AU5503899A - Antiviral and antiretroviral radioimmunomedicaments based on alpha-emitters and beta-emitters - Google Patents
Antiviral and antiretroviral radioimmunomedicaments based on alpha-emitters and beta-emittersInfo
- Publication number
- AU5503899A AU5503899A AU55038/99A AU5503899A AU5503899A AU 5503899 A AU5503899 A AU 5503899A AU 55038/99 A AU55038/99 A AU 55038/99A AU 5503899 A AU5503899 A AU 5503899A AU 5503899 A AU5503899 A AU 5503899A
- Authority
- AU
- Australia
- Prior art keywords
- virus
- fragment
- emitters
- hiv
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1006—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against or targeting material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to a pharmaceutical preparation comprising a radioimmunological conjugate (RIK) for in-vivo elimination of virus-replicating cells in HIV-1, HIV-2, HIV-3, HTLV-1, HTLV-2, HBV, HCV, HDV, CMV, EBV, HHV8 infections and in other chronic virus infections. The radioimmunological conjugate is characterized in that it contains, as immunologically effective constituents; d) a monoclonal antibody or the antigen-binding fragment thereof against a viral or virus-induced antigen expressed on the plasma membrane of virus-infected cells, or; e) a receptor molecule or the fragment thereof with an affinity to an epitope of the viral structural proteins expressed on the plasma membrane of infected cells; or f) a fragment of the cellular receptor molecule, said fragment being modified by mutagenesis, with an affinity to an epitope of the viral structural proteins expressed on the plasma membrane of infected cells. Said conjugate is also characterized in that it contains d) an alpha emitter or a beta emitter as a radioactive constituent. The inventive pharmaceutical preparation also optionally comprises a pharmaceutical carrier and/or adjuvant.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1998128732 DE19828732A1 (en) | 1998-03-08 | 1998-06-29 | Antiviral and anti-retroviral radio-immuno conjugates, for the treatment of viral infections |
DE19828732 | 1998-06-29 | ||
PCT/DE1999/001894 WO2000000223A2 (en) | 1998-06-29 | 1999-06-29 | ANTIVIRAL AND ANTIRETROVIRAL RADIOIMMUNOMEDICAMENTS BASED ON α-EMITTERS AND β-EMITTERS |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5503899A true AU5503899A (en) | 2000-01-17 |
Family
ID=7872232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU55038/99A Abandoned AU5503899A (en) | 1998-06-29 | 1999-06-29 | Antiviral and antiretroviral radioimmunomedicaments based on alpha-emitters and beta-emitters |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1091763B1 (en) |
JP (1) | JP2002519334A (en) |
AT (1) | ATE249846T1 (en) |
AU (1) | AU5503899A (en) |
DE (1) | DE59907027D1 (en) |
ES (1) | ES2212607T3 (en) |
WO (1) | WO2000000223A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
PE20141434A1 (en) | 2008-07-16 | 2014-10-22 | Inst Research In Biomedicine | NEUTRALIZING ANTIBODIES OF HUMAN CYTOMEGALOVIRUS |
CN106139150B (en) * | 2015-04-10 | 2019-10-08 | 复旦大学 | A kind for the treatment of AIDS vaccine composition and its application |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1339775C (en) * | 1988-06-10 | 1998-03-24 | Shuzo Matsushita | Antibody 0.5b to hiv-i gp 120 modified with toxic substance |
CA1339415C (en) * | 1989-08-24 | 1997-09-02 | Milton David Goldenberg | Detection and treatment of infections with immunoconjugates |
DE4025499A1 (en) * | 1990-08-11 | 1992-02-13 | Sandoz Ag | USE OF THE ANTIKOERPER BR55-2, DERIVATIVES, CONJUGATES AND FRAGMENTS FOR THE TREATMENT OF HIV INFECTIONS |
JPH08502260A (en) * | 1992-09-30 | 1996-03-12 | ザ スクリップス リサーチ インスティテュート | Human neutralizing monoclonal antibody against human immunodeficiency virus |
DE19809785C2 (en) * | 1998-03-08 | 2000-02-10 | Wolfgang Bergter | Radioimmune drug for the treatment of HIV-1 infection |
-
1999
- 1999-06-29 ES ES99941408T patent/ES2212607T3/en not_active Expired - Lifetime
- 1999-06-29 AU AU55038/99A patent/AU5503899A/en not_active Abandoned
- 1999-06-29 WO PCT/DE1999/001894 patent/WO2000000223A2/en active IP Right Grant
- 1999-06-29 EP EP99941408A patent/EP1091763B1/en not_active Expired - Lifetime
- 1999-06-29 DE DE59907027T patent/DE59907027D1/en not_active Expired - Fee Related
- 1999-06-29 JP JP2000556808A patent/JP2002519334A/en active Pending
- 1999-06-29 AT AT99941408T patent/ATE249846T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2000000223A2 (en) | 2000-01-06 |
WO2000000223A3 (en) | 2000-02-17 |
ES2212607T3 (en) | 2004-07-16 |
ATE249846T1 (en) | 2003-10-15 |
DE59907027D1 (en) | 2003-10-23 |
EP1091763A2 (en) | 2001-04-18 |
EP1091763B1 (en) | 2003-09-17 |
JP2002519334A (en) | 2002-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |