AU618435B2 - Liquid collecting tube - Google Patents
Liquid collecting tube Download PDFInfo
- Publication number
- AU618435B2 AU618435B2 AU46898/89A AU4689889A AU618435B2 AU 618435 B2 AU618435 B2 AU 618435B2 AU 46898/89 A AU46898/89 A AU 46898/89A AU 4689889 A AU4689889 A AU 4689889A AU 618435 B2 AU618435 B2 AU 618435B2
- Authority
- AU
- Australia
- Prior art keywords
- tube
- blood
- liquid
- hydrophobic
- liquid collecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007788 liquid Substances 0.000 title claims description 34
- 230000002209 hydrophobic effect Effects 0.000 claims description 50
- 210000004369 blood Anatomy 0.000 claims description 42
- 239000008280 blood Substances 0.000 claims description 42
- 239000000463 material Substances 0.000 claims description 38
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 20
- -1 polybutylene Polymers 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 10
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 230000005484 gravity Effects 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 description 12
- 239000004033 plastic Substances 0.000 description 11
- 229920003023 plastic Polymers 0.000 description 11
- 239000011521 glass Substances 0.000 description 8
- 229920001296 polysiloxane Polymers 0.000 description 8
- 210000000601 blood cell Anatomy 0.000 description 6
- 230000015271 coagulation Effects 0.000 description 6
- 238000005345 coagulation Methods 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 1
- 208000037062 Polyps Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 240000009305 Pometia pinnata Species 0.000 description 1
- 235000017284 Pometia pinnata Nutrition 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010102 injection blow moulding Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- External Artificial Organs (AREA)
Description
SMITH SHELSTON BEADLE Patent Attorneys for the Applicant TO: The Colmissioner Of Patents Our Ref. #4720 TNB:BC:WB 1;
C.M
COMPLETE
6 "W--4
SPECIFICATION
FOR OFFICE USE Application Number: Lodged: Class Int. Class Complete Specification Lodged: Accepted: Published: Priority: Related Art: TO BE COMPLETED BY APPLICANT I 4 I t 4 I tc 44 I t
I
Name of Applicant: Address of Applicant: Actual Inventor s: Address for Service: TERUMO KABUSHIKI KAISHA 44-1, Hatagaya 2-chome, Shibuya-ku, Tokyo, Japan Sakae YAMAZAKI, Masaaki KASAI and Takahito
MURASHITA
SMITH SHELSTON BEADLE 207 Riversdale Road Box 410) Hawthorn, Victoria, Australia Complete Specification for the invention entitled: LIQUID COLLECTING TUBE The following statement is a full description 4 the best method of performing it known to us: th etmto o efrigitkont s of this invention, including 4 44 4 1 4 4 4 44 4 4. 4 4 44 414 q C Psge 1 Our Ref: #4720 TNB:BC:WB a i lA- This invention relates to a liquid collecting tube for collecting liquid containing a hydrophobic component and, more particularly, to a liquid collecting tube, which can prevent attachment of the hydrophobic component to the tube inner surface.
Generally, a glazs tube or a plastic tube is used as a liquid collecting tube, for instance a blood collecting tube used for biochemical test.
Such blood collecting tubes are used for centrifugal separation of serum and clot from sampled blood. The clot is hydrophobic and liable to be Sattached to the tube inner surface. If the clot is attached to the tube inner surface, particularly an upper portion thereof, blood cells are introduced into the serum centrifugally separated and found as an upper portion of the overall liquid, thus influencing the test value and deteriorating the accuracy of test.
I Accordingly, with a conventional blood collecting 4 tube made of glass the inner surface thereof is coated with a clot attachment prevention agent for preventing the attachment of a clot. With a glass tube, glass itself has a function of promoting coagulation of blood.
To make use of this character, water-soluble silicone as disclosed in United States Patent No. 4,257,886, for instance, is coated as clot attachment prevention agent.
With such a glass tube, when blood is collected therein and in contact with water-soluble silicone, the latter is dissolved. As a result, the clean glass surface is r exposed. Therefore, although blood is partly attached bc/10/4720tkk.spo 91 9 23 2 to the glass surface, since the clean glass surface is hydrophilic, coagulation of blood is promoted. Thus, the clot is formed in a short period of time, while a tube inner surface free from attachment of clot is obtained.
With a blood collecting tube made of a plastic material, however, since the plastic material does not have any function of promoting coagulation of blood, a blood coagulation promoter is introduced into the tube to promote coagulation. Therefore, although a plastic blood collecting tube does not require use of hydrophobic silicone, since the plastic material is hydrophilic, a method of preventing attachment of clot to the tube is desired.
Even with a plastic blood collecting tube it is conceivable to coat the tube inner surface with water- S, soluble silicone for prevention of attachment of the I clot. In this case, however, if centrifugal separation is performed after the collected blood is preserved for a long time a couple of days), clot is thinly attached to the tube inner surface as the water-soluble silicone is dissolved in blood.
SUMMARY OF THE INVENTION The present invention is intended in view of the problems discussed above, and its object is to provide a liquid collecting tube, which, even made of a plastic material, is free from attachment of a hydrophobic component in the collected liquid to its inner surface and can prevent introduction of the hydrophobic xer)-' 71.' bc/10/4720tkk, spo 91 9 23 f 3 component after centrifugal separation into other components, thus permitting highly accurately test of liquid.
To attain the above object of the invention, there is provided a liquid collecting tube made of a plastic material and provided with a seal member, said tube being used for collecting a liquid composed of two or more components having different specific gravities, at least one of said components being hydrophobic, and effecting centrifugal separation with respect to said liquid, wherein a hydrophobic material being at least 06: one member of a group consisting of polypropylene glycol, polybutylene glycol and polyvinylethyl ether and .o showing fluidity in effect as hereinafter defined when 15 a predetermined centrifugal force is applied to the material is secured to the inner surface of said seal o a f'o member and at least a portion of the inner surface of f000 "0 0 the tube which would be in contact with the components 0 of said liquid other than the hydrophobic component 0 after said centrifugal separation.
By the term "showing fluidity in effect" is meant fluidity to such an extent as to prevent adsorption of an attached hydrophobic component (for instance clot) to a particular portion by shedding the hydrophobic component in flowing or by flowing together bc/10/4720tkk.spo 91 9 23
I-;
with the hydrophobic component.
The hydrophobic material shows fluidity in effect when a predetermined centrifugal force is applied to it. Therefore, the contact surface with collected liquid flows, and a hydrophobic component once attached flows along the flowing surface or flows down by being adsorbed to the flowing surface.
Thus, with the liquid collecting tube according to the invention, in which the hydrophobic material 1o is secured to a portion of its inner surface deemed to be contacted by a component other than a hydrophobic component after centrifugal separation, the hydrophobic component going to attach itself to the surface flows with the hydrophobic material and is never attached to the surface.
That is, the liquid collecting tube according to the invention, even made of a plastic material, can effectively prevent attachment of a hydrophobic component to its inner surface.
Further, with the liquid collecting tube according to the invention the hydrophobic material is securek to the tube inner surface in a state that it is not dissolved in effect in the collected liquid. Thus, even if the tube is preserved for long time, the hydrophobic material is never dissolved, and this aids the prevention of attachment of a hydrophobic component to the tube inner surface.
4,4i I? I t 44 1 4 11 4 144Ir I 1 1 S1 4 IcIIc
I
1 i I i ~T Thus, when the liquid collection tube according to the invention is used to collect blood, it is possible to effectively prevent attachment of clot to the tube inner surface or inner surface of the seal member, and there is no possibility of introduction of blood cells after centrifugal separation into serum. The accuracy of blood test thus can be improved. Particularly, where the hydrophobic material is secured to the inner surface 0o of the seal member, introduction of blood cells into serum can be prevented even when the tube is tilted.
The above effects of the invention can be obtained satisfactorily by securing the hydrophobic material in a membraneous form to the inner surface of the tube or inner surface of the seal member and setting the centrifugal force to be in a range of 500 to 1,500 G.
As the hydrophobic material, specifically at least one member of a group consisting of polypropyrene zo glycol, polybutylene glycol and polyvinylethyl ether may be suitably used.
BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a sectional view showing a reduced pressure blood collecting tube as an embodiment of the invention; ,Fig. 2 is for explainging centrifugal separation t tl 5 L i I I ji.-l j;L. i;=~ir ~lr~Y.n1--i;-r 6 with the same blood collecting tube, a state before the centrifugal separation being shown in a sectional view in Fig. and a state after the centrifugal se"paration being shown in a sectional view in Fig. and Fig. 3 shows sectional views in and of a reduced pressure blood collecting tube as a different embodiment of the invention.
DESCRIPTION OF THE PREFERRED EMBODIMENT Now, specific embodiments of the liquid collecting tube according to the invention will be described with reference to the drawings.
Fig. 1 is a sectional view showing a reduced pressure blood collecting tube as an embodiment of the invention. Referring to the Figure, reference numeral 1 designates a tube or tube member made of a plastic material. The tube 1 is opea at one end 2a and closed at the other end 2b. A hydrophobic material 3 is secured in a membranous form to the entire inner surface of the tube 1 for preventing attachment of clot as hydrophobic component. As the hydrophobic material 3 used, is one which shows fluidity and moves toward the closed end of the tube when a predetermined centrifugal force, of 500 to 1,500 G for instance, is applied to the tube 1. Specifically, bc/'tL/4720tkk.spo 91 9 23 'b 1 b the hydrophobic material 3 is suitably at least one member of a group consisting of polypropyrene glycol, polybutylene glycol and polyvinylether. The hydrophobic material 3 is secured in the membraneous form to the inner surface of the tube 1 by a commonly termed solution coating process, in which the tube is dipped in a solution of the hydrophobic material 3 and then dried.
The open end 2a of the tube 1 is sealed by a 0O seal member 4 such that a blood coagulation promoter is sealed in the tube 1 and that a predetermined reduced pressure is maintained in the tube 1. The seal member 4 comprises of a film member 4a having a gas barrier character, made of aluminum for instance, and covering the open end 2a of the tube 1 and a resealing rubber member 4b bonded to the film member 0 o 4a at a position thereof corresponding to the open end 2a of the tube 1. When collecting blood, a hollow 0 44 os piercing needle provided on aholder (not shown) is J0 introduced into the tube 1 through the re-sealing rubber member 4b and film member 4a. Since the interior of the tube 1 is ield under a reduced 0o 0 pressure, blood is introduced through the hollow piercing needle into the tube to be collected in o 25 the same.
0 o The plastic material of the tube 1 has certain transparency. Examples of the material are 0 o
A.
U'
I- p-l--rplrca~arcll-n~---- polyethylene, polypropyrene, poly(4-methylpentene), polystyrene, polycarbonate, polymethyl methacylate, polyethylene telephthalate, nylon and acylonitrile polymers. It is possible to seal a coagulation-resistant agent, a serum separation agent, etc. in the tube 1.
In this embodiment of the reduced pressure blood collecting tube, the hydrophobic substance 3 is found in a membraneous form on the entire inner surface i' of the tube 1, by holding the tube upright as shown in Fig. 2(a) after collecting blood, blood 7 immediately shedded by an upper portion of the tube inner surface where blood 7 is not deemed to be in contact with, and also no clot is attached to a portion of the tube inner surface, with which blood 7 is deemed to be in contact. When centrifugal separation is performed with a centrifugal force of 500 to 1,500 G after preserving the collected blood for long time, serum 8 and clot 9 are separated as respective upper tO and lower portions as shown in Fig. At this time, clot 9 attached to an upper portion of the inner surface of the tube 1 flows together with the hydrophobic material 3 toward the closed end 2b of the tube. That is there is no possibility of attachment of clot 9 to the tube inner surface upper portion, and thus there is no possibility for blood cells to be introduced into serum and have adverse 8
I,
_I ti effects on the test.
While a preferred embodiment of the invention has been described above, the embodiment is by no means limitative and can be variously modified without departing from the scope of the invention. For example, while in the above embodiment the hydrophobic material 3 is secured to the entire inner surface of the tube 1, it is only necessary to secure the hydrophobic material 3 to a portion of the tube inner surface, with which serum B separated by centrifugal separation is in contact. After centrifugal separation, clot 9 is liable to be attached to the inner surface of the seal member 4, and also serum 8 is liable to be in contact with clot 9 when the tube is tilted. For these reasons, a membrane of hydrophobic material 3 is suitably formed not only on the inner surface of a blood collecting tube 1 but also on the inner surface of the seal member 4 as shown in Figs. 3(a) and 3(b) of a second embodiment X.0 of the present invention in which reference numerals of parts shown therein are identical with those corresponding to the first embodiment.
Fig. shows the tube 1 held upright in a state that blood is not collected into the tube yet.
Fig. 3(b) shows the tube 1 in a state that the blood is collected therein and serum 8 and clot 9 are separated by centrifugal separation. When the tube 9 t t 1 is tilted as shown in Fig. then clot 9 is liable to be attached to the miner surface of the seal member 4, but can easily flow down together with the hydrophobic material 3 which is formed on the inner surface of the seal member 4 upon centrifugal separation. Thus, there is also no possibility of attachment of clot 9 to the inner surface of the seal member 4.
It is possible to form a mambrane of the hydrophobic material 3 only on the inner surface of the sealed member 4.
Further, while in the above embodiment the hydrophobic material 3 is coated in the membranous form cn thb inner surface of the tube 1, it its also rossible to add the hydrophobic material 3 to the material of the tube 1 before molding the tute by 4 44 the ordinary injection molding process or blow molding i t process, whereby the hydrophobic material 3 is dispersed on the surface of the tube 1. In this case, S o0 the same effects as described above can be obtained although the transparency of the tu')e 1 is slightly sacrificed. Further, it is possible to employ this method in combination of the coating method described before.
25 Further, while the above embodiment has concerned t with blood as collected liquid and prevention of introduction of blood cells after centrifugal 10 mmu-l~ -l i separation into serum, the invention is generally applicable to a liquid composed of two or more components having different specific gravities and including a hydrophobic component and prevention of introduction of the hydrophobic component after separation intc. other components.
To confirm the effects of the invention, the inventor conducted the following experiment.
(Experiment) A blood collecting tube made of a polyethylene telephthalate resin (manufactured by Mitsui Pet Co., Ltd. and available under a trade name "J025:B010=7:3") was dipped in an ethanol solution containing 0.2 of polyp.opyrene glycol and then dried to secure a membrane of polypropyrene glycol to the entire tube o a inner surface Then, a coagulation promotion film 0 0 "o (polyethylene telephthalate film coated with glass 0 0 *o o particles and polyvinyl pyrolydon (PVP) in a ratio v of 3 1) was introduced into the tube, and the tube 10 was then sealed with a seal member having a gas barrier character.
As blood cllection experiment, blood was collected from five persons using five such reduced Q 9e 04 pressure blood collecting tubes for each person.
°2Z5 After blood collection, each tube was perserved at 4*C for 24 hours, and then centrifugal separation 1 was performed for 10 minutes with 1,200 G. Then, 11 1_1~ 9~^1LI the status of attachment of clot to the tube inner surface was observed.
Further, similar blood collection experiment was conducted using a polyethylene telephthalate tube with water-soluble silicone secured thereto by dipping the tube in an ethanol solution containing 0.2 of water-soluble silicon (manufactured by Tore Silicone Co., Ltd. and available under a trade name "SH3771") and then drying the tube.
1o A satisfactory result could be obtained that with the tube with the polypropyrene glycol membrane less clot was attached to the tube inner surface compared to the tube with the water-soluble silicone membrane.
As has been described in the foregoing, with the liquid collecting tube according to the invention a hydrophobic component once attached to the tube inner surface flows drwn along the fluidized surface of the hydrophobic substance or while being adsorbed thereto. Particularly, where the liquid is blood, attachment of clot to the inner surface of the tube and inner surface of the seal member can be prevented and also introduction of blood cells into serum can be prevented, thus eliminating adverse effects on a I the blood tost and improving the accuracy of test.
The claims form part of the disclosure of this specification.
12 12 i
Claims (4)
1. A liquid collecting tut made of a plas'tic material and provided with a seal member, said tube being used for collecting a liquid composed of two or more components having different specific gravities, at least one of said components being hydrophobic, and effecting centrifugal separation with respect to said liquid, wherein a hydrophobic material being at least one member of a group consisting of polypropyrene glycol, polybutylene glycol and polyvinylethyl ether and showing fluidity in effect as hereinbefore defined when a predetermined centrifugal force is applied to the material is secured to the inner surface of said seal member and at least a portion of the inner surface of the tube which would be in contact with the components of said liquid other than the hydrophobic component after said centrifugal separation.
2. The liquid collecting tube according to claim 1, wherein se&.d hydrophobic material is secured in a membranous form to the respective inner surfaces of said tube member and said seal member.
3. The liquid collecting tube ac'cording to claim 2, wherein said predetermined centrifugal force is in a range of 500 to 1,500 G.
4. The liquid collecting tube according to any one of the preceding claims, wherein the liquid is blood, and said hydrophobic component is clot in the blood. A liquid collecting tube substantially as bc/10/4720tlk.pe 91 9 23 k 0/ exposed. Therefore, although blood is partly attached bc/1O/4720tkk. spe 91 9 23 Or4 14 hereinbefore described with reference to the accompanying drawings. DATED this September 23, 1991 CARTER SMITH BEADLE Fellows Institute of Patent Attorneys of Australia Patent Attorneys for the Applicant: TERUMO KABUSHIKI KAISHA 1hc/1O/4?Z0tkk. Apo 91 9 23
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31775688 | 1988-12-16 | ||
| JP63-317756 | 1988-12-16 | ||
| JP1-319834 | 1989-12-08 | ||
| JP1319834A JP2819325B2 (en) | 1988-12-16 | 1989-12-08 | Sample tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU4689889A AU4689889A (en) | 1990-07-19 |
| AU618435B2 true AU618435B2 (en) | 1991-12-19 |
Family
ID=26569135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU46898/89A Expired AU618435B2 (en) | 1988-12-16 | 1989-12-15 | Liquid collecting tube |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2819325B2 (en) |
| AU (1) | AU618435B2 (en) |
| BE (1) | BE1004836A3 (en) |
| FR (1) | FR2640753B1 (en) |
| IT (1) | IT1237910B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040059255A1 (en) * | 2002-09-23 | 2004-03-25 | Dimitrios Manoussakis | High bias gel tube and process for making tube |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4257886A (en) * | 1979-01-18 | 1981-03-24 | Becton, Dickinson And Company | Apparatus for the separation of blood components |
| AU539196B2 (en) * | 1979-09-11 | 1984-09-13 | Terumo Corp. | Blood serum-separating agent |
| AU559940B2 (en) * | 1979-09-11 | 1987-03-26 | Terumo Corp. | Blood collecting tube |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920549A (en) * | 1974-03-18 | 1975-11-18 | Corning Glass Works | Method and apparatus for multiphase fluid collection and separation |
| US4308232A (en) * | 1979-07-09 | 1981-12-29 | Sherwood Medical Industries Inc. | Anticoagulant stopper coating |
| JPS59221666A (en) * | 1983-05-31 | 1984-12-13 | Terumo Corp | Blood separating tube |
| FR2555074B3 (en) * | 1983-11-18 | 1986-07-18 | Ohayon Hanania | DEVICE FOR SEPARATING BLOOD AND OBTAINING SERUM |
-
1989
- 1989-12-08 JP JP1319834A patent/JP2819325B2/en not_active Expired - Fee Related
- 1989-12-14 FR FR8916574A patent/FR2640753B1/en not_active Expired - Lifetime
- 1989-12-15 IT IT02270389A patent/IT1237910B/en active IP Right Grant
- 1989-12-15 AU AU46898/89A patent/AU618435B2/en not_active Expired
- 1989-12-15 BE BE8901339A patent/BE1004836A3/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4257886A (en) * | 1979-01-18 | 1981-03-24 | Becton, Dickinson And Company | Apparatus for the separation of blood components |
| AU539196B2 (en) * | 1979-09-11 | 1984-09-13 | Terumo Corp. | Blood serum-separating agent |
| AU559940B2 (en) * | 1979-09-11 | 1987-03-26 | Terumo Corp. | Blood collecting tube |
Also Published As
| Publication number | Publication date |
|---|---|
| BE1004836A3 (en) | 1993-02-09 |
| JPH02277460A (en) | 1990-11-14 |
| IT1237910B (en) | 1993-06-18 |
| FR2640753A1 (en) | 1990-06-22 |
| JP2819325B2 (en) | 1998-10-30 |
| AU4689889A (en) | 1990-07-19 |
| IT8922703A0 (en) | 1989-12-15 |
| FR2640753B1 (en) | 1993-07-30 |
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