AU3628293A - Hybrid DNA that codes for a subunit of a bacterial toxin with a hemolysin - Google Patents

Hybrid DNA that codes for a subunit of a bacterial toxin with a hemolysin

Info

Publication number
AU3628293A
AU3628293A AU36282/93A AU3628293A AU3628293A AU 3628293 A AU3628293 A AU 3628293A AU 36282/93 A AU36282/93 A AU 36282/93A AU 3628293 A AU3628293 A AU 3628293A AU 3628293 A AU3628293 A AU 3628293A
Authority
AU
Australia
Prior art keywords
hemolysin
subunit
codes
hybrid dna
bacterial toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU36282/93A
Other versions
AU672388B2 (en
Inventor
Himanshu Brahmbhatt
Guo-Fu Su
Kenneth N. Timmis
Jurgen Wehland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Original Assignee
Ges fur Biotechnologische Forschung Mbh
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ges fur Biotechnologische Forschung Mbh, Helmholtz Zentrum fuer Infektionsforschung HZI GmbH filed Critical Ges fur Biotechnologische Forschung Mbh
Publication of AU3628293A publication Critical patent/AU3628293A/en
Application granted granted Critical
Publication of AU672388B2 publication Critical patent/AU672388B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

A hybrid DNA is characterized in that a DNA structure that codes for a subunit of a bacterial toxin is fused with a H1yA (hemolysin)-coding DNA structure or its C-terminal fragment. Also disclosed are plasmides, host strains, oligohybridpeptides and vaccines obtained by use of said hybrid DNA.
AU36282/93A 1992-02-17 1993-02-12 Hybrid DNA that codes for a subunit of a bacterial toxin with a hemolysin Ceased AU672388B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4204737 1992-02-17
DE4204737 1992-02-17
DE4219696A DE4219696A1 (en) 1992-02-17 1992-06-16 HYBRID DNA, PLASMIDE, OLIGOHYBRIDEPEPTIDE AND VACCINE
DE4219696 1992-06-16
PCT/EP1993/000348 WO1993016186A1 (en) 1992-02-17 1993-02-12 Hybrid dna that codes for a subunit of a bacterial toxin with a hemolysin

Publications (2)

Publication Number Publication Date
AU3628293A true AU3628293A (en) 1993-09-03
AU672388B2 AU672388B2 (en) 1996-10-03

Family

ID=25911935

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36282/93A Ceased AU672388B2 (en) 1992-02-17 1993-02-12 Hybrid DNA that codes for a subunit of a bacterial toxin with a hemolysin

Country Status (8)

Country Link
EP (1) EP0627006B1 (en)
JP (1) JPH07505052A (en)
AT (1) ATE152483T1 (en)
AU (1) AU672388B2 (en)
DE (2) DE4219696A1 (en)
DK (1) DK0627006T3 (en)
ES (1) ES2104130T3 (en)
WO (1) WO1993016186A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766193B1 (en) * 1997-07-18 2001-09-14 Inst Curie CHEMICAL POLYPEPTIDE COMPRISING FRAGMENT B OF TOXIN SHIGA AND PEPTIDES OF THERAPEUTIC INTEREST
US20020081307A1 (en) 1998-05-15 2002-06-27 Allan M. Green Verotoxin b subunit for immunization
US6264087B1 (en) 1999-07-12 2001-07-24 Powermed, Inc. Expanding parallel jaw device for use with an electromechanical driver device
EP1057895A1 (en) * 1999-06-04 2000-12-06 Lohmann Animal Health GmbH & Co. KG Fusion protein comprising Shiga toxin 2e B subunit, (vaccine)compositions comprising it, and methods for their production

Also Published As

Publication number Publication date
EP0627006B1 (en) 1997-05-02
ATE152483T1 (en) 1997-05-15
DE4219696A1 (en) 1993-08-19
WO1993016186A1 (en) 1993-08-19
DE59306342D1 (en) 1997-06-05
JPH07505052A (en) 1995-06-08
EP0627006A1 (en) 1994-12-07
ES2104130T3 (en) 1997-10-01
AU672388B2 (en) 1996-10-03
DK0627006T3 (en) 1997-11-03

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired