AU3634193A - Novel pyridone derivatives, preparation method therefor, novel intermediates thereby obtained, their use as drugs, and pharmaceutical compositions containing same - Google Patents

Novel pyridone derivatives, preparation method therefor, novel intermediates thereby obtained, their use as drugs, and pharmaceutical compositions containing same

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Publication number
AU3634193A
AU3634193A AU36341/93A AU3634193A AU3634193A AU 3634193 A AU3634193 A AU 3634193A AU 36341/93 A AU36341/93 A AU 36341/93A AU 3634193 A AU3634193 A AU 3634193A AU 3634193 A AU3634193 A AU 3634193A
Authority
AU
Australia
Prior art keywords
radical
novel
drugs
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU36341/93A
Other versions
AU667880B2 (en
Inventor
Michel Fortin
Jean-Luc Haesslein
Bertrand Heckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of AU3634193A publication Critical patent/AU3634193A/en
Application granted granted Critical
Publication of AU667880B2 publication Critical patent/AU667880B2/en
Assigned to HOECHST MARION ROUSSEL reassignment HOECHST MARION ROUSSEL Alteration of Name(s) in Register under S187 Assignors: ROUSSEL-UCLAF
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Products of formula (I), wherein R1?, R2?, R3? and R4? are a hydrogen atom, a halogen atom, or a hydroxyl, mercapto, cyano, nitro, sulpho, formyl, benzoyl, acyl, carboxy, cycloalkyl or acyloxy radical; an alkyl, alkenyl, alkynyl, alkyloxy or alkylthio radical; an aryl, arylalkyl, arylalkenyl, aryloxy or arylthio radical; a radical (a), (b) or (c); a radical -(CH2?)m1?-S(O)m2?-Z'-R'14? wherein m1 is an integer from 0 to 4, m2 is an integer from 0 to 2, R5? is a divalent alkylene radical, and Y is a radical -Y1?-B-Y2?. The products have interesting pharmacological properties which justify their use as drugs.
AU36341/93A 1992-02-07 1993-02-05 Novel pyridone derivatives, preparation method therefor, novel intermediates thereby obtained, their use as drugs, and pharmaceutical compositions containing same Ceased AU667880B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9201390 1992-02-07
FR9201390A FR2687674B1 (en) 1992-02-07 1992-02-07 NEW PYRIDONE DERIVATIVES, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
PCT/FR1993/000118 WO1993016049A1 (en) 1992-02-07 1993-02-05 Novel pyridone derivatives, preparation method therefor, novel intermediates thereby obtained, their use as drugs, and pharmaceutical compositions containing same

Publications (2)

Publication Number Publication Date
AU3634193A true AU3634193A (en) 1993-09-03
AU667880B2 AU667880B2 (en) 1996-04-18

Family

ID=9426432

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36341/93A Ceased AU667880B2 (en) 1992-02-07 1993-02-05 Novel pyridone derivatives, preparation method therefor, novel intermediates thereby obtained, their use as drugs, and pharmaceutical compositions containing same

Country Status (13)

Country Link
EP (1) EP0579819B1 (en)
JP (1) JPH06506956A (en)
KR (1) KR100273181B1 (en)
AT (1) ATE313530T1 (en)
AU (1) AU667880B2 (en)
CA (1) CA2106758A1 (en)
DE (1) DE69333944T2 (en)
ES (1) ES2251714T3 (en)
FR (1) FR2687674B1 (en)
HU (1) HUT68756A (en)
RU (1) RU2124004C1 (en)
WO (1) WO1993016049A1 (en)
ZA (1) ZA93810B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036628A1 (en) * 1995-05-19 1996-11-21 Biota Scientific Management Pty. Ltd. 6-carboxamido dihydropyran derivatives

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0759917T3 (en) * 1995-02-27 2000-07-31 Gilead Sciences Inc Novel selective inhibitors of viral or bacterial neuraminidases
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US5994377A (en) * 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
JP4556241B2 (en) * 2003-02-05 2010-10-06 日本曹達株式会社 Novel 6-fluoroalkyl-2 (1H) -pyridinone, 6-fluoroalkylpyridine compound and process for producing the same
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
BR112012021652A2 (en) * 2010-03-04 2016-06-21 Merck Sharp & Dohme compound use thereof and pharmaceutical composition

Family Cites Families (19)

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US4046769A (en) * 1976-10-29 1977-09-06 Warner-Lambert Company 4,10-Dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-2-carboxylic acids and esters
JPS56115784A (en) * 1980-02-15 1981-09-11 Tanabe Seiyaku Co Ltd Novel pyridinecarboxamide derivative and its preparation
ZA813029B (en) * 1980-05-12 1982-05-26 Rohm & Haas Novel substituted oxonicotinates,their use as plant growth regulators and plant growth regulating compositions containing them
US4886744A (en) * 1985-04-25 1989-12-12 Polaroid Corporation Fluorescent conjugates and biological diagnostic assay system
EP0276204A3 (en) * 1987-01-07 1989-06-07 Monsanto Company Pyridine gametocides
US4747871A (en) * 1987-01-07 1988-05-31 Monsanto Company 2,6-bis(trifluoromethyl)-3-hydroxycarbonyl pyridine, salts and gametocides
US4751073A (en) * 1987-06-03 1988-06-14 Olin Corporation Selected 2,2,6,6-tetraalkyl-4-piperidinyl derivatives and their use as light stabilizers
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DE3826846A1 (en) * 1988-08-06 1990-02-08 Goedecke Ag ALKOXY-4 (1H) -PYRIDONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS DRUGS
US5077142A (en) * 1989-04-20 1991-12-31 Ricoh Company, Ltd. Electroluminescent devices
ATE250587T1 (en) * 1989-06-14 2003-10-15 Smithkline Beecham Corp IMIDAZOALGENIC ACID
DE69025473T2 (en) * 1989-06-30 1996-10-17 Du Pont SUBSTITUTED IMIDAZOLES AND THEIR USE AS AN INHIBITANT FOR ANGIOTENSIN II
CA2036618C (en) * 1990-02-22 2002-10-29 Akira Morimoto Fused thiophene derivatives, their production and use
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
GB9005518D0 (en) * 1990-03-12 1990-05-09 Wellcome Found Heterocyclic compounds
AU653734B2 (en) * 1990-06-19 1994-10-13 Meiji Seika Kabushiki Kaisha Substituted 4-biphenylmethoxypyridine derivatives
WO1992000290A1 (en) * 1990-06-29 1992-01-09 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036628A1 (en) * 1995-05-19 1996-11-21 Biota Scientific Management Pty. Ltd. 6-carboxamido dihydropyran derivatives
AU709127B2 (en) * 1995-05-19 1999-08-19 Biota Scientific Management Pty Ltd 6-carboxamido dihydropyran derivatives

Also Published As

Publication number Publication date
FR2687674A1 (en) 1993-08-27
JPH06506956A (en) 1994-08-04
ATE313530T1 (en) 2006-01-15
HU9303144D0 (en) 1994-01-28
KR100273181B1 (en) 2000-12-01
ZA93810B (en) 1994-02-07
FR2687674B1 (en) 1995-05-19
DE69333944D1 (en) 2006-01-26
EP0579819A1 (en) 1994-01-26
HUT68756A (en) 1995-07-28
DE69333944T2 (en) 2006-08-10
RU2124004C1 (en) 1998-12-27
CA2106758A1 (en) 1993-08-08
ES2251714T3 (en) 2006-05-01
EP0579819B1 (en) 2005-12-21
WO1993016049A1 (en) 1993-08-19
AU667880B2 (en) 1996-04-18

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Legal Events

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired