor oil (sold under the trade name Arlacel 989) 3) White Soft Paraffin 4) Liquid Paraffin 5) Alkylated polyvinylpyrrolidone (sold under the trade name Unimer U151) 6) Isopropyl myristate 6 3% 8% 21.

14% I-i 19 8. k sunscreen composition as claimed in any one of -7- 7) Titanium dioxide (sold under the trade designation 8) Purified water to 100% Components 1 to 6 were mixed together and heated o 70°C and the titanium dioxide (component 7) dispersed in the mixture using a high shear mixer/homogeniser (Silverson). The water heated to was added slowly with stirring. The resulting mixture was homogenised using a high shear/mixer homogeniser to give a cream.

Example 2 1) A mixture of polyglyceryl-2-sesquioleate, beeswax, mineral oil, magnesium stearate 6% and aluminium stearate (sold under the trade name Hostacerin WO) 2) Polyoxyethylene ester of hydrogenated castor oil (sold under the trade name 3% Arlacel 989) i. 3) White Soft Paraffin 4) Liquid Paraffin 6%

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5) Alkylated polyvinylpyrrolidone (sold under the trade name Unimer U151) 2% 6) Isopropyl myristate 9% 7) Titanium dioxide (sold under the trade 25 designation 8) Purified water to 100% U S The above components were formulated as described in Example 1 to give a cream.

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20 sesquioleate and a polyethoxylated ester of hydrogenated castor oil.

Example 3 1) A mixture of polyglyceryl-2-sesquioleate, beeswax, mineral oil, magnesium stearate and aluminium stearate (sold under the trade name Hostacerin WO) 2) Polyoxyethylene ester of hydrogenated castor oil (sold under the trade name Arlacel 989) 3) White Soft Paraffin 4) Liquid Paraffin Alkylated polyvinylpyrrolidone (sold under the trade name Unimer U151) 6) Isopropyl myristate 7) Titanium dioxide (sold under the trade designation MT100T) 8) Purified water t 8% 2% 14% o 100% 9 *.9 *999 9 999 9 999999 The above components were formulated as described in Example 1 to give a cream.

Example 4 20 1) A mixture of polyglyceryl-2-sesquioleate, beeswax, mineral oil, magnesium stearate and aluminium stearate (sold under the trade name Hostacerin WO) 2) Polyoxyethylene ester of hydrogenated castor oil (sold under the trade name Arlacel 989) 3) White Soft Paraffin 4) Liquid Paraffin Alkylated polyvinylpyrrolidone (sold under the trade name Unimer U151) 6) Isopropyl myristate 7) 2-ethylhexyl p-dimethylaminobenzoate 6% 3% 8% 2% 4% -9- (sold under the trade name Escalol 507) 8) Titanium dioxide (sold under the trade designation MT'00T) 9) Purified water to 100% Components 1 to 7 were mixed together and heated to 70 0 C and the titanium dioxide (component 8) dispersed in the mixture using a high shear mixer/homogeniser (Silverson). The water heated to was added slowly with stirring. The resulting mixture was homogenised using a high shear/mixer homogeniser to give a cream.

Example 1) A mixture of polyglyceryl-2-sequiolate, beeswax, mineral oil, magnesium stearate 5.4% and aluminium stearate (sold under the trade name Hostacerin WO) 2) Polyoxyethylene ester of hydrogenated castor oil (sold under the trade name 2.7% a. Arlacel 989) 3) Isopropyl myristate 4) Cetyl dimethicone (sold under the trade name ABIL 9801) 8% 5) Dimethicone silicone fluid (30000 cps) 1% 6) 2-ethylhexyl p-dimethylaminobenzoate (sold 25 under the trade name Escalol 507) 4% 7) Cyclomethicone (sold under the trade S* name Dow Corning 344) 2% 8) Siliconised talc 2% 9) A mixture of liquid paraffin and polyethylene (sold under the trade name Pionier PLW) Titanium dioxide (sold under the trade 10 designation MT 100T) 8% 11) Purified water to 100% Components 1 to 9 were mixed together and heated I to 70°C and the titanium dioxide (component dispersed in the mixture using a high shear mixer/homogeniser (Silverson). The water heated to was added slowly with stirring. The resulting mixture was homogenised using a high shear/mixer homogeniser to give a cream, Example 6 1) Silicone polyol (sold under the trade name ABIL WS08) 2) Isopropyl myristate 9% 3) Light liquid paraffin 6% 4) Sunflower oil 3% 5) Cyclomethicone (sold under the trade name Dow Corning 344) 4% 6) Glycerin 2% 7. 7) Titanium dioxide (sold uner the trade designation P25) 8) Purified water to 100% So Components 6 and 8 were mixed together and added 5 very slowly with stirring to Components 1 to 5 which had been previously mixed together. The titanium dioxide (Component 7) was then dispersed into the mixture using a high shear mixer/homogeniser (Silverson) to give a cream.

Example 7 1) Isopropyl myristate 9% 2) Light liquid paraffin 6% U 11 3) White soft paraffin 4) Silicone polyol (sold under the trade name ABIL WS08) Cyclomethicone (sold under the trade name Dow Corning 344) 6) Sodium chloride 7) Glycerin 8) Titanium Dioxide (sold under the tiade designation MT150W) 9) Purified water 3% 4% 2% to 100% Components 1 to 5 were mixed together and the titanium dioxide dispersed in the mixture using a high shear mixer/homogeniser (Silverson). The water, sodium chloride and glycerin were mixed and added slowly with stirring. The resulting mixture was homogenised to give a light cream/lotion.

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4 4 4I 44~ 4, r4: Example 8 1) Isopropyl myristate 2) White soft paraffin 3) Silicone polyol (sold under the trade name ABIL WSO8) 4) Cyclomethicone (sold under the trade name Dow Corning 344) 5) Sodium chloride 6) Glycerin 7) Titanium Dioxide (sold under the trade designation MT150W) 8) Purified water 9% 3% 4% 2% to 100% 25 The above components were formulated as in Example 30 7 to give a light cream/lotion.

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12 Example 9 1) Isopropyl myristate 2) Light liquid paraffin 3) White soft paraffin 4) Silicone polyol (sold under the trade name ABIL WSO8) Cyclomethicone (sold under the trade name Dow Corning 344) 6) Sodium chloride 7) Glycerin 8) Titanium Dioxide (sold under the trade designation MT100T) 9) Purified water 9% 6% 3% 4 2% to 100% The above components were formulated as 7 to give a light cream/lotion.

in Example 9 4, ~4 0I a Ia 4 U a 0 44 U 46 4* Example S*

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1a* *n maae 1) Microcrystalline wax (sold under the trade name Okerin 239) 2) Silicone polyol (sold under the trade 20 name ABIL WS08) 3) White soft paraffin 4) Light liquid paraffin 5) Apricot Kernel Oil 6) Cyclomethicone (sold under the trade name Dow Corning 345) 7) Cetyl dimethicone (sold under the trade name ABIL 9801) 8) Titanium Dioxide (sold under the trade designation MT100T) 9) Glycerin Sodium chloride 11) Isothiazolone E (sold under the trade name Kathon CG) 2% 3% 3% 1% 2% 0.05% 13 12) Diazolidinyl urea (sold under the trade name Germall II) 0.2% 13) Purified water to 100% The above components were formulated as described in Example 7 except that the preservatives (Components 11 and 12) were incorporated into the water phase and the resulting product was a heavy cream.

Example 11 9.

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1) Sorbitan sesquioleate (sold under the trade name Arlacel 83) 2) Trilaurin (a triglyceride of lauric acid sold under the trade name Softisan 100) 3) White soft paraffin 4) Shea Butter 5) Jojoba oil 6) Capric/caprylic triglyceride (sold under the trade name Miglyol 810) 7) 2-Ethylhexyl p-methoxycinnamate (sold under the trade name Parsol MCX) 8) DL-A-Tocopheryl Acetate 9) Butylated hydroxytoluene A mixture of cyclomethicone and dimethicone copolyol (sold under the trade name Dow Corning 3225C) 11) Cyclomethicone (sold under the trade name Dow Corning 345) 12) Dimethicone (sold under the trade name F111/100) 13) Titanium dioxide (sold under the trade designation MT100T) 14) Sodium citrate Sodium pyrrolidone carboxylate (sold under the trade name Ajidew N'0) 3 6 3 1 0.08 12 8 2 1 1 i^' r

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14 Bronopol Glycerin 1,3-Butylene glycol Purified water 0.02 2 1 to 100 Components 1 to 12 were mixed and heated to and the titanium dioxide dispersed in the mixture using a high shear mixer/homogeniser (Silverson). Components 14 to 19 were mixed and added slowly with stirring.

The resulting mixture was homogenised to give a lotion.

Comparative Example A 9 o io I 9.

9 9- 99 999999 1) Ethoxylated stearyl alcohol (sold under the trade name Brij 72) 2) Ethoxylated (21) stearyl alcohol (sold under the trade name Brij 721) 3) Cetyl alcohol 4) Light liquid paraffin 5) Dimethicone (30000 cps) 6) 1,3-Butylene glycol 7) Film-forming humectant (sold under the 20 the trade name Lubrajel) 8) Titanium Dioxide (sold under the trade designation P25) 9) Purified water 2 1 3 7 3 2 to 100 Components 1 to 6 were mixed and heated to 25 and the titanium dioxide dispersed therein using a high shear/mixer homogeniser (Silverson). Components 7 and 9 were mixed, heated to 70°C and added to the remaining ingredients with stirring. The resulting mixture was homogenised to give a cream.

Comparative Example B 1) Cetostearyl alcohol

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~i ;i _i r p compositions of the present invention but the 3) Ethoxylated (20) stearyl alcohol (sold under the trade name Volpo CS20) 2 4) Liquid paraffin 1 Hydroxyethylcellulose (sold under the trade name Natrosol 250HHR) 0.2 6) Titanium dioxide (sold under the trade designation P25) 7) Purified water to 100 Components 1 to 4 were mixed and heated to and the titanium dioxide dispersed therein using a high shear mixer/homogeniser (Silverson). Components 5 and 7 were mixed, heated to 70 0 C and added to the remaining ingredients with stirring. The resulting mixture was homogenised to give a cream.

•Comparative Example C 1) Ethoxylated stearyl alcohol (sold under the trade name Brij 72) 2 20 2) Ethoxylated (21) stearyl alcohol (sold under the trade name Brij 721) 1 3) Cetyl alcohol 3 4) Light liquid paraffin 7 5) 1 ,3-Butylene glycol 3 25 6) Titanium dioxide (sold under the trade designation MT150W) 7) Purified water to 100 Components 1 to 4 were mixed and heated to and the titanium dioxide dispersed therein using a high "O mni 30 shear mixer/homogeniser (Silverson). Components 5 and 7 were mixed, heated to 70 0 C and added to the remaining ingredients with stirring. The resulting mixture was .homogenised to give a soft cream/lotion.

4 1 1 1 1 1'6 Comparative Example D 1) Ethoxylated stearyl alcohol (sold under the trade name Brij 72) 2) Ethoxylated (21) stearyl alcohol (sold under the trade name Brij 721) 3) Cetyl alcohol 4) Light liquid paraffin 1,3-Butylene glycol 6) Titanium dioxide (sold under the trade designation MT150W) 7) Purified water 2 1 3 7 3 to 100 Components 1 to 4 were mixed and heated to and the titanium dioxide dispersed therein using a high shear mixer/homogeniser (Silverson). Components 5 and 7 were mixed, heated to 70°C and added to the remaining ingredients with stirring. The resulting mixture was homogenised to give a soft cream/lotion.

Comparative Example E 0 0* 0 *0 0 5 5* *0*00* 5000 050555i Al 25 1) Ethoxylated stearyl alcohol (sold under the trade name Brij 72) 2) Light liquid paraffin 3) Ethoxylated (21) stearyl alcohol (sold under the trade name Brij 721) 4) White soft paraffin 5) 1,3-Butylene glycol 6) Titanium dioxide (sold under the trade designation 7) Acrylic acid polymer (sold under the trade name Carbopol 430) 8) Potassium hydroxide 9) Purified water to pH 7 to 100 the range 2-10%, In preferred compositions of the 17 Components 1 to 4 were mixed and heated to 70 0

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and the titanium dioxide dispersed therein using a high shear mixer/homogeniser (Silverson), Components 5, 7, 8 and 9 were mixed, heated to 70°C and added to the remaniing ingredients with stirring. The resulting mixture was homogenised to give a cream.

Comparative Example F 1) Polyglycol ceto stearate (sold under the trade name Tefose 1500) 2) Titanium dioxide (sold under the trade designation MT100T) 3) Isopropyl myristate 4) Light liquid paraffin 2 Polyglycerol C 12

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1 8 triglyceride (sold under the trade name Labrafil M2130 CS) 3 7) Stearic acid 1 8) Glycerin 9) Purified water to 100 Components 1, 3, 4, 5 and 6 were mixed and heated to 70°C and the titanium dioxide dispersed therein using a high shear mixer/homogeniser (Silverson).

Components 7 and 8 were mixed, heated to 70°C and added to the remaining ingredients with stirring. The 25 resulting mixture was homogenised to give a heavy cream.

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Claims

1. A sunscreen composition compr'i,'sing a water-in-oil emulsion which comprises a) 0.5 to 30% by weightof titanium dioxide having a mean primary particle size of less than lOm, b100nm by weight of an oil phase, c) 1 to 15% by weight of an emulsifier, and d) at least by weight of an aqueous phase.

2. A sunscreen composition as claimed in claim 1 wherein the mean primary particle size of the titanium dioxide is between 1 and OOnm.

3. A sunscreen composition as claimed in claim 1 wherein the mean primary particle size of the titanium dioxide is between 5 an 5Onm.

4. A sunscreen composition as claimed in any one of the preceding claims wherein the titanium dioxide particles are coated with aluminium stearate.

5. A sunscreen composition as claimed in any one of the preceding claims wherein the composition comprises 2.5 to 10% of titanium dioxide.

6. A sunscreen composition as claimed in any one of the preceding claims wherein the composition contains 0.1 to 10% of a further sunscreening agent.

7. A sunscreen composition as claimed in claim 6 wherein the further sunscreening agent is selected from a) p-aminobenzoic acids and esters and derivatives thereof, b) methoxycinnamate esters c) benzophenones, d) dibenzoylmethanes and e) salicylate esters. the pre hydroc a and mixi 5 A wherein beeswax oil, 10 10. A the pre to C: see... C: e S

11. A *a e S S S. *0 **r C; S S C: eq C S., Ce S C 0O SC.. 55 e* e;,

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555. 0* S 55: 5 *5 See see. 20 hydroge: mixture 13. A wherein C *e C:: CeS C C 'BA wn -19- 8. A sunscreen composition as claimed in any one of the preceding claims wherein the oil phase comprises hydrocarbon oils, waxes, natural oils, silicone oils and mixtures thereof. 9. A sunscreen composition as claimed in claim 8 wherein the oil phase comprises paraffin, mineral oil, beeswax, paraffin wax, sunflower oil, apricot kernel oil, shea butter, jojoba oil, dimethicone, cyclomethicone, cetyldimethicone or mixtures thereof. 10. A sunscreen composition as claimed in any one of the preceding claims wherein the emulsifier comprises 2 to 10% of the composition. 11. A sunscreen composition as claimed in claim 10 wherein the emulsifier is selected from sesguioleates, ethoxylated esters of derivatives of natural oils, silicone emulsifiers or mixtures thereof. 12. A sunscreen composition as claimed in claim 11 wherein the emulsifier is polyglycerol-2-sesquioleate, sorbitan sesquioleate, a polyethoxylated ester of hydrogenated castor oil or a silicone polyol or mixtures thereof. 13. A sunscreen composition as claimed in claim wherein the emulsifier is a mixture of polyglycerol-2- .9 O 999 o. o9 O 9' Y t y y t7 R 4 1 Sec.i^ .,77 t IN 1. 20 sesquioleate and a hydrogenated castor oil. polyethoxylated ester of 14. A sunscreen as claimed in claim 10 wherein emulsifier is a silicone polyol. the 9 9* 4~ S 0 p. 9 909 9P*p9) 0 9 Ll~f in:- i :-ry II CLry-, n~ i. I 21 S 1T.. A sunscreen composition as claimed in claim 1, substantially as hereinbefore described with reference to the Examples. disclosed herein or referred to or india-t-e in the specification and/or clai s-e his application, individuall -r-co lectively, and any and all combinations DATED this TWELFTH day of OCTOBER 1988 4 4 V 0 4. S.: 04 0 00 a JA 4 4* 14 r4 The Boots Company PLC by DAVIES COLLISON Patent Attorneys for the applicant(s) N AS iy