AU588543B2 - Novel carbacyclins, processes for preparation and medicinal use thereof - Google Patents

Novel carbacyclins, processes for preparation and medicinal use thereof

Info

Publication number
AU588543B2
AU588543B2 AU46767/85A AU4676785A AU588543B2 AU 588543 B2 AU588543 B2 AU 588543B2 AU 46767/85 A AU46767/85 A AU 46767/85A AU 4676785 A AU4676785 A AU 4676785A AU 588543 B2 AU588543 B2 AU 588543B2
Authority
AU
Australia
Prior art keywords
rest
atoms
hydrogen
carbon
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU46767/85A
Other versions
AU4676785A (en
Inventor
Bob Nieuweboer
Claus-Steffen Sturzebecher
Helmut Vorbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU4676785A publication Critical patent/AU4676785A/en
Application granted granted Critical
Publication of AU588543B2 publication Critical patent/AU588543B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/62—Unsaturated compounds containing ether groups, groups, groups, or groups containing rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Carbacycline derivatives of formula (I) are disclosed, wherein: n is 1 or 3, R1? is the rest having the formula (II), the rest having the formula (III), -COCH3?, the rest COOR2? wherein R2? is hydrogen or alkyl with 1 to 10 atoms of carbon optionally substituted by halogen, phenyl, C1?-C4?-alkoxy or C1?-C4?-dialkyl-amino; cycloalkyl, aryl or heterocyclic rest; or the rest CONHR3? wherein R3? is hydrogen or a rest alkanoyl sulfonyl or alkane sulfonyl with 1 to 10 atoms of carbon. R9? is an alkyl group with 1 to 10 atoms of carbon or the group -C=C- (CH2?)m?-R6? wherein m is 1 to 16 and R6? is hydrogen, hydroxy, amino or trimethylsilyl, X is an oxygen atom or when R9? is an alkyl group with 5 to 10 atoms of carbon, a methylene group and Y is hydrogen or fluorine. Also disclosed are a preparation process thereof and drugs containing them.
AU46767/85A 1984-07-27 1985-07-18 Novel carbacyclins, processes for preparation and medicinal use thereof Ceased AU588543B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3428266 1984-07-27
DE3428266A DE3428266A1 (en) 1984-07-27 1984-07-27 NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
AU4676785A AU4676785A (en) 1986-02-25
AU588543B2 true AU588543B2 (en) 1989-09-21

Family

ID=6242048

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46767/85A Ceased AU588543B2 (en) 1984-07-27 1985-07-18 Novel carbacyclins, processes for preparation and medicinal use thereof

Country Status (11)

Country Link
EP (1) EP0190233B1 (en)
JP (1) JPS61502823A (en)
AT (1) ATE83232T1 (en)
AU (1) AU588543B2 (en)
CA (1) CA1275093A (en)
DE (2) DE3428266A1 (en)
DK (1) DK119886A (en)
ES (1) ES8606841A1 (en)
GR (1) GR851843B (en)
HU (1) HU196175B (en)
WO (1) WO1986000895A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3542745A1 (en) * 1985-11-29 1987-08-06 Schering Ag NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4735966A (en) * 1986-08-25 1988-04-05 Syntex (U.S.A.) Inc. Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties
US5374654A (en) * 1987-07-24 1994-12-20 Schering Aktiengesellschaft 9-substituted carbacyclin derivatives, processes for their preparation, and their use as medicinal agents
DE3725031A1 (en) * 1987-07-24 1989-02-02 Schering Ag NEW 9-SUBSTITUTED CARBACYCLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DE4134156A1 (en) * 1991-10-11 1993-04-15 Schering Ag 9-SUBSTITUTED BICYCLO (3.3.0) OCTANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL USE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004021A1 (en) * 1982-05-06 1983-11-24 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. 2,3,4-trinor-1,5-inter-m-phenylene-prostacycline-i2 analogues, process for the preparation thereof and pharmaceutical compositions containing the same
AU2372684A (en) * 1983-02-01 1984-08-02 Sumitomo Chemical Company, Limited Bicyclooctane derivatives
AU3973485A (en) * 1984-03-08 1985-09-12 Schering Aktiengesellschaft Carbaprostaglandin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
DE2845770A1 (en) * 1978-10-19 1980-04-30 Schering Ag NEW PROSTACYCLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3048906A1 (en) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4533749A (en) * 1982-02-16 1985-08-06 The Upjohn Company 9-Substituted carbacyclin analogs
US4487961A (en) * 1982-02-16 1984-12-11 The Upjohn Company 9-Substituted carbacyclin analogs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004021A1 (en) * 1982-05-06 1983-11-24 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. 2,3,4-trinor-1,5-inter-m-phenylene-prostacycline-i2 analogues, process for the preparation thereof and pharmaceutical compositions containing the same
AU2372684A (en) * 1983-02-01 1984-08-02 Sumitomo Chemical Company, Limited Bicyclooctane derivatives
AU3973485A (en) * 1984-03-08 1985-09-12 Schering Aktiengesellschaft Carbaprostaglandin derivatives

Also Published As

Publication number Publication date
GR851843B (en) 1985-11-26
AU4676785A (en) 1986-02-25
JPS61502823A (en) 1986-12-04
ES8606841A1 (en) 1986-05-16
CA1275093A (en) 1990-10-09
DE3586891D1 (en) 1993-01-21
ES545617A0 (en) 1986-05-16
EP0190233B1 (en) 1992-12-09
ATE83232T1 (en) 1992-12-15
WO1986000895A1 (en) 1986-02-13
DK119886D0 (en) 1986-03-14
DK119886A (en) 1986-03-14
HUT39158A (en) 1986-08-28
HU196175B (en) 1988-10-28
DE3428266A1 (en) 1986-01-30
EP0190233A1 (en) 1986-08-13

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