AU3808595A - Novel acid pyrazole and pyrazolone derivatives for use as endothelin receptor antagonists - Google Patents

Novel acid pyrazole and pyrazolone derivatives for use as endothelin receptor antagonists

Info

Publication number
AU3808595A
AU3808595A AU38085/95A AU3808595A AU3808595A AU 3808595 A AU3808595 A AU 3808595A AU 38085/95 A AU38085/95 A AU 38085/95A AU 3808595 A AU3808595 A AU 3808595A AU 3808595 A AU3808595 A AU 3808595A
Authority
AU
Australia
Prior art keywords
receptor antagonists
endothelin receptor
pyrazolone derivatives
novel acid
acid pyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU38085/95A
Inventor
Michel Fortin
Jidong Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU3808595A publication Critical patent/AU3808595A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
AU38085/95A 1994-10-24 1995-10-20 Novel acid pyrazole and pyrazolone derivatives for use as endothelin receptor antagonists Abandoned AU3808595A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9412676 1994-10-24
FR9412676A FR2725988B1 (en) 1994-10-24 1994-10-24 NEW DERIVATIVES OF PYRAZOLONES AND ACID PYRAZOLES, THEIR PROCESS OF PREPARATION, THE NEW INTERMEDIARIES OBTAINED, THEIR APPLICATION AS MEDICINAL PRODUCTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR1995/001386 WO1996012706A1 (en) 1994-10-24 1995-10-20 Novel acid pyrazole and pyrazolone derivatives for use as endothelin receptor antagonists

Publications (1)

Publication Number Publication Date
AU3808595A true AU3808595A (en) 1996-05-15

Family

ID=9468134

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38085/95A Abandoned AU3808595A (en) 1994-10-24 1995-10-20 Novel acid pyrazole and pyrazolone derivatives for use as endothelin receptor antagonists

Country Status (5)

Country Link
AU (1) AU3808595A (en)
FR (1) FR2725988B1 (en)
IL (1) IL115653A0 (en)
WO (1) WO1996012706A1 (en)
ZA (1) ZA958995B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252817B2 (en) 2005-04-28 2012-08-28 Bayer Intellectual Property Gmbh Dipyridyl-dihydropyrazolones and their use
US9533972B2 (en) 2010-11-18 2017-01-03 Bayer Intellectual Property Gmbh Substituted sodium-1H-pyrazole-5-olate

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740135B1 (en) * 1995-10-20 1997-12-19 Roussel Uclaf NOVEL ACID PYRAZOLES DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, THEIR NEW USE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE19645313A1 (en) 1996-11-04 1998-05-07 Basf Ag Substituted 3-benzylpyrazoles
DE19653024A1 (en) * 1996-12-19 1998-06-25 Merck Patent Gmbh Endothelin receptor antagonists
EP1735284A1 (en) 2004-03-18 2006-12-27 Pfizer Limited N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
DE102008020113A1 (en) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituted dihydropyrazolones and their use
NL2000351C2 (en) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogen modulators.
DE102006050513A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New substituted dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia
DE102006050515A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New substituted dipyridiyl-dihydropyrazolone derivatives are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful to treat/prevent e.g. cardiovascular diseases, heart-circulation diseases, heart failure and anemia
DE102006050516A1 (en) 2006-10-26 2008-04-30 Bayer Healthcare Ag New pyrazol-3-one compounds are hypoxia-inducible transcription factor-prolyl-4-hydroxylase inhibitors useful e.g. to treat and/or prophylaxis heart-circulation diseases, heart failure, anemia, chronic kidney diseases and renal failure
DE102007044032A1 (en) 2007-09-14 2009-03-19 Bayer Healthcare Ag New substituted heteroaryl compounds are hypoxia-inducible factor prolyl-4-hydroxylase inhibitors useful to treat and/or prevent e.g. circulatory heart diseases, heart failure, anemia, chronic kidney diseases and renal failure
DE102007048447A1 (en) 2007-10-10 2009-04-16 Bayer Healthcare Ag New substituted dihydropyrazole-3-thione compounds are hypoxia inducible factor-prolyl-4-hydroxylase inhibitor, useful for preparing medicament to treat and/or prevent e.g. cardiovascular diseases, wound healing and anemia
CN106029640B (en) 2014-02-14 2018-08-24 泰普斯特医疗公司 Pyrazolinone compounds and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672891B1 (en) * 1991-02-20 1994-02-18 Synthelabo DERIVATIVES OF 3-PYRAZOLONES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
NZ247440A (en) * 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
AU4679793A (en) * 1992-07-17 1994-02-14 Smithkline Beecham Corporation Endothelin receptor antagonists

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252817B2 (en) 2005-04-28 2012-08-28 Bayer Intellectual Property Gmbh Dipyridyl-dihydropyrazolones and their use
US9085572B2 (en) 2005-04-28 2015-07-21 Bayer Intellectual Property Gmbh 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases
US9533972B2 (en) 2010-11-18 2017-01-03 Bayer Intellectual Property Gmbh Substituted sodium-1H-pyrazole-5-olate

Also Published As

Publication number Publication date
WO1996012706A1 (en) 1996-05-02
IL115653A0 (en) 1996-01-19
FR2725988B1 (en) 1997-01-24
ZA958995B (en) 1996-10-24
FR2725988A1 (en) 1996-04-26

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