AU625310B2 - Novel compositions of mineral elements and/or oligoelements and process for their preparation - Google Patents

Abstract

The present invention relates to compositions comprising mineral elements and to their manufacturing process. The values of the physiological concentrations Cx1, Cx2, ... Cxn of these elements in the medium are determined; the values of the concentration ratios: <IMAGE> of these elements are determined; a multi-element composition is prepared, comprising at least the abovementioned elements E1, E2 ... En at concentrations C1, C2, ... Cn such that these concentrations lie within the limiting values of the ratios R1, R2, ... Rn; and the abovementioned multi-element composition is administered to a given species and by a suitable means, the composition being made into a form which is assimilable by this species.

Description

AUSTRALIA

PATENTS ACT 1952 Form COMPLETE SPECIFICATION' a (ORIGINAL) r FOR OFFICE USE Short Title: Int. Cl: Application Number: Lodged: Complete Specification-Lodged: Accepted: Lapsed: Published: S Priority: Related Art: oron 4444 4 o TO BE COMPLETED BY APPLICANT 4 t Name of Applicant: Claude CHRISTOPHE Address of Applicant: 4 RUE WALDTEUFEL o e67000 STRASBOURG o FRANCE S Actual Inventor: Address for Service; GRIFFITH HACK CO., 601 St. Kilda Road, Melbourne, Victoria 3004, SSAustralia.

Complete Specification for the invention entitled: NOVEL COMPOSITIONS OF MINERAL ELEMENTS AND/OR OLIGOELEMENTS AND PROCESS FOR THEIR PREPARATION The following statement is a full description of this invention including the best method of performing it known to me:-

IA-

NOVEL COMPOSITIONS OF MINERAL ELEMENTS AND/OR OLIGOELEMENTS AND PROCESS FOR THEIR PREPARATION BACKGROUND OF THE INVENTION The present invention relates to novel compositions of mineral elements and/or oligoelements, to a process for preparing them and to their use in human and veterinary therapy in dermato-cosmetology and in dietetics.

It is known that a certain number of mineral elements and/or oligoelements so-called essential, are 0 ovaindispensable for the living organism, both human and animal, in order to ensure a certain number of vital 9. functions of said organism, particularly as regards the various metabolisms.

The absence or insufficiency of these elements is manifested by disturbances in growth or development or particular pathologies, which can be accompanied by specific deficiency symptoms.

Among the oligoelements and inorganic elements which are essenti0 and indispensable for life, may be mentioned,for example, particularly .potassium .iodine .calcium .magnesium .zinc .selenium .copper .silicon .iron .fluorine .cobalt •bromine .nickel .sulfur ,chromium .phosphorus .vanadium .lithium .molybdenum .germanium .manganese .sodium ,rubidium .tin Ii -2- They are involved in very many functions of the organism growth (for Zn, F, Mn, Cu, Se, reproduction (Zn, Mn), dentition Mo, V), taste (Cu, Zn, Ni), erythropoiesis (Fe, Zn, Cu, Co, Mo), clotting (Mn, Cu, Zn), glucid metabolism (Cr, Mn, Zn), lipid metabolism (Cr, V, Zn, Cu), and celllular exchanges (Rb, etc...

Also many preparations containing oligoelements and/or inorganic elements have been recommended and placed on the market in the therapeutic, dietetic or dermato-cosme ologic field of use.

Said preparations, proposed in the prior art contain either one of these elements (monoelemental o o preparations), or an association of these elements (multielemental preparations).

However, said essential inorganic elements and/or oligoelements, denoted below by the term 'elements', So are mostly used in monoelemental manner, and even in *ouo' the case of multielemental associations, as a supplement in one or several deficiency conditions.

When the purpose is not directly as a supplement, said elements are associated in their indications with ideas of balance and not of pathology; in particular, as regards the 'oligosols', they contain said elements at low doses, said elements then being associated in any manner; in addition, for a limited application of an association of K, Rb and Cs to the treatment of cancer cells by high pH (BREWER et Al. in MICROBIOS.

LETT. 25 (99-100) 1984), said elements are also at very low doses and associated in any manner.

In addition, it is not known, in the prior art, to combine elements containing rubidium, which is generally described in the literature, as a biological 3 label in the form particularly of Rb 8 2 in studies relating to cellular exchanges, in the same way as other articles study the physiological transport of rubidium (BOON et Al., Br. 5, Clin Pharmacoli, 1986, 22, 1, 27-30, and Clin. Sci. (London), 1986, 70, 6, 611-616).

In the article OKADA et Al. (MED. J. THIROSHIMA UNIV., 1987, 35, 1, 36-42), the effects of rubidium on the receptors of serotonin are studied in comparison with lithium.

However, the use of rubidium in association with other elements for its particular properties on .cellular exchanges has never been envisaged in the prior art.

It is accordingly a object of the present invention to provide a pWocess for the preparation of 4 compositions comprising 'elements' having in 4 association advantageous properties in the therapeutic, dermato-cosmetological and dietetic fields.

It is, also, an object of the invention to provide compositions comprising 'elements', particularly Rb, having remarkable properties of curative or preventive treatment in human or animal medicine.

The studies of applicants have shown suprisingly that it was possible to obtain compositions of 'elements' which show quite unexpected and novel properties in their application to the human or animAl living organism, particularly for their therapeutic, dermato-cosmetological and dietetic properties.

According to the invention there is provided a -4process for the preparation of cotmpositions comprising mineral elements and/or oligoelements, so-cal'ed multielemental compositions, characterized in that there is determined, fcor a specific biological medium of a given living species and for the elements E E 2 En, finite in number, the values of the physiological concentrations CXl, Cx2,...Cxn of these elements in the medium; in that the values are determined of the ratios R R R 2 R n C xl C Cx) of concentration of said elements El E2..E, in o said medium; in that a multielemental composition is prepared comprising said elements El, E 2 En at concentrations Cl, C2.. .Cn such that said concentrations are comprised between the limiting values of the ratios RI, R2,...Rn; in that said multielemental composition is administered to a given species and by suitable means put into a form assimilable by said species.

According to an advantageous qembodiment of practising the invention, said multielemental compositions comprise at least the following elements

E

l

E

2 finite in number Rb, K, Mg, Se and Zn.

According to a preferred feature of this method, the preferred compositions conforming to said process may be administered to the given species by any one of the following routes of administration the oral, parenteral, cutaneous or peritoneal dialysis routes.

It is also an object of the present invention to provide compositions of 'elements' called multielemental compositions, characterized in that they comprise at least elements E 1

E

2 n finite in number at concentrations C 1

C

2 ?:uch that these concentrations are comprised between the limiting values of the ratios R 1

R

2 Rn defined above.

According to a preferred feature of this embodiment, said multielemental compositions comprise o"o° at least the following eleaents E Rb, K, So"% Mg, Se, Zn which constitute the basic multielemental S* composition.

According to a preferred feature of this embodiment, at least one essential mineral element and/or oligoelement are associated with the Rb, K, MG, Se and Zn.

According to an advantageous modality, said additional elements are at concentrations such as defined above.

4 *5 According to another advantageous modality, said additional elements are at concentrations independant of the ratios RI...R n as defined above, the other elemnents having concentrations comprised in ratios R Rn as defined, said composition so prepared enabling the effectiveness of the one or more additional elements to be optimized by creating a suitable environment for the activity of the one or more additional elements.

According to another preferred feature of this embodiment, at least one essential mineral element and/or oligoelement and/or cofactor are associated with the Rb, K, Mg, Se and Zn.

-6-

V

V

*VVV

I, it,, *1ti i V V it According to a preferred modality of this feature, said additional elements are at concentrations such that they present ratios n as defined above.

According to another preferred modality of this feature, said additional elements are at concentrations independant of the ratios RI...Rn as defined above.

The present invention relates in addition to medicaments containing a composition acc rding to the invention, of which the 'elements' are in the form of salts pharmaceutically acceptable and compatible with one another.

When the compositions according to the invention have, besides the elements Rb, K, Mg, Se and Zn constituting a 'basic multielemental composition', one or more of the additional elements, it has been observed that said basic composition has a synergic role on the activity of said one or more additional elements favoring a supplementary action to said one or more additional elements.

The compositions according to the invention show also a rebalancing action of the one or more additional elements added to the piultielemental basic composition.

The multielemental basic composition according to the invention has a stimul(oting action on the metabolism of adipose cells.

The compositions according to the invention may be administered alone or in combination with inert, non-toxic, supports, acceptable from the pharmaceutical point of view in solid, paste or liquid form. Among these forms may be considered tablets, S-7pastilles, capsules, pills, aqueous suspensions and solutions, creams, lotions and powders.

Applicants consider, without wishing to be bound by this indication that the surprising effects reported above are due to the action on the cellular membrane, particularly by modifying cellular exchange, of certain essential elements and particularly rubidium, preferably associated with K, Mg, Se and Zn, a will be explained below.

The invention will be better understood by means 1 of the additional description which follows, which refers to examples of comparison according to the invention as well as to reports of experiments S relating to the physiological activity of said compositions according to the invention and of the S* medicaments, cosmetological products etc. which are derived therefrom.

It must be understood, however, that these 4o, examples and accounts are given purely by way of illustration of the invention, of which they do not constitute in any way a limitation.

DESCRIPTION OF PREFERRED EMBODIMENTS 1-HUMAN BIOLOGICAL MEDIUM It is known that in the healthy man, the blood contains the aforesaid essential 'elementa' at physiological concentrations Cx such as defined below.

r 7a Element cx myj /I1 i tr e 91 1 0,25 0,30 0,30 1 0,95 4440

I

4444 4 40 4 4 4 4,44 4444

I

4444 44'' 0 4 444 44 4 4 40 4 .4 4 44 4 4 4 4 44 4 44 44 4 4 *4 0,16 3,60 0,85 0,08 0,025 0,025 173 r

V

if ii -8- For practising the invention, first the ratios R, R2, .Rn are determined in the sense given above to these ratios and thus a matrix of ratios of concentrations is obtained according to the reference element, one such matrix being seen below: 44*4 4 44 44 4 4444 ~444 4444 .44 4 4 4,44 44 4 I 4 4 44 4 44 44 4 4 44 I 44 44, In this matrix; E.denotes the element En present in the serum, Cxn denotes the concentration of the element Ell

E

2 .En in the serum.

R denotes the ratio of the concentrations of the element El/En in the serum, namely Cxr Ox 1 l In man, these rati'bs have the following values with reference to calcium.

-i~ Pr p p.' ea 0 to,' Ca Img Co Ni Cu Cr Rb Br

I

Se Mo 1 0, 79 0, 22 10 1. to- 3 0, 55. 10-3 0, 55. 10-3 1 10-2 7o 2. 10-2 4, 5. 10-4 2o,4.10o-2 6, 1. 10-2 1.10-2 0,84 10- 3 2,8B. io-4 2o,8. to-4 3, S. 10-2 -9- If, for a given multielemental composition, the all or the majority of the homol ratios between the biological medium, such as the w ,od for example, and said composition are identical, said compsition is according to the invention.

The extreme variations of the concentrations and of the ratios are defined as follows Physiological concentration of an element is comprised between -5 and +5 Standard-Deviations with respect to the mean. The extreme physiological ratios for two elements A and B, if Am and Bm are the mean concentrations in the biological reference medium of A and B, and if the SDA and S:B are the values of the Standard-Deviation for the mean of A and B for this medium, the physiological extreme values of the ratio between A and B will be Am 5 STA and Am 5 SDA 2 Bm 5 SIA Bm 5 SDA From these values, there is then prepared the following standard composition, when calcium (Ca) is taken as reference element, (se page 9a N.B. t The concentrations are expressed by weight, .a Element Cn Ca '7 353 g Mg 0,28 9 Fe 80 mg 4Mn 1 0,4 mg 1o 0, 2mg Ni 0,2 mg Cu mg Zn 25, 4mg Cr p~0g Rb 8,48 mg Br 21o6 mg 1 56 mg Se 0, 28 mg Mo 0, 1mg V 0, 1mg K 12, 3mg I-ANIMAL BIOLOGICAL MEDIUM Examples of the variations of the physiological interbalanced interelemental ratios in different species, considering calcium as a reference SPEC IES' Element_______ DOG CAT HORSE Se 6.10-3 3,2.10-3 0,3.10-3 Rb 2,4,10Q-2 4.10-2 2.10-2 'a Zn 6,10-2 60-2 3,6.10-2 44 Mg 4 ~4 K To produce a balanced rnultielemental composition accordJing to the invention and which is a physiological composition, for a given species, the ratios above must be respected.

IV- THERAPEUTIC USES IV. 1.SUPPLEMENT TREATMENTS The element to be supplemented is at -doses ot comprised within the ratios as defined, the other elements being present at concentrations such that the interelemental ratios according to the invention are respected.

-11- Example I Potassium Injectable, potassiuua Tablets of calcium--- (KC1 to 10 KCl to 1 g/tablet) 2g 2mg 20, 6mg1 Zn 0, 1mc, 0, 94mg R b 0, 21 .g2, 1 mg Se 0,01 Mg 0 ,8 Mg K 5, 24 g 0, 524 g $4 4 4 ~4 4 4 4 4 4 '4 4 4 Mg, Zn, Rb and K are in the form of chloride.

Se is in the form of sodium selenite.

Example 2 calcium i nicactable, calcium (for I ampule of 10 mq) Ca 180 Mg mg i0, 2 mg Zn 0, 01 Mg Rb 0, 0 2mg Se 0,001 mg K 1, 95 mg Tablets of calcium 150 Mg 20, 6 mg 0, 94 mg 2, 1 mg 0, 08 Mg 195 mg The calcium is in the form of gJluconate.

Mg, Zn, Rb, K are in the form of chloride.

Se is in the form of sodium selenite.

-12- Example 3 Magnesium Mg Zn Rb Se

K

Injectable maqnesium (for 1 ampule of 10 inl) 100 Mg 0,01 mg 0, 02 mg 0, 001 mg 1, 95 mg Tablets (,fo r I of inacnsium 9/tablet) 50 mg 0, 94 mg 2, 1 mg 0, 08 mg 195 mg *00* 0.000 0 *0 0 0 0 0 0 0 0 *0 0 *00* 0q00 0 *0 0 e 0 00 0 00 0 00 0 04 00 .0 00 Zn, Rb, K are in tile form of chloride.

Mg is in the form of lactate chiovide.

Se is in the form of sodium selenite.

Example, 4 Iron Fe chloride or sulfate.

-13- Example 5 Fluorine I I t tell Example 6 Selenium Tablets of selenium (for I g/tablet) Rb Se 6 mg 0~,94 mg 2, 1 mg 0, 3 tng 19$ Mg Example 7 Chrzomium -14- REBALANCE TREATMENT The interelemental ratios must be modified accordin~g to the pathology of which the elements must be interbalanced.

By way of example, for the following pathologies, there must be used the ratios: t I tttt

I

I 4' 4 4 414 4 4 4 44 I II 4 I 4 Ii Examnple 8 (see page 14a) in mg and calcillated for a dose administrable orally

I

00 0000 *o 0~r 0 0 0 0 0 C' C C P 0 0 0I 00 00 0O 0 PATHOLOGY CA XG V. P.I Co NI C. Lr xb br 1 5. IO I 1 STANDARD 6 1.40 1.3 0.03 0.03 0.03 0.083 O.ubz u.U1 0.1. 0.16 0.06 0.00 0.001 0.0007 13 ARTICULATION BONI s.4 1.1o 1.62 0.03 0.03 0.03 0.003 0.061 u.uuJ 0.112 0.3 0.084 0.003 0.001 0.-007 13 GASTRO-INTESTINA4 10.8 1.66 1.30 0.03 0.03 0,03 0.099 0.087 0.00J 0.140 0.5?0 0.001 0.000? 13 ENDOCRINOLOGY 1.40 1.56 0.03 0.03 0.03 0.066 0.U99 10.03 U.140 0.36 0.096 0.003 0.001 0.0001 13 CARDIO-VASCULAR 0.4 0.64 1.56 0.03 0.03 0.03 0.083 0.086 0.003 0.140 0.36 0.06 0.005 0.001 0.000) 13 DERMATOLOGY 1.4 0.84 1.56 0.03 0.03 0.03 0.100 L0tJ uOOu U. 140 0.08. 0.005 0.001 0.0001 13 NEUROLOGY 2.4 1.70 1.30 0.03 0.03 0.03 0.083 o.0u4 u.01i .J.197 0.43 0.036 0.003 0.001 0.0007 13 INFECTIONS 8.4 0.84 1.62 0,03 0.03 0.03 0.133 0.111 0.OUJ U.112 0.21b 0.095 0.00? 0.001 0.0001 13 ASTHENIA- 7.2 1.40 1.80 0.03 0.03 0.03 0.116 0.081 0.UU 0.ZOO 0.36 0.072 O.004 0.001 0.0007 13 I" n I n n n n n 083 nj9 I jmI( U.22 0 36 0 072 .004 0.001 0.0001 13

MIGRAINES

I

I-

I T CIRCULATION 6 0.56 1.30 10.03 0.03 0.03 10099 10.074 -HYPERTENSION 1 0.5 1.82 0.03 0.03 0. 03 10.050 0.1.081 DIABETES 8.4 1 1L 1.04 0.03 0.03 0.03 0.083 0t.111 OBESITy 0.4 1.68 1.62 10.03 0.03 0.03 0,066 0.117 S6 0o.56 1.30 0.33 10.03 1 0.03 10.083 10.071 13 13 13 AKR(1 ROIS

ALLERGY

131 016-- iin I||II nim-lllll.-iV-M-a r* r trtr r Ir i t iii I t i r t r r r V APPLICATION TO MESOTHERAPY AND TO DERMATO-

COSMETOLOGY

Example 9 -Solution for stimulating the metabolism of adipose cells.

Mg 0.1 to 1 mg Zn 0.1 1 mg Rb 0.04 0.4 mg K 0.1 0.5 mg Cr 0.007 0.01 mg qsp amp. 2 ml Example 10 Pommade used as an adipose lissue drainer Mg 5 to 50 mg Zn 5 50 mg Rb 2 40 mg K 2 40 mg Se 1 10 mg qsp 1 g of pommade VI PHYSIOLOGICAL TESTS Example A The basic composition (Rb, K, Se, Zn, Mg) was developed and tested by studying the overall resistance on red blood cells of humans, and/or dogs, and/or cats (overall resistance test).

1. Principles of the technique used Red blood cells (RBC) are placed in the presence of sodium chloride solutions at a decreasing concentration (starting solution isotonic then hypotonic solutions in successive dilutions). This method enables the measurement for a given population of red blood cells (RBC), of the membranal resistance of the cell.

2. Qualitative determination The following elements rubidium, I rwnar~~ -16potassium,selenium, zinc, magnesium, were first tested, one after the other by using a starting isotonic solution comprising one of the elements alone or in an NaC1 medium at concentrations close to those encountered in the plasma of the species concerned.

These tests were done simultaneously with a control series only comprising sodium chloride. It was observed that there was increased resistance with each of the preceding elements.

Rb K so, I I 0900 SSe Zn 9 0 S. Mg at least one difference tube 2 or 3 difference tubes more than 3 difference tubes Conclusion The aforesaid elements possess an individual action on membranal resistance and membrane activities.

This was then followed by the same experiment associating the elements two by two and then three by three, up to the use of 5 simultaneous elements.

The results obtained in the partial associations do not exceed those of rubidium alone, a-d only the i ii ii -17mixture of the five elements enabled a superior result to be obtained.(+++) 3. Quantitative determination The concentrations of each of the elements were then modified separately to see whether the response was improved.

A slight improvement was obtained by increasing the concentration of rubidium.

On the other hand the significant modifications of the other elements had a negative effect. The interelemental proportions of the mixture were as follows t I' .4 1 I t 4 t 0 04t 0> 0 <00

B

4 ft 44 (mg 0 4. Concentration modifications The same procedure was again used by increasing, in physiological fluid, the proportion of the basic composition, as indicated in the following table.

CONCENTRATION LIMITS FOR MAN (mg/l) Element Dilution Base Concentration 1/64 1/32 1/16 1/8 1/4 1/2 1/1 x2 x3 XA X5 x6 S0,03 0,06 0,14 0,27 0,53 1,05 2,1 4,2 6,3 8,)9 10,5 12,6 K 3,13 S,26 12,5 25,7 49,2 97,5 195 390 585 783 975 1170 Se 0,001 0,002 0,005 0,01 0,02 0,04 0,08 0,16 0,24 0,32 0,AO 0,48 Zn 0,01 U,-3 0,3 .0,6 J 0,06 0,12 0,23 0,47 0,94 1,68 2,82 3,76 1,70 5,64 ~13? j2,6A j5,19 10,13 20,6 Al,? 61,8 82,4 1(13 1123 .k 32 1 2,.4 1 5,19 10,3 20.6 41,2 61's 82.4 1 3 123 i S-18- Sodium chloride and H 2 0 QSP one isotonic litre Results: The results remained similar between a dilution to one quarter and a concentration X 3.

Conclusion The cited composition has a role in the protection of the membrane which is manifested by an increased resistance of the cells to hemolysis.

Example B 1. Protocol The activation of the cellular exchanges for the basic multielemental composition was tested. Living cells (human spermatozoa) were used. The living 0 Vspermatozoa have the property of capturing vital dyes.

It was observed in the presence of said composition that the dye penetrated more rapidly into the cells.

In addition, on spermatozoa coming from the same donor, the same experiment was carried out leaving the spermatozoa 4 hours and 8 hours and it was observed o that the number of surviving spermatozoa in the o. presence of said composition was greater than that of I t the control experiment.

2. Conclusion The basic multielemental composition which comprises Rb, K, Se, Mg, Zn, favors cellular exchange.

Example C In-vivo use The adipose cell (adipocyte) is a cell with slowed down metabolism, the cell becomes clogged, drains poorly and it ia thus that cellilitis sets in of which the last stage is complete poisoning of the adipose cell which results in a fibrosis. An injectable solution whose composition is (see page 18a 18a Rb 2,1 K 195 Se 0,08 Zn 0,,94 Mg 20,6 o 1dose 2 mIi f44 r I -19was tested.

This solution was injected locally by the conventional method of mesotherapy, in 35 patients according to the following procedure local multiinjections at the rate of 1 session weekly for 6 weeks. For each patient, measurements of the adipose panicle were made by the traditional principles of measurement and also echographic checking.

Results t 4 4 4 I l 44 4 4e 0 1 4- .64 4 4 44 4 4;* a 4B t a 4 I Improvement in the appearance 34 of the skin (orange peel skin) IMPORTANT MeDIUM SMALL AEANDON Measureable diminution of the adipose panicle Conclusion The injected composition indeed caused, lically, an activation of the cellular exchanges of the adipocytes which ws manifested by a drainage of these cells and a diminution in the adipose panicle.

The composition therefore has indeed activating properties at: the level of cellular membranl exchanges.

Claims (8)

1. Composition of elements:, called multielemental composition, comprising at least the elements El, E 2 E, as follows: rubidium, pQtassium, magnesium, selenium and zinc, which constitutes the basic multielemental composition, at concentrations C 2 C n such that the values of the ratios of concentrations of each element compared to the concentration of an element of said compositions taken as a reference element, are respectively comprised between t-,e limiting values of the ratios CX 1 CX 2 Cx0 R2 R Cmt CX 1 Cx 1 in which Cx I Cx n represent the physiological concentrations of said elenents, E I En in a specific biological fluid.

2. Composition according to Claim 1, wherein at least one additional element selected from the group consisting of mineral elements, essential trace elements and cofactors, is associated with said basic multielemental composition comprising Rb, K, Mg, 7e and Zn.

3. Composition according to Claim 2, wherein the additional elements are at concentrations according to Claim 1.

4. Composition according to Claim 2, wherein the additional elements are at concentrations independent of the ratios R1, R 2 R the other elements corresponding to said basic multieiemental composition, having concentrations comprising said ratios R 1 A2 R. Composition according to Claim 1, wherein the different elements are in the form of pharmaceutically ae;eptable salts compatible with each other.

6. Process for the preparation of compositions according to Claim 1, for administration to a given species, said process comprising: determininl, for a specific biological medium of said given living species and for elements E 1 0 E 2 En in the following finite number: Rb, K, Mg, Se and Zn, the values of the respective physiological concentrations Cx 1 k a 21 CX 2 CX n of these elements in plasma; determining the values of t1 ratios Cx 1 Cx 2 Cx n RI Rn Cx1 CX 1 CX 1 of concentrations of said elements El, E 2 E. in said medium as well as the limiting values of said ratios; preparing a multielemental composition by mixing at least said elements El, E 2 E, in the following finite number: Rb, K, Mg, Se and Zn at concentrations Cl, C2 C. such that the values of the ratios of concentrations of each element of said multielemental composition compared with one of the elements of said aOao composition, taken as a reference element, are respectively comprised between the limiting values of the ratios R 1 R 2 :o Rn; and putting said composition into d form a oassimilable by said species.

7. A medicament comprising a composition according to Claim 5, wherein said medicament favours the supplementing activity of the one or more additional elements added to the basic multielemental composition.

8. A medicament comprising a composition according to Claim 5, wherein said medicament has a reequilibration activity of the one or more additional elements added to the basic multielemental composition.

9. A medicament comprising a composition according to Claim 5, wherein said m(-dicament has a stimulating action on the metabolism of adipose cells. DATED this 9th day of April 1992 CLAUDE, CHRISTOPHE By his Patent Attorneys: GRIFFITH HACK CO Fellows Institute of Patent Attorneys of Australia