AU5847890A - Process for producing pressed, moulded, delayed release dose units and dose units thus produced - Google Patents

Process for producing pressed, moulded, delayed release dose units and dose units thus produced

Info

Publication number
AU5847890A
AU5847890A AU58478/90A AU5847890A AU5847890A AU 5847890 A AU5847890 A AU 5847890A AU 58478/90 A AU58478/90 A AU 58478/90A AU 5847890 A AU5847890 A AU 5847890A AU 5847890 A AU5847890 A AU 5847890A
Authority
AU
Australia
Prior art keywords
release
unit
dose units
dosage forms
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU58478/90A
Other versions
AU651316B2 (en
AU651316C (en
Inventor
Klaus Budde
Fritz Demmer
Berthold Stemmle
Alexander Wirl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Group PTC ehf
Original Assignee
Actavis Group PTC ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actavis Group PTC ehf filed Critical Actavis Group PTC ehf
Publication of AU5847890A publication Critical patent/AU5847890A/en
Publication of AU651316B2 publication Critical patent/AU651316B2/en
Application granted granted Critical
Publication of AU651316C publication Critical patent/AU651316C/en
Assigned to ACTAVIS GROUP PTC EHF. reassignment ACTAVIS GROUP PTC EHF. Alteration of Name(s) in Register under S187 Assignors: BOEHRINGER MANNHEIM GMBH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Casting Or Compression Moulding Of Plastics Or The Like (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)

Abstract

Process for the preparation of shaped, compressed controlled-release unit-dosage forms from a therapeutic active substance exhibiting a self-retarding release that depends on the magnitude of the force used for the compression. The process gives unit-dosage forms for which the release of the active substance is highly uniform, reproducibly identical and largely linear. To achieve this, the active substance and an additive charge that inhibits or compensates for the self-retardation of its release are processed into particles in the first stage of production, so that the preliminary compressed objects made from these particles without any further additives exhibit a rapid release (in comparison with the required controlled release) over the range of the force of compression envisaged for the production of the unit-dosage form in question, after which the particles are compressed in the second stage of production with a release-retarding agent to obtain the unit-dosage forms. The invention also relates to the unit-dosage forms thus obtained.
AU58478/90A 1990-07-02 Process for producing pressed, moulded, delayed release dose units and dose units thus produced Expired AU651316C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/DE1990/000498 WO1992000064A1 (en) 1990-07-02 1990-07-02 Process for producing pressed, moulded, delayed release dose units and dose units thus produced
CA002085231A CA2085231C (en) 1990-07-02 1990-07-02 Process for the preparation of shaped, compressed controlled-release unit-dosage forms, and the compressed unit-dosage forms thus obtained
US95570592A 1992-12-18 1992-12-18

Publications (3)

Publication Number Publication Date
AU5847890A true AU5847890A (en) 1992-01-23
AU651316B2 AU651316B2 (en) 1994-07-21
AU651316C AU651316C (en) 1995-01-27

Family

ID=

Also Published As

Publication number Publication date
CA2085231C (en) 1997-12-30
HU9204151D0 (en) 1993-04-28
IL98632A (en) 1996-12-05
ES2056470T3 (en) 1994-10-01
HU219341B (en) 2001-03-28
EP0537139B1 (en) 1994-05-18
NZ238702A (en) 1992-10-28
EP0537139A1 (en) 1993-04-21
WO1992000064A1 (en) 1992-01-09
FI103179B1 (en) 1999-05-14
ZA915047B (en) 1992-04-29
AU651316B2 (en) 1994-07-21
DE59005781D1 (en) 1994-06-23
CA2085231A1 (en) 1992-01-03
ATE105710T1 (en) 1994-06-15
FI103179B (en) 1999-05-14
US5840330A (en) 1998-11-24
DK0537139T3 (en) 1994-08-22
HUT74904A (en) 1997-03-28
FI925984A (en) 1992-12-31
FI925984A0 (en) 1992-12-31

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