AU574604B2 - Optically active dihydro pyridine dicarboxylate derivative - Google Patents

Optically active dihydro pyridine dicarboxylate derivative

Info

Publication number
AU574604B2
AU574604B2 AU70525/87A AU7052587A AU574604B2 AU 574604 B2 AU574604 B2 AU 574604B2 AU 70525/87 A AU70525/87 A AU 70525/87A AU 7052587 A AU7052587 A AU 7052587A AU 574604 B2 AU574604 B2 AU 574604B2
Authority
AU
Australia
Prior art keywords
optically active
pyridine dicarboxylate
dihydro pyridine
dicarboxylate derivative
active dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU70525/87A
Other versions
AU7052587A (en
Inventor
Hermann Amschler
Manfrid Eltze
Dieter Flockerzi
Kurt Klemm
Bernhard Kohl
Norbert Kolassa
Karl Sanders
Christian Schudt
Wolf-Rudiger Ulrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of AU7052587A publication Critical patent/AU7052587A/en
Application granted granted Critical
Publication of AU574604B2 publication Critical patent/AU574604B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU70525/87A 1986-03-27 1987-03-23 Optically active dihydro pyridine dicarboxylate derivative Ceased AU574604B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1263/86 1986-03-27
CH126386 1986-03-27

Publications (2)

Publication Number Publication Date
AU7052587A AU7052587A (en) 1987-12-10
AU574604B2 true AU574604B2 (en) 1988-07-07

Family

ID=4206306

Family Applications (1)

Application Number Title Priority Date Filing Date
AU70525/87A Ceased AU574604B2 (en) 1986-03-27 1987-03-23 Optically active dihydro pyridine dicarboxylate derivative

Country Status (12)

Country Link
EP (1) EP0240828A1 (en)
JP (1) JPS62270528A (en)
KR (1) KR870008872A (en)
CN (1) CN87102402A (en)
AU (1) AU574604B2 (en)
DK (1) DK142287A (en)
FI (1) FI871327A (en)
HU (1) HU196791B (en)
NO (1) NO871284L (en)
NZ (1) NZ219779A (en)
PT (1) PT84566B (en)
ZA (1) ZA872189B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU638205B2 (en) * 1988-02-19 1993-06-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3883627D1 (en) * 1987-03-27 1993-10-07 Byk Gulden Lomberg Chem Fab 1,4-dihydropyridine enantiomers.
DE4125271A1 (en) * 1991-07-31 1993-02-11 Bayer Ag NEW N-ALKYLATED 1,4-DIHYDROPYRIDINDICARBONIC ACID ESTERS
US6015819A (en) 1992-11-13 2000-01-18 Synaptic Pharmaceutical Corporation Use of alpha-1C specific compounds to treat benign prostatic hyperplasia
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4794885A (en) * 1984-09-28 1986-04-10 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydro-3 (4,4-diphenylpiperid-1-yl alkoxy carbonyl) -pyridine derivatives
AU6984987A (en) * 1986-03-12 1987-09-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 1,4-dihydropyridine ester derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935451A1 (en) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
US4603135A (en) * 1983-10-17 1986-07-29 Takeda Chemical Industries, Ltd. Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4794885A (en) * 1984-09-28 1986-04-10 Byk Gulden Lomberg Chemische Fabrik Gmbh 1,4-dihydro-3 (4,4-diphenylpiperid-1-yl alkoxy carbonyl) -pyridine derivatives
AU6984987A (en) * 1986-03-12 1987-09-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 1,4-dihydropyridine ester derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU638205B2 (en) * 1988-02-19 1993-06-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Optically pure r-(-)-niguldipine and its derivatives for treating tumorous diseases

Also Published As

Publication number Publication date
HUT43588A (en) 1987-11-30
NZ219779A (en) 1990-03-27
HU196791B (en) 1989-01-30
PT84566B (en) 1989-11-30
NO871284D0 (en) 1987-03-26
DK142287A (en) 1987-09-28
AU7052587A (en) 1987-12-10
FI871327A (en) 1987-09-28
CN87102402A (en) 1987-10-07
FI871327A0 (en) 1987-03-26
JPS62270528A (en) 1987-11-24
ZA872189B (en) 1987-11-25
NO871284L (en) 1987-09-28
KR870008872A (en) 1987-10-21
PT84566A (en) 1987-04-01
EP0240828A1 (en) 1987-10-14
DK142287D0 (en) 1987-03-19

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