AU5087193A - Composition and method for altering dna sequences by homologous recombination - Google Patents

Composition and method for altering dna sequences by homologous recombination

Info

Publication number
AU5087193A
AU5087193A AU50871/93A AU5087193A AU5087193A AU 5087193 A AU5087193 A AU 5087193A AU 50871/93 A AU50871/93 A AU 50871/93A AU 5087193 A AU5087193 A AU 5087193A AU 5087193 A AU5087193 A AU 5087193A
Authority
AU
Australia
Prior art keywords
composition
dna sequences
homologous recombination
altering dna
altering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU50871/93A
Other languages
English (en)
Inventor
Dieter C Gruenert
Karl Kunzelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of AU5087193A publication Critical patent/AU5087193A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4712—Cystic fibrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU50871/93A 1992-08-21 1993-08-20 Composition and method for altering dna sequences by homologous recombination Abandoned AU5087193A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93347192A 1992-08-21 1992-08-21
US933471 1992-08-21
PCT/US1993/007917 WO1994004032A1 (fr) 1992-08-21 1993-08-20 Composition et procede de modification de sequences d'adn par recombinaison homologue

Publications (1)

Publication Number Publication Date
AU5087193A true AU5087193A (en) 1994-03-15

Family

ID=25464029

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50871/93A Abandoned AU5087193A (en) 1992-08-21 1993-08-20 Composition and method for altering dna sequences by homologous recombination

Country Status (3)

Country Link
EP (1) EP0656747A4 (fr)
AU (1) AU5087193A (fr)
WO (1) WO1994004032A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333955D1 (de) 1992-04-24 2006-02-02 Stanford Res Inst Int Targeting homologer sequenzen in eukaryotenzellen
US5763240A (en) * 1992-04-24 1998-06-09 Sri International In vivo homologous sequence targeting in eukaryotic cells
US5804383A (en) * 1992-08-21 1998-09-08 The Regents Of The University Of California Method and assay for detection of the expression of allele-specific mutations by allele-specific in situ reverse transcriptase polymerase chain reaction
ATE196311T1 (de) * 1993-12-09 2000-09-15 Univ Jefferson Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen
JP3654446B2 (ja) * 1993-12-23 2005-06-02 メルク アンド カンパニー， インコーポレイテッド マウス細胞のための相同的組換え抗体発現系
SE9402642D0 (sv) * 1994-08-05 1994-08-05 Maria Anvret Gene Therapy
US5780296A (en) * 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
US5948653A (en) 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
EP0979311A1 (fr) * 1997-04-30 2000-02-16 Of The University Of Minnesota Regents UTILISATION $i(IN VIVO) D'OLIGONUCLEOBASES RECOMBINAGENES POUR CORRIGER LES LESIONS GENETIQUES DES HEPATOCYTES
ES2255177T5 (es) * 1997-07-23 2011-07-12 Roche Diagnostics Gmbh Fabricación de proteínas mutadas humanas en células humanas por medio de la recombinación homóloga.
GB0218803D0 (en) * 2002-08-13 2002-09-18 Nl Kanker I Targeted gene modification by single-standed DNA oligonucleotides
EP2064325B1 (fr) 2006-09-01 2011-12-07 Therapeutic Human Polyclonals, Inc. Expression renforcée d'immunoglobuline humaine ou humanisée chez des animaux transgéniques non humains

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) * 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
WO1990014092A1 (fr) * 1989-05-18 1990-11-29 Cell Genesys, Inc. Utilisation d'oligonucleotides mono-brins pour la modification axee sur le site de genes mammiferes in vivo
US5240846A (en) * 1989-08-22 1993-08-31 The Regents Of The University Of Michigan Gene therapy vector for cystic fibrosis
WO1991019796A1 (fr) * 1990-06-12 1991-12-26 Baylor College Of Medicine Procede de recombinaison homologue dans des cellules animales et vegetales
EP0546091B1 (fr) * 1990-08-29 2007-01-24 Pharming Intellectual Property BV Recombinaison homologue dans des cellules de mammiferes
EP0539573A4 (en) * 1991-05-15 1993-12-29 Cell Genesys, Inc. Genomic modifications with homologous dna targeting
DE69333955D1 (de) * 1992-04-24 2006-02-02 Stanford Res Inst Int Targeting homologer sequenzen in eukaryotenzellen

Also Published As

Publication number Publication date
EP0656747A4 (fr) 1997-05-07
WO1994004032A1 (fr) 1994-03-03
EP0656747A1 (fr) 1995-06-14

Similar Documents

Publication Publication Date Title
AU6099596A (en) Methods and compositions for effecting homologous recombination
HU9603144D0 (en) Dna construct for effecting homologous recombination and uses thereof
AU4678993A (en) Methods for using dendritic cells to activate t cells
AU7270091A (en) Method and composition for coiontophoresis
AU2410192A (en) Paraffin isomerization process
AU4093497A (en) Silane-treated clay production method, silane-treated clay and composition containing same
AU3890795A (en) Improved method for nucleotide sequence amplification
AU2317095A (en) Dna sequences
AU4783293A (en) Method for screening compositions
EP0522269A3 (en) Method for producing enzyme composition
AU5087193A (en) Composition and method for altering dna sequences by homologous recombination
AU5957894A (en) Tanning method using dna repair liposomes
AU3413895A (en) High amperage solenoid structure
AU4425493A (en) The method of using improved intumescence carriers for fireproof glasses
PH30670A (en) Flavorant composition prepared by fermentation
AU7170394A (en) Selectively-removable indicia-containing surface-coating method
AU6826194A (en) 16-hydroxytriptolide composition and method for immunotherapy
AU2540297A (en) Methods for enriching target nucleic acid sequences
AU5912090A (en) Method for controlling macroinvertebrates utilizing decylthioethylamine
AU1595692A (en) Plant promoter sequences
AU7424594A (en) Method for preparing 3-aminopyridines from 3-nitropyridines
AU6368394A (en) Polymer-polypeptide composition and method
AU7237094A (en) Method for inhibiting the polymerization of vinyl aromatics
AU7596994A (en) Methods and compositions for retarding the aging process
AU2847089A (en) Cathodic protection method and compositions