AU3005697A - Ribozyme variants with improved catalytic activity under low magnesium conditions - Google Patents

Ribozyme variants with improved catalytic activity under low magnesium conditions

Info

Publication number
AU3005697A
AU3005697A AU30056/97A AU3005697A AU3005697A AU 3005697 A AU3005697 A AU 3005697A AU 30056/97 A AU30056/97 A AU 30056/97A AU 3005697 A AU3005697 A AU 3005697A AU 3005697 A AU3005697 A AU 3005697A
Authority
AU
Australia
Prior art keywords
catalytic activity
under low
activity under
improved catalytic
low magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU30056/97A
Inventor
Martin Zillman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of AU3005697A publication Critical patent/AU3005697A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
AU30056/97A 1996-05-13 1997-05-13 Ribozyme variants with improved catalytic activity under low magnesium conditions Abandoned AU3005697A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64757796A 1996-05-13 1996-05-13
US08647577 1996-05-13
US80054997A 1997-02-18 1997-02-18
US08800549 1997-02-18
PCT/US1997/008101 WO1997043404A2 (en) 1996-05-13 1997-05-13 Ribozyme variants with improved catalytic activity under low magnesium conditions

Publications (1)

Publication Number Publication Date
AU3005697A true AU3005697A (en) 1997-12-05

Family

ID=27095188

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30056/97A Abandoned AU3005697A (en) 1996-05-13 1997-05-13 Ribozyme variants with improved catalytic activity under low magnesium conditions

Country Status (2)

Country Link
AU (1) AU3005697A (en)
WO (1) WO1997043404A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR020329A1 (en) * 1998-07-09 2002-05-08 Boehringer Ingelheim Pharma A SUBSTANCE, IN PARTICULAR A RIBOZIMA, IS ABLE TO INHIBIT THE PRESENILINE EXPRESSION 2, A RECOMBINATING MOLECULA OF DNA THAT CODIFY SUCH RIBOZIMA, A RECOMBINATING UNVECTOR THAT UNDERSTANDS THE CORRECTING CELL TO A RIBO BELLING ONE.
US9476089B2 (en) * 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof

Also Published As

Publication number Publication date
WO1997043404A2 (en) 1997-11-20
WO1997043404A3 (en) 1997-12-24

Similar Documents

Publication Publication Date Title
AU2384997A (en) Highly active double metal cyanide catalysts
GB9622284D0 (en) Improved catalyst
EP0964930A4 (en) Catalytic rna molecules
AU2751697A (en) Catalytic converter
AU4989397A (en) Seismic activity predictor
AU3132795A (en) Oligonucleotides with anti-mdr-1 gene activity
AU4298796A (en) An enzyme preparation with cellulytic activity
MXPA99001777A (en) Dihydropyrones with improved antiviral activity.
GR3036656T3 (en) 10-Aminoaliphatyl-dibenz(b,f)oxepins with antineurodegenarative activity
EP0787526A3 (en) Catalytic reaction rate enhancement at low temperatures
ZA977833B (en) N-substituted-2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylate inhibitory activity.
PL332641A1 (en) Catalysts
GB9619724D0 (en) Catalyst
AU2568697A (en) An enzyme with beta-1,3-glucanase activity
AU3005697A (en) Ribozyme variants with improved catalytic activity under low magnesium conditions
AU3702399A (en) Catalytically active structure
AU2215097A (en) Selected oligonucleotides with anti-cytomegalovirus activity
AU2801497A (en) Oligonucleotides with anti-epstein-barr virus activity
AU5775798A (en) Beta-galactosidase with reversibly inactive lactase activity
AU7846798A (en) Further anthraquinones with biological activity
AU4630697A (en) Improvements in catalytic processes
AU1437697A (en) An enzyme with xylanase activity
ZA957109B (en) Bound-in catalysts.
AU7846898A (en) Anthraquinones with biological activity
AU5941398A (en) High activity catalysts