AU3537099A - Novel immortalized hepatic cell line originating in humans - Google Patents

Novel immortalized hepatic cell line originating in humans

Info

Publication number
AU3537099A
AU3537099A AU35370/99A AU3537099A AU3537099A AU 3537099 A AU3537099 A AU 3537099A AU 35370/99 A AU35370/99 A AU 35370/99A AU 3537099 A AU3537099 A AU 3537099A AU 3537099 A AU3537099 A AU 3537099A
Authority
AU
Australia
Prior art keywords
xenobiotics
metabolism
inhibits
liver
promotes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35370/99A
Inventor
Satoru Asahi
Kenichi Fukaya
Masayoshi Nanba
Sumie Yoshitomi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AU3537099A publication Critical patent/AU3537099A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a new immortalized hepatocyte culture of human (preferably human fetal) normal cell origin, a method of producing said culture, a screening method for a compound or a salt thereof which inhibits or promotes an enzyme activity involved in the metabolism of xenobiotics in the liver, or which inhibits or promotes the expression of a gene encoding an enzyme involved in the metabolism of xenobiotics in the liver, or which inhibits or promotes the induction of expression of a gene encoding an enzyme involved in the metabolism of xenobiotics in the liver, characterized by the use of said culture, a compound which inhibits or promotes an enzyme activity involved in the metabolism of xenobiotics in the liver, a compound which inhibits or promotes the expression of a gene encoding an enzyme involved in the metabolism of xenobiotics in the liver, or a compound which inhibits or promotes the induction of expression of a gene encoding an enzyme involved in the metabolism of xenobiotics in the liver, obtained using said screening method, or salts thereof. The immortalized hepatocyte culture of human normal cell origin of the present invention is useful in, for example, screening for compounds or salts thereof having therapeutic/preventive effects on hepatic insufficiency .
AU35370/99A 1998-04-28 1999-04-27 Novel immortalized hepatic cell line originating in humans Abandoned AU3537099A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10/119394 1998-04-28
JP11939498 1998-04-28
PCT/JP1999/002224 WO1999055853A1 (en) 1998-04-28 1999-04-27 Novel immortalized hepatic cell line originating in humans

Publications (1)

Publication Number Publication Date
AU3537099A true AU3537099A (en) 1999-11-16

Family

ID=14760421

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35370/99A Abandoned AU3537099A (en) 1998-04-28 1999-04-27 Novel immortalized hepatic cell line originating in humans

Country Status (7)

Country Link
US (1) US7186553B1 (en)
EP (1) EP1083223B1 (en)
AT (1) ATE341620T1 (en)
AU (1) AU3537099A (en)
CA (1) CA2329857A1 (en)
DE (1) DE69933445T2 (en)
WO (1) WO1999055853A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
FR2828212B1 (en) * 2001-08-03 2003-10-31 Aventis Pharma Sa METHODS OF DIAGNOSING AND PROGNOSING PARKINSON'S DISEASE
EP1704227B1 (en) 2003-10-10 2010-01-27 Multicell Technologies, Inc. Immortalized hepatocytes
US10004826B2 (en) 2010-10-06 2018-06-26 Massachusetts Institute Of Technology Implantable human liver tissue constructs and uses thereof
WO2017062757A1 (en) 2015-10-08 2017-04-13 Massachusetts Institute Of Technology In situ expansion of engineered devices for regeneration
US20210222128A1 (en) 2020-01-22 2021-07-22 Massachusetts Institute Of Technology Inducible tissue constructs and uses thereof
WO2022015902A1 (en) 2020-07-14 2022-01-20 Massachusetts Institute Of Technology Synthetic heparin mimetics and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506131A (en) * 1987-06-05 1996-04-09 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450 genes
US5665589A (en) * 1988-12-14 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Human liver epithelial cell lines
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
WO1998008935A1 (en) * 1996-08-30 1998-03-05 The University Of North Carolina At Chapel Hill Immortalized human hepatic cell line
ATE514773T1 (en) 1999-04-27 2011-07-15 Takeda Pharmaceutical HUMAN CELL LINES THAT EXHIBIT STABLE PRODUCTION OF CYTOCHROME P450

Also Published As

Publication number Publication date
DE69933445T2 (en) 2007-02-22
ATE341620T1 (en) 2006-10-15
US7186553B1 (en) 2007-03-06
CA2329857A1 (en) 1999-11-04
EP1083223B1 (en) 2006-10-04
DE69933445D1 (en) 2006-11-16
EP1083223A4 (en) 2004-12-15
EP1083223A1 (en) 2001-03-14
WO1999055853A1 (en) 1999-11-04

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase