AU5552794A - Hepatic model - Google Patents

Hepatic model

Info

Publication number
AU5552794A
AU5552794A AU55527/94A AU5552794A AU5552794A AU 5552794 A AU5552794 A AU 5552794A AU 55527/94 A AU55527/94 A AU 55527/94A AU 5552794 A AU5552794 A AU 5552794A AU 5552794 A AU5552794 A AU 5552794A
Authority
AU
Australia
Prior art keywords
hepatic model
hepatic
model
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU55527/94A
Inventor
Jerome Hochman
Edward Lecluyse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU5552794A publication Critical patent/AU5552794A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU55527/94A 1992-11-25 1993-11-12 Hepatic model Abandoned AU5552794A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98196492A 1992-11-25 1992-11-25
US981964 1992-11-25
PCT/US1993/010874 WO1994012662A1 (en) 1992-11-25 1993-11-12 Hepatic model

Publications (1)

Publication Number Publication Date
AU5552794A true AU5552794A (en) 1994-06-22

Family

ID=25528763

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55527/94A Abandoned AU5552794A (en) 1992-11-25 1993-11-12 Hepatic model

Country Status (5)

Country Link
EP (1) EP0673433A1 (en)
JP (1) JPH08503610A (en)
AU (1) AU5552794A (en)
CA (1) CA2154701A1 (en)
WO (1) WO1994012662A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01009213A (en) 1999-03-17 2002-10-11 Univ North Carolina Method of screening candidate compounds for susceptibility to biliary excretion.
US7601494B2 (en) 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
WO2001059062A2 (en) * 2000-02-11 2001-08-16 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for obtaining in vitro polarized hepatoma cell lines
US7034553B2 (en) 2003-12-05 2006-04-25 Prodont, Inc. Direct resistance measurement corrosion probe
JP6087264B2 (en) 2013-11-29 2017-03-01 株式会社日立ハイテクノロジーズ Component analyzer, medicinal effect analyzer, and analysis method
JP6644786B2 (en) * 2014-08-22 2020-02-12 ビオプレディク アンテルナシオナルＢｉｏｐｒｅｄｉｃ Ｉｎｔｅｒｎａｔｉｏｎａｌ Mechanical modification of bile duct activity and modulation of Rho kinase myosin II pathway and junction permeability, methods for its detection and use of its derivatives
JP2017527283A (en) * 2014-09-02 2017-09-21 ヒューレル コーポレーション In vitro bile excretion assay
JP6758026B2 (en) 2015-04-17 2020-09-23 株式会社日立ハイテク Component analyzer, drug component analyzer, component analysis method and drug component analysis method
WO2017085119A1 (en) * 2015-11-16 2017-05-26 Insphero Ag Method and assay for the assessment of a cholestatic risk of a compound
KR101864410B1 (en) * 2016-01-21 2018-06-05 한국화학연구원 Three dimensional hepatocyte culturing unit, evaluating system for hepatotoxicity and method using the same
JP6756493B2 (en) * 2016-02-29 2020-09-16 米満　吉和 High-performance hepatocytes and their utilization
CN113396225A (en) 2019-02-26 2021-09-14 株式会社日立高新技术 Dynamic analysis method of intracellular compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914032A (en) * 1985-06-06 1990-04-03 Centro De Investigation Y Estudios Avanzados Del Instituto Politecnico Nacional Process for the long-term surviving culture of hepatocytes
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system

Also Published As

Publication number Publication date
JPH08503610A (en) 1996-04-23
WO1994012662A1 (en) 1994-06-09
EP0673433A1 (en) 1995-09-27
CA2154701A1 (en) 1994-06-09

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