AU565568B2 - 23, 23-difluoro-1 , 25-dihydroxy-vitamin d3 - Google Patents

23, 23-difluoro-1 , 25-dihydroxy-vitamin d3

Info

Publication number
AU565568B2
AU565568B2 AU30661/84A AU3066184A AU565568B2 AU 565568 B2 AU565568 B2 AU 565568B2 AU 30661/84 A AU30661/84 A AU 30661/84A AU 3066184 A AU3066184 A AU 3066184A AU 565568 B2 AU565568 B2 AU 565568B2
Authority
AU
Australia
Prior art keywords
vitamin
ether
difluoro
thp
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU30661/84A
Other languages
English (en)
Other versions
AU3066184A (en
Inventor
Hector F. Deluca
N. Ikekawa
Y. Kobayashi
Y. Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU3066184A publication Critical patent/AU3066184A/en
Application granted granted Critical
Publication of AU565568B2 publication Critical patent/AU565568B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU30661/84A 1983-08-18 1984-06-13 23, 23-difluoro-1 , 25-dihydroxy-vitamin d3 Ceased AU565568B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/524,268 US4502991A (en) 1983-08-18 1983-08-18 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US524268 1990-05-15

Publications (2)

Publication Number Publication Date
AU3066184A AU3066184A (en) 1985-03-12
AU565568B2 true AU565568B2 (en) 1987-09-17

Family

ID=24088490

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30661/84A Ceased AU565568B2 (en) 1983-08-18 1984-06-13 23, 23-difluoro-1 , 25-dihydroxy-vitamin d3

Country Status (9)

Country Link
US (2) US4502991A (enExample)
JP (1) JPS60502153A (enExample)
AU (1) AU565568B2 (enExample)
BE (1) BE900385A (enExample)
CH (1) CH671761A5 (enExample)
DK (1) DK172485A (enExample)
IL (1) IL72155A (enExample)
NL (1) NL8420179A (enExample)
WO (1) WO1985000819A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573367B2 (en) * 1984-07-26 1988-06-02 Rippelton N.V. Combustion of solid fuels

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687423A (en) * 1985-06-07 1987-08-18 Ivac Corporation Electrochemically-driven pulsatile drug dispenser
WO1987003282A1 (fr) * 1985-11-21 1987-06-04 Taisho Pharmaceutical Co., Ltd. Derive de la vitamine d3
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
FR2607815B1 (fr) * 1986-12-05 1988-12-30 Roussel Uclaf Nouveaux produits steroides comportant, en position 23, un radical cetonique, leur procede de preparation, leur application a la preparation de produits de la serie des 20-cetopregnanes et des intermediaires de cette association
US4902278A (en) * 1987-02-18 1990-02-20 Ivac Corporation Fluid delivery micropump
US4892821A (en) * 1987-07-08 1990-01-09 Taisho Pharmaceutical Co., Ltd. Method for preparing vitamin D compounds
GB8816505D0 (en) * 1988-07-12 1988-08-17 Leo Pharm Prod Ltd Novel treatment
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
TW584627B (en) 1996-07-01 2004-04-21 Chugai Pharmaceutical Co Ltd The method for purifying vitamin D derivatives and its crystalline products
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
US6875539B2 (en) * 2002-01-18 2005-04-05 Heiner Ophardt Combination liquid dispenser and electrochemical cell
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
JP2011508743A (ja) * 2007-12-28 2011-03-17 ウィスコンシン アラムナイ リサーチ ファンデーション （２０ｓ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4421690A (en) * 1982-05-17 1983-12-20 Hoffmann-La Roche Inc. Process for the preparation of 24,24-difluoro-1α,25-dihydroxy vitamin D3 and intermediates obtained therefrom

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573367B2 (en) * 1984-07-26 1988-06-02 Rippelton N.V. Combustion of solid fuels

Also Published As

Publication number Publication date
IL72155A (en) 1987-09-16
BE900385A (fr) 1984-12-17
WO1985000819A1 (en) 1985-02-28
US4502991A (en) 1985-03-05
IL72155A0 (en) 1984-10-31
AU3066184A (en) 1985-03-12
NL8420179A (nl) 1985-07-01
CH671761A5 (enExample) 1989-09-29
DK172485D0 (da) 1985-04-17
JPS60502153A (ja) 1985-12-12
US4552698A (en) 1985-11-12
DK172485A (da) 1985-06-18

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