AU3629189A - Cholestadiene derivatives, a process for the preparation thereof, and the use thereof as pharmaceuticals acting to inhibit hmg-coa reductase - Google Patents

Cholestadiene derivatives, a process for the preparation thereof, and the use thereof as pharmaceuticals acting to inhibit hmg-coa reductase

Info

Publication number
AU3629189A
AU3629189A AU36291/89A AU3629189A AU3629189A AU 3629189 A AU3629189 A AU 3629189A AU 36291/89 A AU36291/89 A AU 36291/89A AU 3629189 A AU3629189 A AU 3629189A AU 3629189 A AU3629189 A AU 3629189A
Authority
AU
Australia
Prior art keywords
cholestadiene
derivatives
preparation
coa reductase
inhibit hmg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU36291/89A
Inventor
Ernold Granzer
Wolfgang Hermann Kreiser
Peter Scharein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU3629189A publication Critical patent/AU3629189A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU36291/89A 1988-06-14 1989-06-13 Cholestadiene derivatives, a process for the preparation thereof, and the use thereof as pharmaceuticals acting to inhibit hmg-coa reductase Abandoned AU3629189A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3820177A DE3820177A1 (en) 1988-06-14 1988-06-14 CHOLESTADIEN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICAMENT WITH HMG COA REDUCTASE-INHIBITOR EFFECT
DE3820177 1988-06-14

Publications (1)

Publication Number Publication Date
AU3629189A true AU3629189A (en) 1989-12-21

Family

ID=6356493

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36291/89A Abandoned AU3629189A (en) 1988-06-14 1989-06-13 Cholestadiene derivatives, a process for the preparation thereof, and the use thereof as pharmaceuticals acting to inhibit hmg-coa reductase

Country Status (11)

Country Link
EP (1) EP0346759A3 (en)
JP (1) JPH0236192A (en)
KR (1) KR910000786A (en)
AU (1) AU3629189A (en)
DE (1) DE3820177A1 (en)
DK (1) DK288989A (en)
FI (1) FI892867A (en)
IL (1) IL90572A0 (en)
NO (1) NO892441L (en)
PT (1) PT90843A (en)
ZA (1) ZA894469B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200066690A (en) 2017-10-16 2020-06-10 칭화대학교 Mevalonate pathway inhibitors and pharmaceutical compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107188A (en) * 1977-04-22 1978-08-15 Hoffmann-La Roche Inc. Pregnanes

Also Published As

Publication number Publication date
FI892867A (en) 1989-12-15
EP0346759A3 (en) 1990-01-31
DE3820177A1 (en) 1989-12-21
DK288989D0 (en) 1989-06-13
KR910000786A (en) 1991-01-30
NO892441D0 (en) 1989-06-13
EP0346759A2 (en) 1989-12-20
IL90572A0 (en) 1990-01-18
PT90843A (en) 1989-12-29
FI892867A0 (en) 1989-06-12
NO892441L (en) 1989-12-15
ZA894469B (en) 1990-02-28
DK288989A (en) 1989-12-15
JPH0236192A (en) 1990-02-06

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