AU6632094A - Enhanced triple-helix and double-helix formation with oligomers containing modified purines - Google Patents

Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Info

Publication number
AU6632094A
AU6632094A AU66320/94A AU6632094A AU6632094A AU 6632094 A AU6632094 A AU 6632094A AU 66320/94 A AU66320/94 A AU 66320/94A AU 6632094 A AU6632094 A AU 6632094A AU 6632094 A AU6632094 A AU 6632094A
Authority
AU
Australia
Prior art keywords
helix
double
containing modified
oligomers containing
modified purines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU66320/94A
Other languages
English (en)
Inventor
Brian Froehler
Mark Matteucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AU6632094A publication Critical patent/AU6632094A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU66320/94A 1993-04-19 1994-04-12 Enhanced triple-helix and double-helix formation with oligomers containing modified purines Abandoned AU6632094A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5069893A 1993-04-19 1993-04-19
US050698 1993-04-19
PCT/US1994/004013 WO1994024144A2 (fr) 1993-04-19 1994-04-12 Formation a helice triple et double a l'aide d'oligomeres contenant des purines modifiees

Publications (1)

Publication Number Publication Date
AU6632094A true AU6632094A (en) 1994-11-08

Family

ID=21966852

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66320/94A Abandoned AU6632094A (en) 1993-04-19 1994-04-12 Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Country Status (3)

Country Link
EP (1) EP0695306A1 (fr)
AU (1) AU6632094A (fr)
WO (1) WO1994024144A2 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE4438918A1 (de) 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US5734040A (en) * 1996-03-21 1998-03-31 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
US6274313B1 (en) 1996-03-21 2001-08-14 Pioneer-Hybrid International, Inc. Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US6331617B1 (en) 1996-03-21 2001-12-18 University Of Iowa Research Foundation Positively charged oligonucleotides as regulators of gene expression
WO1998000433A1 (fr) * 1996-07-03 1998-01-08 President And Fellows Of Harvard College Empreinte d'interference orientee vers la matrice pour contacts proteine-adenine
USRE44779E1 (en) 1997-03-07 2014-02-25 Santaris Pharma A/S Bicyclonucleoside and oligonucleotide analogues
DE19842527A1 (de) * 1998-09-18 2000-03-23 Friedrich Schiller Uni Jena Bu Verfahren zur Bildung tripelhelixbildender Oligomere und deren Verbindungen
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
AU2001247414A1 (en) 2000-03-14 2001-09-24 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US7070933B2 (en) 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
US7144868B2 (en) 2003-10-27 2006-12-05 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
WO2005044835A1 (fr) 2003-10-27 2005-05-19 Genelabs Technologies, Inc. Procedes de preparation de derives 7-(2'-$g(b)-d-ribofuranosyl substitue)-4-(nr2r3)-5-(ethyn-1-yl substitue)-pyrrolo[2,3-d]pyrimidine
US7202223B2 (en) 2003-10-27 2007-04-10 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
JP2007509939A (ja) 2003-10-27 2007-04-19 ジェネラブズ テクノロジーズ インコーポレーティッド ウイルス感染を治療するためのヌクレオシド化合物
US7244713B2 (en) 2003-10-27 2007-07-17 Genelabs Technologies, Inc. Nucleoside compounds for treating viral infections
CA2660232C (fr) 2006-08-08 2019-05-21 Gunther Hartmann Structure et utilisation d'oligonucleotides 5'-phosphate
EP2171088B1 (fr) 2007-06-19 2015-10-14 Stratos Genomics Inc. Séquençage d'acides nucléiques à haut rendement par expansion
WO2009035438A1 (fr) * 2007-09-13 2009-03-19 Janos Borbely Nanoparticules polymériques obtenues par interactions ion-ion
EP2297323A1 (fr) 2008-05-21 2011-03-23 Hartmann, Gunther Oligonucléotide à 5 -triphosphate présentant une extrémité franche et ses utilisations
WO2010088557A1 (fr) 2009-01-29 2010-08-05 Stratos Genomics Inc. Séquençage d'acide nucléique haut rendement par expansion et procédés associés
TW201102390A (en) 2009-03-31 2011-01-16 Arqule Inc Substituted pyrazolo-pyrimidine compounds
US8586301B2 (en) 2010-06-30 2013-11-19 Stratos Genomics, Inc. Multiplexed identification of nucleic acid sequences
EP2508530A1 (fr) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification d'oligonucléotides triphosphorylés au moyen d'étiquettes de capture
US9212392B2 (en) 2012-09-25 2015-12-15 Exact Sciences Corporation Normalization of polymerase activity
EP2712870A1 (fr) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Nouveaux ligands de RIG-I et procédés pour les produire
US20140287946A1 (en) 2013-03-14 2014-09-25 Ibis Biosciences, Inc. Nucleic acid control panels
US10301345B2 (en) 2014-11-20 2019-05-28 Stratos Genomics, Inc. Phosphoroamidate esters, and use and synthesis thereof
CN107427529A (zh) 2014-12-26 2017-12-01 埃莫里大学 N4‑羟基胞苷和衍生物及与其相关的抗病毒用途
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
WO2017087281A1 (fr) 2015-11-16 2017-05-26 Stratos Genomics, Inc. Variants de polymérase de type dpo4
WO2017192221A1 (fr) 2016-05-05 2017-11-09 Exact Sciences Corporation Détection de néoplasie pulmonaire par analyse d'adn méthylé
CA3049459A1 (fr) 2017-01-27 2018-08-02 Exact Sciences Development Company, Llc Detection de la neoplasie du colon par analyse d'adn methyle
CA3061651A1 (fr) 2017-05-04 2018-11-08 Stratos Genomics, Inc. Variants de polymerase de type dp04
KR102626210B1 (ko) 2017-12-07 2024-01-18 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
JP7288457B2 (ja) 2017-12-11 2023-06-07 ストラトス ゲノミクス インコーポレイテッド 正確性が向上したｄｐｏ４ポリメラーゼバリアント
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
GB2605952A (en) * 2021-04-12 2022-10-26 Stealth Labels Biotech Ab Fluorescent nucleoside triphosphates
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
WO2023278781A1 (fr) 2021-07-01 2023-01-05 Illumina, Inc. Dispositif ayant un nanocanal horizontal pour le séquençage de nanopores
EP4396376A1 (fr) 2021-09-01 2024-07-10 Illumina, Inc. Modulation d'amplitude pour identification de base accélérée
AU2022349615A1 (en) 2021-09-22 2024-01-18 Illumina, Inc. Sequencing polynucleotides using nanopores
US20230112203A1 (en) 2021-09-30 2023-04-13 Illumina, Inc. Isolation of cells in a nanopore sensor array
US20240319165A1 (en) 2021-11-15 2024-09-26 Illumina, Inc. Nanopore systems and methods of fabrication
US20230183799A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
WO2023175041A1 (fr) 2022-03-15 2023-09-21 Illumina, Inc. Séquençage simultané des brins sens et antisens du complément sur des polynucléotides concaténés
US20230357307A1 (en) 2022-05-04 2023-11-09 Illumina, Inc. Cleavable cyclic loop nucleotides for nanopore sequencing
WO2023239660A1 (fr) 2022-06-07 2023-12-14 Illumina Software, Inc. Procédés et systèmes d'identification de variants géniques
WO2024010809A2 (fr) 2022-07-07 2024-01-11 Illumina Software, Inc. Méthodes et systèmes de détection d'événements de recombinaison
WO2024010812A2 (fr) 2022-07-07 2024-01-11 Illumina Software, Inc. Procédés et systèmes de détermination de génotypes de variants de nombre de copies
WO2024073278A1 (fr) 2022-09-26 2024-04-04 Illumina, Inc. Détection et génotypage de répétitions en tandem à nombre variable
WO2024072685A1 (fr) 2022-09-28 2024-04-04 Illumina, Inc. Impulsions rapides pour capteurs à nanopores
WO2024163233A1 (fr) 2023-01-31 2024-08-08 Illumina, Inc. Appel et récupération d'une variation du nombre de copies
WO2024191730A1 (fr) 2023-03-10 2024-09-19 Illumina, Inc. Procédés à base de k-mer pour l'assemblage de séquences polynucléotidiques

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337530A (en) * 1965-09-20 1967-08-22 Upjohn Co Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety
US3309358A (en) * 1965-09-20 1967-03-14 Upjohn Co 7-deazaadenine 2', 5'-and 3', 5'-dinucleoside phosphate and process therefor
US3962211A (en) * 1975-01-13 1976-06-08 The University Of Utah 7-substituted nucleoside compounds
PT71393B (en) * 1979-06-14 1981-10-22 Wellcome Found Antiprotozoal agents
US4352795A (en) * 1981-01-29 1982-10-05 Warner-Lambert Company 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
WO1989012380A2 (fr) * 1988-06-09 1989-12-28 Temple University Of The Commonwealth System Of Hi Utilisations therapeutiques de derives de 2,5'-oligoadenylate
WO1990003370A1 (fr) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVES DE PYRAZOLO[3,4-d]PYRIMIDINE
EP0450102A4 (en) * 1989-10-26 1992-05-06 Yamasa Shoyu Kabushiki Kaisha Nucleoside derivative
JPH06509945A (ja) * 1991-08-19 1994-11-10 マイクロプローブ・コーポレイション 酵素媒介三本鎖形成のための架橋性オリゴヌクレオチド
WO1993009127A1 (fr) * 1991-11-07 1993-05-13 Gilead Sciences, Inc. Formation amelioree d'une triple helice, grace a des oligonucleotides contenant la 2'-desoxy-7-desazaxanthosine, la 2'-desoxy-7-desazaguanosine et des composes analogues
DE4140463A1 (de) * 1991-12-09 1993-06-17 Boehringer Mannheim Gmbh 2'-desoxy-isoguanosin, dessen isostere analoge sowie anwendung derselben

Also Published As

Publication number Publication date
EP0695306A1 (fr) 1996-02-07
WO1994024144A3 (fr) 1995-03-16
WO1994024144A2 (fr) 1994-10-27

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