AU4900397A - Heterocyclic derivatives as factor xa inhibitors - Google Patents

Heterocyclic derivatives as factor xa inhibitors

Info

Publication number
AU4900397A
AU4900397A AU49003/97A AU4900397A AU4900397A AU 4900397 A AU4900397 A AU 4900397A AU 49003/97 A AU49003/97 A AU 49003/97A AU 4900397 A AU4900397 A AU 4900397A AU 4900397 A AU4900397 A AU 4900397A
Authority
AU
Australia
Prior art keywords
inhibitors
factor
heterocyclic derivatives
heterocyclic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU49003/97A
Other versions
AU743614B2 (en
Inventor
Robert M. Scarborough
Bing-Yan Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority claimed from PCT/US1997/018410 external-priority patent/WO1998016524A1/en
Publication of AU4900397A publication Critical patent/AU4900397A/en
Application granted granted Critical
Publication of AU743614B2 publication Critical patent/AU743614B2/en
Assigned to MILLENNIUM PHARMACEUTICALS, INC. reassignment MILLENNIUM PHARMACEUTICALS, INC. Alteration of Name(s) in Register under S187 Assignors: COR THERAPEUTICS, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU49003/97A 1996-10-11 1997-10-10 Heterocyclic derivatives as factor Xa inhibitors Ceased AU743614B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3625796P 1996-10-11 1996-10-11
US73138496A 1996-10-11 1996-10-11
US08/731384 1996-10-11
US60/036257 1996-10-11
PCT/US1997/018410 WO1998016524A1 (en) 1996-10-11 1997-10-10 HETEROCYCLIC DERIVATIVES AS FACTOR Xa INHIBITORS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU97134/01A Division AU9713401A (en) 1996-10-11 2001-12-07 Heterocyclic derivatives as factor Xa inhibitors

Publications (2)

Publication Number Publication Date
AU4900397A true AU4900397A (en) 1998-05-11
AU743614B2 AU743614B2 (en) 2002-01-31

Family

ID=26712982

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49003/97A Ceased AU743614B2 (en) 1996-10-11 1997-10-10 Heterocyclic derivatives as factor Xa inhibitors

Country Status (3)

Country Link
EP (1) EP0939758A1 (en)
JP (1) JP2002515049A (en)
AU (1) AU743614B2 (en)

Also Published As

Publication number Publication date
AU743614B2 (en) 2002-01-31
EP0939758A1 (en) 1999-09-08
JP2002515049A (en) 2002-05-21

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20020606

PC Assignment registered

Owner name: MILLENNIUM PHARMACEUTICALS, INC.

Free format text: FORMER OWNER WAS: COR THERAPEUTICS, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired