AU557485B2 - Chromatographic-based rapid tests - Google Patents

Chromatographic-based rapid tests

Info

Publication number
AU557485B2
AU557485B2 AU35818/84A AU3581884A AU557485B2 AU 557485 B2 AU557485 B2 AU 557485B2 AU 35818/84 A AU35818/84 A AU 35818/84A AU 3581884 A AU3581884 A AU 3581884A AU 557485 B2 AU557485 B2 AU 557485B2
Authority
AU
Australia
Prior art keywords
antibodies
immunochemical
molecular sieve
penetration
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35818/84A
Other versions
AU3581884A (en
Inventor
Helmut Freitag
Anselm Rothe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU3581884A publication Critical patent/AU3581884A/en
Application granted granted Critical
Publication of AU557485B2 publication Critical patent/AU557485B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to devices for carrying out quick immunochemical tests and to methods for the immunochemical determination of suitable proteins using this device. The device consists of a layer which has capillary activity and consists of a dry, porous, non-swelling, particulate material with molecular sieve properties, the pore size of the molecular sieve allowing penetration of the soluble antibodies used for the immunochemical detection of the antigens but allowing little or no penetration of the soluble immune complexes formed from antigen and antibodies. The layers with capillary activity are preferably contained in a glass or plastic capillary column or are attached to an inert support material. In the method according to the invention, a substrate sample is loaded onto one end of the device, and the immune complex which is formed where appropriate is separated from the antibodies by chromatography using a solvent and is detected.
AU35818/84A 1983-11-25 1984-11-23 Chromatographic-based rapid tests Ceased AU557485B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3342627 1983-11-25
DE19833342627 DE3342627A1 (en) 1983-11-25 1983-11-25 IMMUNCHEMICAL QUICK TEST

Publications (2)

Publication Number Publication Date
AU3581884A AU3581884A (en) 1985-05-30
AU557485B2 true AU557485B2 (en) 1986-12-24

Family

ID=6215226

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35818/84A Ceased AU557485B2 (en) 1983-11-25 1984-11-23 Chromatographic-based rapid tests

Country Status (10)

Country Link
EP (1) EP0143412B1 (en)
JP (1) JPS60190864A (en)
AT (1) ATE72704T1 (en)
AU (1) AU557485B2 (en)
CA (1) CA1248446A (en)
CS (1) CS262653B2 (en)
DD (1) DD234495A5 (en)
DE (2) DE3342627A1 (en)
ES (1) ES8600813A1 (en)
FI (1) FI78786C (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4837145A (en) * 1986-06-09 1989-06-06 Liotta Lance A Layered immunoassay using antibodies bound to transport particles to determine the presence of an antigen
JPH0734015B2 (en) * 1988-04-25 1995-04-12 和光純薬工業株式会社 New method for measuring trace components
GB9310468D0 (en) * 1993-05-20 1993-07-07 Oxford Glycosystems Ltd Sugar complexes
DE19601346A1 (en) * 1996-01-16 1997-07-17 Bernd Dr Pevec Analysis method based on immune response
PT797097E (en) * 1996-03-18 2002-06-28 Stiftung Fur Diagnostische For IMMUNOLOGICAL TESTING OF PARTICLES WITH COMPACT MATRIX
NL1006680C2 (en) * 1997-03-04 1998-09-07 Alexander Adrianus Moen Method for detecting the presence of an immunologically reactive molecule in a sample.
GB0008124D0 (en) * 2000-04-03 2000-05-24 Genosis Ltd Capture assay
FR2832321B1 (en) * 2001-11-21 2004-01-09 Adiatec Sa SIZE EXCLUSION FILTRATION DEVICE, MANUFACTURING METHOD THEREOF, AND RESULTING FILTRATION METHOD

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51354A (en) * 1977-01-28 1979-07-25 Ames Yissum Ltd Assay method for the quantitative determination of a hapten in aqueous solution
US4301139A (en) * 1979-06-21 1981-11-17 Ames-Yissum Ltd. Multilayer column chromatography specific binding assay method, test device and test kit
EP0073593A1 (en) * 1981-09-01 1983-03-09 E.I. Du Pont De Nemours And Company Size-exclusion heterogeneous immunoassay
DE3217032C2 (en) * 1982-03-26 1985-04-25 Armin Dipl.-Chem. Dr. rer.nat. 5300 Bonn Gilak Simplified separation procedure for immunological determinations and dry chromatographic column for carrying out the procedure

Also Published As

Publication number Publication date
DE3342627A1 (en) 1985-06-05
JPS60190864A (en) 1985-09-28
ATE72704T1 (en) 1992-03-15
AU3581884A (en) 1985-05-30
FI78786B (en) 1989-05-31
CS896584A2 (en) 1988-08-16
DD234495A5 (en) 1986-04-02
EP0143412A2 (en) 1985-06-05
EP0143412A3 (en) 1988-03-30
ES537910A0 (en) 1985-11-01
ES8600813A1 (en) 1985-11-01
EP0143412B1 (en) 1992-02-19
FI844607A0 (en) 1984-11-23
CS262653B2 (en) 1989-03-14
CA1248446A (en) 1989-01-10
FI78786C (en) 1989-09-11
FI844607L (en) 1985-05-26
DE3485513D1 (en) 1992-03-26

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