AU658853B2 - Improved agglutination reaction device utilizing selectively impregnated porous material - Google Patents
Improved agglutination reaction device utilizing selectively impregnated porous materialInfo
- Publication number
- AU658853B2 AU658853B2 AU90747/91A AU9074791A AU658853B2 AU 658853 B2 AU658853 B2 AU 658853B2 AU 90747/91 A AU90747/91 A AU 90747/91A AU 9074791 A AU9074791 A AU 9074791A AU 658853 B2 AU658853 B2 AU 658853B2
- Authority
- AU
- Australia
- Prior art keywords
- layer
- chamber
- impregnated
- liquid
- well
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/112499—Automated chemical analysis with sample on test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/614,762 US5209904A (en) | 1987-12-23 | 1990-11-16 | Agglutination reaction device utilizing selectively impregnated porous material |
| US614762 | 1990-11-16 | ||
| PCT/US1991/008548 WO1992008974A1 (en) | 1990-11-16 | 1991-11-15 | Improved agglutination reaction device utilizing selectively impregnated porous material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU9074791A AU9074791A (en) | 1992-06-11 |
| AU658853B2 true AU658853B2 (en) | 1995-05-04 |
Family
ID=24462601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU90747/91A Ceased AU658853B2 (en) | 1990-11-16 | 1991-11-15 | Improved agglutination reaction device utilizing selectively impregnated porous material |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5209904A (Direct) |
| EP (1) | EP0557429A4 (Direct) |
| AU (1) | AU658853B2 (Direct) |
| CA (1) | CA2100364A1 (Direct) |
| TW (1) | TW201820B (Direct) |
| WO (1) | WO1992008974A1 (Direct) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US5468648A (en) | 1991-05-29 | 1995-11-21 | Smithkline Diagnostics, Inc. | Interrupted-flow assay device |
| US5607863A (en) | 1991-05-29 | 1997-03-04 | Smithkline Diagnostics, Inc. | Barrier-controlled assay device |
| US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| US5869345A (en) | 1991-05-29 | 1999-02-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing conductive barrier |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| JP3382632B2 (ja) * | 1992-03-13 | 2003-03-04 | オリンパス光学工業株式会社 | 生体関連物質の測定方法およびそれに用いる反応容器 |
| US5518887A (en) * | 1992-03-30 | 1996-05-21 | Abbott Laboratories | Immunoassays empolying generic anti-hapten antibodies and materials for use therein |
| US7524456B1 (en) | 1992-05-21 | 2009-04-28 | Biosite Incorporated | Diagnostic devices for the controlled movement of reagents without membranes |
| US6767510B1 (en) | 1992-05-21 | 2004-07-27 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US6905882B2 (en) * | 1992-05-21 | 2005-06-14 | Biosite, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| EP0621478B1 (en) * | 1993-04-20 | 2003-06-25 | Fuji Photo Film Co., Ltd. | Dry analytical film chip |
| US5413761A (en) * | 1994-06-09 | 1995-05-09 | Dulaney; Dolores P. | Perforated diagnostic device |
| US5668017A (en) * | 1995-02-10 | 1997-09-16 | Path | Radial absorption device |
| US5679584A (en) * | 1995-05-03 | 1997-10-21 | Mileaf; Daryl Sunny | Method for chemical detection |
| WO1996035952A1 (en) * | 1995-05-09 | 1996-11-14 | Smithkline Diagnostics, Inc. | Devices and methods for separating cellular components of blood from liquid portion of blood |
| US5541417A (en) * | 1995-05-18 | 1996-07-30 | Abbott Laboratories | Quantative agglutination reaction analysis method |
| US5879951A (en) | 1997-01-29 | 1999-03-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing unidirectional flow |
| DK2333520T3 (da) * | 1997-02-28 | 2014-09-29 | Cepheid | Varmevekslende, forespurgt indretning til kemisk reaktion |
| AU6589698A (en) * | 1997-03-28 | 1998-10-22 | Epitope, Inc. | Simultaneous collection of dna and non-nucleic analytes from oral fluids |
| US5939252A (en) | 1997-05-09 | 1999-08-17 | Lennon; Donald J. | Detachable-element assay device |
| US7713703B1 (en) | 2000-11-13 | 2010-05-11 | Biosite, Inc. | Methods for monitoring the status of assays and immunoassays |
| GB9800263D0 (en) * | 1998-01-08 | 1998-03-04 | Bio Diagnostics Ltd | A device for testing liquids |
| GB2339615B (en) * | 1998-07-14 | 2001-02-07 | Cozart Bioscience Ltd | Screening device and method of screening an immunoassay test |
| US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
| AU773679B2 (en) | 1999-07-16 | 2004-06-03 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| US7022517B1 (en) | 1999-07-16 | 2006-04-04 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| CA2401782A1 (en) | 2000-01-31 | 2001-08-02 | John T. Mcdevitt | Portable sensor array system |
| WO2002061392A2 (en) * | 2001-01-31 | 2002-08-08 | Board Of Regents, The University Of Texas System | Method and apparatus for the confinement of materials in a micromachined chemical sensor array |
| US6989891B2 (en) * | 2001-11-08 | 2006-01-24 | Optiscan Biomedical Corporation | Device and method for in vitro determination of analyte concentrations within body fluids |
| US8257967B2 (en) | 2002-04-26 | 2012-09-04 | Board Of Regents, The University Of Texas System | Method and system for the detection of cardiac risk factors |
| US6983177B2 (en) * | 2003-01-06 | 2006-01-03 | Optiscan Biomedical Corporation | Layered spectroscopic sample element with microporous membrane |
| US20040131088A1 (en) * | 2003-01-08 | 2004-07-08 | Adtran, Inc. | Shared T1/E1 signaling bit processor |
| US20050047967A1 (en) * | 2003-09-03 | 2005-03-03 | Industrial Technology Research Institute | Microfluidic component providing multi-directional fluid movement |
| US20050079484A1 (en) * | 2003-10-10 | 2005-04-14 | Heineman William Richard | Method of detecting biological materials in liquid |
| US8101431B2 (en) * | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
| US8105849B2 (en) * | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| US20060024722A1 (en) | 2004-07-30 | 2006-02-02 | Mark Fischer-Colbrie | Samples for detection of oncofetal fibronectin and uses thereof |
| WO2006047831A1 (en) * | 2004-11-03 | 2006-05-11 | Agen Biomedical Limited | Detection device and method |
| US20060194325A1 (en) | 2005-02-14 | 2006-08-31 | Gable Jennifer H | Fluid handling cassette with a fluid control interface |
| WO2007053186A2 (en) | 2005-05-31 | 2007-05-10 | Labnow, Inc. | Methods and compositions related to determination and use of white blood cell counts |
| CA2613078A1 (en) * | 2005-06-24 | 2007-01-04 | Board Of Regents, The University Of Texas System | Systems and methods including self-contained cartridges with detection systems and fluid delivery systems |
| US9561001B2 (en) | 2005-10-06 | 2017-02-07 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
| GB0611701D0 (en) * | 2006-06-14 | 2006-07-26 | Biochrom Ltd | Analytical apparatus |
| CN101578520B (zh) | 2006-10-18 | 2015-09-16 | 哈佛学院院长等 | 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法 |
| US8304254B2 (en) * | 2007-05-02 | 2012-11-06 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid onto a reagent surface |
| DK2140275T3 (en) * | 2007-05-02 | 2018-04-09 | Siemens Healthcare Diagnostics Inc | Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices |
| US20100136517A1 (en) * | 2007-05-07 | 2010-06-03 | Massachusetts Institute Of Technology | Matrix stabilization of aggregation-based assays |
| JP5309312B2 (ja) * | 2007-11-01 | 2013-10-09 | Jfeテクノス株式会社 | マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法 |
| EP2257819A4 (en) | 2008-03-27 | 2017-10-11 | President and Fellows of Harvard College | Three-dimensional microfluidic devices |
| KR20100128340A (ko) * | 2008-03-27 | 2010-12-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 종이 기반 마이크로유체 시스템 |
| CA2719322C (en) * | 2008-03-27 | 2018-11-27 | President And Fellows Of Harvard College | Cotton thread as a low-cost multi-assay diagnostic platform |
| WO2009120963A2 (en) * | 2008-03-27 | 2009-10-01 | President And Fellows Of Harvard College | Paper-based cellular arrays |
| JP5461556B2 (ja) * | 2008-08-21 | 2014-04-02 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | 尿残渣分析用多層スライド |
| TWM352684U (en) * | 2008-09-26 | 2009-03-11 | Shanghai Microtek Technology Co Ltd | Inspection apparatus for biological sample |
| PL2403645T3 (pl) | 2009-03-06 | 2017-05-31 | President And Fellows Of Harvard College | Mikroprzepływowe, elektrochemiczne urządzenia |
| US9554742B2 (en) | 2009-07-20 | 2017-01-31 | Optiscan Biomedical Corporation | Fluid analysis system |
| WO2011011462A1 (en) | 2009-07-20 | 2011-01-27 | Optiscan Biomedical Corporation | Adjustable connector and dead space reduction |
| US8696991B1 (en) | 2010-01-04 | 2014-04-15 | Harold W. Howe | Field deployable surface plasmon resonance based biosensor |
| EP2531300A1 (en) | 2010-02-03 | 2012-12-12 | President and Fellows of Harvard College | Devices and methods for multiplexed assays |
| EP3156796A1 (en) | 2010-06-09 | 2017-04-19 | Optiscan Biomedical Corporation | Measuring analytes in a fluid sample drawn from a patient |
| EP2729784A4 (en) | 2011-07-06 | 2015-05-13 | Optiscan Biomedical Corp | Measuring cell for liquid analysis system |
| US9265846B2 (en) * | 2012-11-28 | 2016-02-23 | American Sterilizer Company | Air removal test strip |
| CN104251910B (zh) * | 2013-06-29 | 2017-04-05 | 黄辉 | 一种基于光学检测的微流控芯片及其制备方法 |
| FR3012982B1 (fr) * | 2013-11-08 | 2015-12-25 | Espci Innov | Procede de stockage et de concentration d'un compose volatil |
| WO2019151468A1 (ja) * | 2018-02-02 | 2019-08-08 | 日本ケミファ株式会社 | 生化学反応用基体及び分析装置 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
| DE3134560A1 (de) * | 1981-09-01 | 1983-03-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Vorrichtung und verfahren zum steuern und mischen einer der zentrifugalkraft ausgesetzten fluessigkeitsstroemung |
| SE8305704D0 (sv) * | 1983-10-18 | 1983-10-18 | Leo Ab | Cuvette |
| US4596695A (en) * | 1984-09-10 | 1986-06-24 | Cottingham Hugh V | Agglutinographic reaction chamber |
| US4963498A (en) * | 1985-08-05 | 1990-10-16 | Biotrack | Capillary flow device |
| US4761381A (en) * | 1985-09-18 | 1988-08-02 | Miles Inc. | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
| US4906439A (en) * | 1986-03-25 | 1990-03-06 | Pb Diagnostic Systems, Inc. | Biological diagnostic device and method of use |
| US4775515A (en) * | 1986-11-18 | 1988-10-04 | Cottingham Hugh V | Agglutinographic slide |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US4857453A (en) * | 1987-04-07 | 1989-08-15 | Syntex (U.S.A.) Inc. | Immunoassay device |
| EP0321736B1 (en) * | 1987-12-23 | 1994-06-01 | Abbott Laboratories | Agglutination reaction device |
| DE3814585A1 (de) * | 1988-04-29 | 1989-11-09 | Hoffmann La Roche | Testelement fuer agglutinationsuntersuchungen, verfahren zu seiner herstellung und dessen verwendung |
-
1990
- 1990-11-16 US US07/614,762 patent/US5209904A/en not_active Expired - Fee Related
-
1991
- 1991-11-15 AU AU90747/91A patent/AU658853B2/en not_active Ceased
- 1991-11-15 EP EP19920900648 patent/EP0557429A4/en not_active Withdrawn
- 1991-11-15 CA CA002100364A patent/CA2100364A1/en not_active Abandoned
- 1991-11-15 WO PCT/US1991/008548 patent/WO1992008974A1/en not_active Ceased
-
1992
- 1992-01-29 TW TW081100683A patent/TW201820B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| US5209904A (en) | 1993-05-11 |
| AU9074791A (en) | 1992-06-11 |
| EP0557429A4 (en) | 1994-06-01 |
| TW201820B (Direct) | 1993-03-11 |
| WO1992008974A1 (en) | 1992-05-29 |
| EP0557429A1 (en) | 1993-09-01 |
| CA2100364A1 (en) | 1992-05-17 |
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