AU3771700A - Methods for treating neurodegenerative disorders using aspartyl protease inhibitors - Google Patents

Methods for treating neurodegenerative disorders using aspartyl protease inhibitors Download PDF

Info

Publication number
AU3771700A
AU3771700A AU37717/00A AU3771700A AU3771700A AU 3771700 A AU3771700 A AU 3771700A AU 37717/00 A AU37717/00 A AU 37717/00A AU 3771700 A AU3771700 A AU 3771700A AU 3771700 A AU3771700 A AU 3771700A
Authority
AU
Australia
Prior art keywords
substituted
group
cathepsin
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37717/00A
Other languages
English (en)
Inventor
Xiaoning Bi
Jonathan A Ellman
Tasir Haque
Irwin D Kuntz
Christina E. Lee
Gary Lynch
A. Geoffrey Skillman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of AU3771700A publication Critical patent/AU3771700A/en
Priority to AU2005201481A priority Critical patent/AU2005201481A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AU37717/00A 1999-03-24 2000-03-24 Methods for treating neurodegenerative disorders using aspartyl protease inhibitors Abandoned AU3771700A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2005201481A AU2005201481A1 (en) 1999-03-24 2005-04-07 Methods for treating neurodegenerative disorders using aspartyl protease inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12595899P 1999-03-24 1999-03-24
US60125958 1999-03-24
PCT/US2000/007804 WO2000056335A1 (fr) 1999-03-24 2000-03-24 Traitement des maladies neurodegeneratives par des inhibiteurs de l'aspartyl protease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2005201481A Division AU2005201481A1 (en) 1999-03-24 2005-04-07 Methods for treating neurodegenerative disorders using aspartyl protease inhibitors

Publications (1)

Publication Number Publication Date
AU3771700A true AU3771700A (en) 2000-10-09

Family

ID=22422250

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37717/00A Abandoned AU3771700A (en) 1999-03-24 2000-03-24 Methods for treating neurodegenerative disorders using aspartyl protease inhibitors

Country Status (5)

Country Link
EP (1) EP1178800A4 (fr)
JP (1) JP2002539260A (fr)
AU (1) AU3771700A (fr)
CA (1) CA2367112A1 (fr)
WO (1) WO2000056335A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080059687A (ko) 2000-03-06 2008-06-30 아카디아 파마슈티칼스 인코포레이티드 세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물
EP1666452A2 (fr) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Composés pour le traitement de la maladie d'Alzheimer
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
WO2002014264A2 (fr) 2000-08-11 2002-02-21 The Brigham And Women's Hospital, Inc. (hydroxyethyl)urees utilisees en tant qu'inhibiteurs de la production de beta-amyloide de la maladie d'alhzeimer
AU2002314914A1 (en) * 2001-06-01 2002-12-16 Elan Pharmaceuticals, Inc. Hydroxy alkyl amine derivatives as beta-secretase inhibitors and their use for the treatment of alzheimer's disease and similar diseases
BR0213139A (pt) 2001-10-04 2004-08-10 Elan Pharm Inc Composto, método de tratamento ou prevenção de doenças e de preparação de um composto, uso de um composto e composição farmacêutica
BR0214736A (pt) * 2001-12-06 2004-11-23 Elan Pharm Inc Composto e seus sais farmaceuticamente aceitáveis, composição farmacêutica e método de tratar seres humanos ou animais que sofrem de doenças ou condições
WO2003057698A2 (fr) 2001-12-28 2003-07-17 Acadia Pharmaceuticals, Inc. Composes spiroazacycliques utilises comme modulateurs du recepteur de monoamine
AU2003303141A1 (en) 2002-04-30 2004-07-22 Elan Pharmaceuticals, Inc. Hydroxypropyl amides for the treatment of alzheimer's disease
US7115652B2 (en) 2002-06-17 2006-10-03 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
US7132568B2 (en) 2002-06-17 2006-11-07 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
NZ537522A (en) 2002-06-24 2006-07-28 Acadia Pharm Inc N-substituted piperidine derivatives as serotonin receptor agents
MXPA05007568A (es) 2003-01-16 2005-09-21 Acadia Pharm Inc Agonistas inversos del receptor selectivo de serotonina 2a/2c como terapeuticos para enfermedades neurodegenerativas.
AU2003297826A1 (en) * 2003-06-16 2005-01-28 Sunesis Pharmaceuticals, Inc Aspartyl protease inhibitors
TW200524910A (en) * 2003-08-08 2005-08-01 Schering Corp Cyclic amine BACE-1 inhibitors having a heterocyclic substituent
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
PL2289879T3 (pl) 2004-09-27 2015-05-29 Acadia Pharm Inc Synteza formy krystalicznej soli winianowej n-(4-fluorobenzylo)-n-(1-metylopiperydyn-4-ylo)-n'-(4-(2-metylopropyloksy)fenylometylo)karbamidu
WO2008116024A2 (fr) 2007-03-19 2008-09-25 Acadia Pharmaceuticals Inc. Combinaisons d'agonistes ou antagonistes inverses de 5-ht2a avec antipsychotiques
JP2011518188A (ja) 2008-04-18 2011-06-23 ユニバーシティ オブ コネチカット リソソーム調節のための化合物および使用方法
PT3325444T (pt) 2015-07-20 2021-09-22 Acadia Pharm Inc Métodos para preparar n-(4-fluorobenzil)-n-(1-metilpiperidina-4-il)-n'-(4-(2-metilpropiloxi)fenilmetil)carbamida e o seu sal de tartarato e forma polimórfica c
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (fr) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Association de pimavansérine et de modulateurs du cytochrome p450
WO2018118626A1 (fr) 2016-12-20 2018-06-28 Acadia Pharmaceuticals Inc. Pimavansérine seule ou en association pour une utilisation dans le traitement de la psychose liée à la maladie d'alzheimer
EP3615028A1 (fr) 2017-04-28 2020-03-04 Acadia Pharmaceuticals Inc. Pimavansérine pour le traitement d'un trouble de contrôle des impulsions
WO2019046167A1 (fr) 2017-08-30 2019-03-07 Acadia Pharmaceuticals Inc. Formulations de pimavansérine
CA3107352A1 (fr) 2018-07-23 2020-01-30 Enclear Therapies, Inc. Methodes de traitement de troubles neurologiques
WO2020023417A1 (fr) * 2018-07-23 2020-01-30 Enclear Therapies, Inc. Méthodes de traitement de troubles neurologiques
JP2022526671A (ja) 2019-04-11 2022-05-25 エンクリアー セラピーズ， インク． 脳脊髄液の改善の方法ならびにそのためのデバイスおよびシステム

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2280096A1 (fr) * 1997-02-04 1998-08-06 The Regents Of The University Of California Inhibiteurs de cathepsine d nanomolaires et non peptidiques

Also Published As

Publication number Publication date
EP1178800A1 (fr) 2002-02-13
JP2002539260A (ja) 2002-11-19
WO2000056335A1 (fr) 2000-09-28
CA2367112A1 (fr) 2000-09-28
EP1178800A4 (fr) 2002-07-31

Similar Documents

Publication Publication Date Title
AU3771700A (en) Methods for treating neurodegenerative disorders using aspartyl protease inhibitors
JP7419486B2 (ja) τリン酸化を阻害する方法
AU723658B2 (en) Reversible cysteine protease inhibitors
US6150416A (en) Nanomolar, non-peptide inhibitors of cathepsin D
AU2002239727B2 (en) Inhibitors of memapsin 2 and use thereof
KR20000048577A (ko) 인다논으로 26ｓ 및 20ｓ 프로테아좀을 억제하는 방법
AU2002239727A1 (en) Inhibitors of memapsin 2 and use thereof
MXPA02002578A (es) Compuestos de union a ciclofilina no peptidicos, y su uso.
US6696488B2 (en) (Hydroxyethyl)ureas as inhibitors of alzheimer's β-amyloid production
WO2011076854A1 (fr) Clivage de protéine précurseur de β-amyloïde
US7119105B2 (en) Methods for treating neurodegenerative disorders using aspartyl protease inhibitors
EP1931656B1 (fr) Nouveaux medicaments contre la demence
AU2005201481A1 (en) Methods for treating neurodegenerative disorders using aspartyl protease inhibitors
KR20090033583A (ko) 글라이신 아릴 아마이드를 포함하는 신규한베타-세크리타제 저해용 화합물
JP2011518188A (ja) リソソーム調節のための化合物および使用方法
US6846805B2 (en) Helical peptidomimetics
WO2014025785A2 (fr) Ligands de protéine prion en tant qu'agents thérapeutiques pour des troubles neurodégénératifs
KR20090034009A (ko) 글라이신 모액을 포함하는 신규한 베타-세크리타제 저해용화합물