AU6224790A - Proteins having anticoagulant properties - Google Patents
Proteins having anticoagulant propertiesInfo
- Publication number
- AU6224790A AU6224790A AU62247/90A AU6224790A AU6224790A AU 6224790 A AU6224790 A AU 6224790A AU 62247/90 A AU62247/90 A AU 62247/90A AU 6224790 A AU6224790 A AU 6224790A AU 6224790 A AU6224790 A AU 6224790A
- Authority
- AU
- Australia
- Prior art keywords
- proteins
- inhibitors
- factor
- anticoagulant properties
- inhibit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Proteins which specifically inhibit coagulation Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40403389A | 1989-09-07 | 1989-09-07 | |
US404033 | 1989-09-07 | ||
US49830790A | 1990-03-23 | 1990-03-23 | |
US498307 | 1990-03-23 | ||
US56516490A | 1990-08-13 | 1990-08-13 | |
US565164 | 1990-08-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6224790A true AU6224790A (en) | 1991-03-14 |
AU639257B2 AU639257B2 (en) | 1993-07-22 |
Family
ID=27410566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU62247/90A Ceased AU639257B2 (en) | 1989-09-07 | 1990-09-06 | Proteins having anticoagulant properties |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0419099B1 (en) |
JP (1) | JP3034926B2 (en) |
AT (1) | ATE133962T1 (en) |
AU (1) | AU639257B2 (en) |
CA (1) | CA2024697A1 (en) |
DE (1) | DE69025247T2 (en) |
DK (1) | DK0419099T3 (en) |
IE (1) | IE70759B1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU618364B2 (en) * | 1988-06-04 | 1991-12-19 | Hoechst Aktiengesellschaft | Amblyommin, a new active substance for anticoagulant therapy |
AU677930B2 (en) * | 1990-09-04 | 1997-05-08 | Millennium Pharmaceuticals, Inc. | Recombinant agents affecting haemophilia |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4136087A1 (en) * | 1991-10-31 | 1993-05-06 | Basf Ag, 6700 Ludwigshafen, De | NEW THROMBININHIBITOR PROTEIN FROM TICKS |
US5321010A (en) * | 1991-12-10 | 1994-06-14 | Merck & Co., Inc. | Proteins for inhibiting adhesion of platelets to collagen |
AU5670494A (en) * | 1992-12-01 | 1994-06-22 | Merck & Co., Inc. | Anticoagulant proteins |
WO1995011691A1 (en) * | 1993-10-29 | 1995-05-04 | Merck & Co., Inc. | Antithrombotic proteins |
US5863894A (en) * | 1995-06-05 | 1999-01-26 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
PL183855B1 (en) * | 1994-10-18 | 2002-07-31 | Corvas International | Inhibitors of serinic proteases and anticoagulative protecins extracted from nematodes |
US5872098A (en) * | 1995-06-05 | 1999-02-16 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
US5866542A (en) * | 1994-10-18 | 1999-02-02 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
CA2202351A1 (en) * | 1994-10-18 | 1996-04-25 | George Phillip Vlasuk | Nematode-extracted serine protease inhibitors and anticoagulant proteins |
US5866543A (en) * | 1995-06-05 | 1999-02-02 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
US5945275A (en) * | 1994-10-18 | 1999-08-31 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
US6245741B1 (en) | 1998-05-19 | 2001-06-12 | Washington University | Protein Z-dependent protease inhibitor |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
CA2623565A1 (en) | 2005-09-28 | 2007-04-05 | Biovascular, Inc. | Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation |
CN111205354B (en) * | 2020-01-22 | 2021-01-22 | 天津科技大学 | Signal peptide mutant for improving secretion of heterologous protein and construction method and application thereof |
-
1990
- 1990-09-05 CA CA002024697A patent/CA2024697A1/en not_active Abandoned
- 1990-09-06 IE IE324590A patent/IE70759B1/en not_active IP Right Cessation
- 1990-09-06 AU AU62247/90A patent/AU639257B2/en not_active Ceased
- 1990-09-07 DK DK90309834.1T patent/DK0419099T3/en active
- 1990-09-07 EP EP90309834A patent/EP0419099B1/en not_active Expired - Lifetime
- 1990-09-07 DE DE69025247T patent/DE69025247T2/en not_active Expired - Fee Related
- 1990-09-07 AT AT90309834T patent/ATE133962T1/en not_active IP Right Cessation
- 1990-09-07 JP JP2235994A patent/JP3034926B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU618364B2 (en) * | 1988-06-04 | 1991-12-19 | Hoechst Aktiengesellschaft | Amblyommin, a new active substance for anticoagulant therapy |
AU677930B2 (en) * | 1990-09-04 | 1997-05-08 | Millennium Pharmaceuticals, Inc. | Recombinant agents affecting haemophilia |
Also Published As
Publication number | Publication date |
---|---|
EP0419099B1 (en) | 1996-02-07 |
ATE133962T1 (en) | 1996-02-15 |
IE903245A1 (en) | 1991-03-13 |
CA2024697A1 (en) | 1991-03-08 |
EP0419099A1 (en) | 1991-03-27 |
DK0419099T3 (en) | 1996-03-11 |
AU639257B2 (en) | 1993-07-22 |
IE70759B1 (en) | 1996-12-30 |
DE69025247D1 (en) | 1996-03-21 |
DE69025247T2 (en) | 1996-09-12 |
JP3034926B2 (en) | 2000-04-17 |
JPH03178997A (en) | 1991-08-02 |
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