AU662640B2 - Substituted aminothienopyridines, a process for their preparation and their use as medicaments - Google Patents

Substituted aminothienopyridines, a process for their preparation and their use as medicaments

Info

Publication number
AU662640B2
AU662640B2 AU42001/93A AU4200193A AU662640B2 AU 662640 B2 AU662640 B2 AU 662640B2 AU 42001/93 A AU42001/93 A AU 42001/93A AU 4200193 A AU4200193 A AU 4200193A AU 662640 B2 AU662640 B2 AU 662640B2
Authority
AU
Australia
Prior art keywords
preparation
compounds
useful
aminothienopyridines
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU42001/93A
Other versions
AU4200193A (en
Inventor
Richard C. Effland
Joseph T. Klein
Lawrence L. Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of AU4200193A publication Critical patent/AU4200193A/en
Application granted granted Critical
Publication of AU662640B2 publication Critical patent/AU662640B2/en
Assigned to HOECHST MARION ROUSSEL, INC. reassignment HOECHST MARION ROUSSEL, INC. Alteration of Name(s) in Register under S187 Assignors: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED
Assigned to AVENTIS PHARMACEUTICALS INC. reassignment AVENTIS PHARMACEUTICALS INC. Request to Amend Deed and Register Assignors: HOECHST MARION ROUSSEL, INC.
Assigned to AVENTIS HOLDINGS INC. reassignment AVENTIS HOLDINGS INC. Alteration of Name(s) in Register under S187 Assignors: AVENTIS PHARMACEUTICALS INC.
Assigned to AVENTISUB II INC. reassignment AVENTISUB II INC. Alteration of Name(s) in Register under S187 Assignors: AVENTIS HOLDINGS INC.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)

Abstract

This application relates to compounds of the formula I <CHEM> wherein R<1>, R<2>, R<3>, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists. The application relates also to a process for the preparation of the compounds of formula I.
AU42001/93A 1992-07-20 1993-07-19 Substituted aminothienopyridines, a process for their preparation and their use as medicaments Expired AU662640B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US917247 1992-07-20
US07/917,247 US5252581A (en) 1992-07-20 1992-07-20 Substituted aminothienopyridines, pharmaceutical composition and use

Publications (2)

Publication Number Publication Date
AU4200193A AU4200193A (en) 1994-01-27
AU662640B2 true AU662640B2 (en) 1995-09-07

Family

ID=25438534

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42001/93A Expired AU662640B2 (en) 1992-07-20 1993-07-19 Substituted aminothienopyridines, a process for their preparation and their use as medicaments

Country Status (13)

Country Link
US (3) US5252581A (en)
EP (1) EP0581106B1 (en)
JP (1) JP2757745B2 (en)
KR (1) KR100292212B1 (en)
AT (1) ATE166355T1 (en)
AU (1) AU662640B2 (en)
CA (1) CA2100812C (en)
DE (1) DE69318636T2 (en)
DK (1) DK0581106T3 (en)
ES (1) ES2116371T3 (en)
MX (1) MX9304353A (en)
NZ (1) NZ248170A (en)
TW (1) TW243450B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252581A (en) * 1992-07-20 1993-10-12 Hoechst-Roussel Pharmaceuticals Inc. Substituted aminothienopyridines, pharmaceutical composition and use
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
EP0599697A1 (en) * 1992-11-24 1994-06-01 Synthelabo Pyrrole derivatives, their preparation and application in therapy
US5334596A (en) * 1993-05-11 1994-08-02 Merck & Co., Inc. Fibrinogen receptor antagonists
US20070197651A1 (en) * 1998-03-09 2007-08-23 Tufts University Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
EP1061924A1 (en) * 1998-03-09 2000-12-27 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
US20060167114A1 (en) * 1998-03-09 2006-07-27 Louis Shuster Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US7875627B2 (en) 2004-12-07 2011-01-25 Abbott Laboratories Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
KR20080052630A (en) * 2005-09-01 2008-06-11 어레이 바이오파마 인크. Raf inhibitor compounds and methods of use thereof
RU2008139599A (en) 2006-03-07 2010-04-20 Эррэй Биофарма Инк. (Us) Heterobicyclic pyrazole derivatives and methods for their use
JP2013519685A (en) 2010-02-11 2013-05-30 ヴァンダービルト ユニバーシティー Benzisoxazoles and azabenzisoxazoles as mGluR4 allosteric enhancers, compositions, and methods of treating neurological dysfunction
JP5102401B1 (en) 2012-03-30 2012-12-19 森下仁丹株式会社 Large intestine specific disintegration capsule
US11466027B2 (en) 2019-07-03 2022-10-11 H. Lundbeck A/S Modulators of the NMDA receptor
US11358971B2 (en) 2019-07-03 2022-06-14 H. Lundbeck A/S Prodrugs of modulators of the NMDA receptor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2811527A (en) * 1955-11-16 1957-10-29 Olin Mathieson Derivatives of thieno (3, 2-b) pyridine and method of preparing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US281152A (en) * 1883-07-10 Safety-pin
NO140499C (en) * 1973-07-23 1979-09-12 Takeda Chemical Industries Ltd ANALOGICAL PROCEDURE FOR THE PREPARATION OF THIENOPYRIDINE CARBOXYLIC ACID RIVER CATER WITH Therapeutic ACTIVITY
US3952989A (en) * 1974-11-26 1976-04-27 Bannister Hatcher Constance L Adjustable reading material stand
FR2440738A1 (en) * 1978-11-13 1980-06-06 Parcor Antiinflammatory, analgesic thieno:pyridine(s) - prepd. by treating a 3-bromo-thieno-pyridine with cuprous cyanide, and opt. hydrolysing
US5026698A (en) * 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones
US5252581A (en) * 1992-07-20 1993-10-12 Hoechst-Roussel Pharmaceuticals Inc. Substituted aminothienopyridines, pharmaceutical composition and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2811527A (en) * 1955-11-16 1957-10-29 Olin Mathieson Derivatives of thieno (3, 2-b) pyridine and method of preparing same

Also Published As

Publication number Publication date
US5252581A (en) 1993-10-12
NZ248170A (en) 1995-12-21
ATE166355T1 (en) 1998-06-15
MX9304353A (en) 1994-02-28
DE69318636T2 (en) 1998-11-26
ES2116371T3 (en) 1998-07-16
EP0581106A1 (en) 1994-02-02
KR100292212B1 (en) 2001-09-17
US5856335A (en) 1999-01-05
CA2100812A1 (en) 1994-01-21
DK0581106T3 (en) 1999-02-15
KR940002249A (en) 1994-02-17
JPH06179681A (en) 1994-06-28
TW243450B (en) 1995-03-21
DE69318636D1 (en) 1998-06-25
JP2757745B2 (en) 1998-05-25
US5519032A (en) 1996-05-21
AU4200193A (en) 1994-01-27
CA2100812C (en) 2006-11-14
EP0581106B1 (en) 1998-05-20

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired
NA Applications received for extensions of time, section 223

Free format text: AN APPLICATION TO EXTEND THE TIME FROM 20010719 TO 20020519 IN WHICH TO PAY A RENEWAL FEE HAS BEEN LODGED

NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO PAY A RENEWAL FEE HAS BEEN EXTENDED TO 20020519

MK14 Patent ceased section 143(a) (annual fees not paid) or expired