AU4876093A - Process for the preparation of sterile beta-lactam antibiotics - Google Patents

Process for the preparation of sterile beta-lactam antibiotics

Info

Publication number
AU4876093A
AU4876093A AU48760/93A AU4876093A AU4876093A AU 4876093 A AU4876093 A AU 4876093A AU 48760/93 A AU48760/93 A AU 48760/93A AU 4876093 A AU4876093 A AU 4876093A AU 4876093 A AU4876093 A AU 4876093A
Authority
AU
Australia
Prior art keywords
preparation
sterile
lactam antibiotics
beta
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU48760/93A
Other versions
AU674021B2 (en
Inventor
Alberto Brandt
Loredana Cecchetelli
Giordano Bruno Corsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Biochimico Italiano Giovanni Lorenzini SpA
Original Assignee
St Biochimico Italiano Giovanni Lorenzini SpA
Istituto Biochimico Italiano Giovanni Lorenzini SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Biochimico Italiano Giovanni Lorenzini SpA, Istituto Biochimico Italiano Giovanni Lorenzini SpA filed Critical St Biochimico Italiano Giovanni Lorenzini SpA
Publication of AU4876093A publication Critical patent/AU4876093A/en
Application granted granted Critical
Publication of AU674021B2 publication Critical patent/AU674021B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/14—Preparation of salts
    • C07D499/16—Preparation of salts of alkali or alkaline earth metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A process for the preparation of sterile sodium amoxycillin characterized by the fact that a solution of amoxycillin trihydrate in a mixture of methyl alcohol and a lower C2-C5 alcohol is reacted in a sterile ambient, optionally in the presence of a suitable amine, with a solution of a suitable salifying agent selected in the group consisting of an alcoholate or carboxylate of sodium in methyl acetate followed by separation of the precipitate is described.
AU48760/93A 1992-10-05 1993-10-04 Process for the preparation of sterile beta-lactam antibiotics Ceased AU674021B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI92A2296 1992-10-05
ITMI922296A IT1255716B (en) 1992-10-05 1992-10-05 PROCEDURE FOR THE PREPARATION OF STERILE BETA-LACTAMIC ANTIBIOTICS

Publications (2)

Publication Number Publication Date
AU4876093A true AU4876093A (en) 1994-04-21
AU674021B2 AU674021B2 (en) 1996-12-05

Family

ID=11364060

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48760/93A Ceased AU674021B2 (en) 1992-10-05 1993-10-04 Process for the preparation of sterile beta-lactam antibiotics

Country Status (13)

Country Link
US (1) US5559241A (en)
EP (1) EP0596262B1 (en)
JP (1) JPH072869A (en)
KR (1) KR970010068B1 (en)
AT (1) ATE138381T1 (en)
AU (1) AU674021B2 (en)
DE (1) DE69302793T2 (en)
DK (1) DK0596262T3 (en)
ES (1) ES2089667T3 (en)
GR (1) GR3020834T3 (en)
IT (1) IT1255716B (en)
NZ (1) NZ248853A (en)
PH (1) PH31252A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW347383B (en) * 1995-10-26 1998-12-11 Biochemie Gmbh A process for the production of a crystalline sodium salt of amoxicillin in ethanol as solvent
US6073052A (en) * 1996-11-15 2000-06-06 Zelickson; Brian D. Device and method for treatment of gastroesophageal reflux disease
IL139736A (en) * 1998-06-01 2004-02-19 Smithkline Beecham Corp Process for preparing crystalline alkali metal salt of amoxycillin
IN191580B (en) 1999-12-17 2003-12-06 Ranbaxy Lab Ltd
ITMI20011718A1 (en) 2001-08-03 2003-02-03 Istituto Biochimico Italiano PROCESS FOR THE PREPARATION OF SODIUM SALT OF THE ACID-6 (D - (-) - ALPHA- (4-ETHYL-2,3-DIOXY-1-PIPERAZINOCARBONYLAMINE) PHENYLACETAMIDE) PENICILL
ITMI20051630A1 (en) * 2005-09-02 2007-03-03 Acs Dobfar Spa INJECTABLE STERILE PHARMACEUTICAL FORMULATION CONTAINING AT LEAST TWO ACTIVE PRINCIPLES
MX2012014758A (en) * 2010-06-16 2013-10-01 Vardhman Chemtech Ltd Improved process for preparing amoxicillin sodium.
JP7322568B2 (en) * 2019-07-25 2023-08-08 カシオ計算機株式会社 Memory system, control method and program

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639104A (en) * 1962-11-02
GB1543317A (en) * 1976-08-04 1979-04-04 Beecham Group Ltd Process for the preparation of sodium amoxycillin
DK456580A (en) * 1979-10-29 1981-06-04 Beecham Group Ltd PROCEDURE FOR PREPARING BICYCLIC BETA-LACTAMRING COMPOUNDS
FR2503710B1 (en) * 1981-04-10 1985-07-05 Bristol Myers Co PROCESS FOR PRODUCING SODIUM SALT OF AMOXICILLIN
DE3474023D1 (en) * 1983-06-10 1988-10-20 Beecham Group Plc Crystalline amoxycillin salt
ES8606871A1 (en) * 1985-10-21 1986-06-01 Antibioticos Sa A process for the preparation of sodium amoxycillin.

Also Published As

Publication number Publication date
PH31252A (en) 1998-06-18
DK0596262T3 (en) 1996-10-07
JPH072869A (en) 1995-01-06
EP0596262B1 (en) 1996-05-22
AU674021B2 (en) 1996-12-05
ES2089667T3 (en) 1996-10-01
KR970010068B1 (en) 1997-06-20
DE69302793T2 (en) 1997-01-23
NZ248853A (en) 1995-10-26
KR940009206A (en) 1994-05-20
ATE138381T1 (en) 1996-06-15
ITMI922296A1 (en) 1994-04-05
IT1255716B (en) 1995-11-10
ITMI922296A0 (en) 1992-10-05
GR3020834T3 (en) 1996-11-30
DE69302793D1 (en) 1996-06-27
EP0596262A1 (en) 1994-05-11
US5559241A (en) 1996-09-24

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired