AU5087193A - Composition and method for altering dna sequences by homologous recombination - Google Patents
Composition and method for altering dna sequences by homologous recombinationInfo
- Publication number
- AU5087193A AU5087193A AU50871/93A AU5087193A AU5087193A AU 5087193 A AU5087193 A AU 5087193A AU 50871/93 A AU50871/93 A AU 50871/93A AU 5087193 A AU5087193 A AU 5087193A AU 5087193 A AU5087193 A AU 5087193A
- Authority
- AU
- Australia
- Prior art keywords
- composition
- dna sequences
- homologous recombination
- altering dna
- altering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 230000006801 homologous recombination Effects 0.000 title 1
- 238000002744 homologous recombination Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4712—Cystic fibrosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93347192A | 1992-08-21 | 1992-08-21 | |
US933471 | 1992-08-21 | ||
PCT/US1993/007917 WO1994004032A1 (fr) | 1992-08-21 | 1993-08-20 | Composition et procede de modification de sequences d'adn par recombinaison homologue |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5087193A true AU5087193A (en) | 1994-03-15 |
Family
ID=25464029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU50871/93A Abandoned AU5087193A (en) | 1992-08-21 | 1993-08-20 | Composition and method for altering dna sequences by homologous recombination |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0656747A4 (fr) |
AU (1) | AU5087193A (fr) |
WO (1) | WO1994004032A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69333955D1 (de) | 1992-04-24 | 2006-02-02 | Stanford Res Inst Int | Targeting homologer sequenzen in eukaryotenzellen |
US5763240A (en) * | 1992-04-24 | 1998-06-09 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
US5804383A (en) * | 1992-08-21 | 1998-09-08 | The Regents Of The University Of California | Method and assay for detection of the expression of allele-specific mutations by allele-specific in situ reverse transcriptase polymerase chain reaction |
ATE196311T1 (de) * | 1993-12-09 | 2000-09-15 | Univ Jefferson | Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen |
JP3654446B2 (ja) * | 1993-12-23 | 2005-06-02 | メルク アンド カンパニー, インコーポレイテッド | マウス細胞のための相同的組換え抗体発現系 |
SE9402642D0 (sv) * | 1994-08-05 | 1994-08-05 | Maria Anvret | Gene Therapy |
US5780296A (en) * | 1995-01-17 | 1998-07-14 | Thomas Jefferson University | Compositions and methods to promote homologous recombination in eukaryotic cells and organisms |
US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
EP0979311A1 (fr) * | 1997-04-30 | 2000-02-16 | Of The University Of Minnesota Regents | UTILISATION $i(IN VIVO) D'OLIGONUCLEOBASES RECOMBINAGENES POUR CORRIGER LES LESIONS GENETIQUES DES HEPATOCYTES |
ES2255177T5 (es) * | 1997-07-23 | 2011-07-12 | Roche Diagnostics Gmbh | Fabricación de proteínas mutadas humanas en células humanas por medio de la recombinación homóloga. |
GB0218803D0 (en) * | 2002-08-13 | 2002-09-18 | Nl Kanker I | Targeted gene modification by single-standed DNA oligonucleotides |
EP2064325B1 (fr) | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Expression renforcée d'immunoglobuline humaine ou humanisée chez des animaux transgéniques non humains |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2646438B1 (fr) * | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
WO1990014092A1 (fr) * | 1989-05-18 | 1990-11-29 | Cell Genesys, Inc. | Utilisation d'oligonucleotides mono-brins pour la modification axee sur le site de genes mammiferes in vivo |
US5240846A (en) * | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
WO1991019796A1 (fr) * | 1990-06-12 | 1991-12-26 | Baylor College Of Medicine | Procede de recombinaison homologue dans des cellules animales et vegetales |
EP0546091B1 (fr) * | 1990-08-29 | 2007-01-24 | Pharming Intellectual Property BV | Recombinaison homologue dans des cellules de mammiferes |
EP0539573A4 (en) * | 1991-05-15 | 1993-12-29 | Cell Genesys, Inc. | Genomic modifications with homologous dna targeting |
DE69333955D1 (de) * | 1992-04-24 | 2006-02-02 | Stanford Res Inst Int | Targeting homologer sequenzen in eukaryotenzellen |
-
1993
- 1993-08-20 WO PCT/US1993/007917 patent/WO1994004032A1/fr not_active Application Discontinuation
- 1993-08-20 EP EP93920268A patent/EP0656747A4/fr not_active Withdrawn
- 1993-08-20 AU AU50871/93A patent/AU5087193A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0656747A4 (fr) | 1997-05-07 |
WO1994004032A1 (fr) | 1994-03-03 |
EP0656747A1 (fr) | 1995-06-14 |
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