AU2934399A - Transcription factors and their use - Google Patents

Transcription factors and their use

Info

Publication number
AU2934399A
AU2934399A AU29343/99A AU2934399A AU2934399A AU 2934399 A AU2934399 A AU 2934399A AU 29343/99 A AU29343/99 A AU 29343/99A AU 2934399 A AU2934399 A AU 2934399A AU 2934399 A AU2934399 A AU 2934399A
Authority
AU
Australia
Prior art keywords
transcription factors
domain
amino acid
leucine zipper
towards
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29343/99A
Inventor
Peter Angel
Peter Herrlich
Hans Van Dam
Alex Van Der Erb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Karlsruhe GmbH
Universiteit Leiden
Original Assignee
Forschungszentrum Karlsruhe GmbH
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Karlsruhe GmbH, Universiteit Leiden filed Critical Forschungszentrum Karlsruhe GmbH
Publication of AU2934399A publication Critical patent/AU2934399A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to transcription factors with a DNA binding domain consisting of a basic domain and an adjacent leucine zipper domain. The aim of the invention is to provide modified transcription factors whose binding behaviour towards each other and towards DNA sequences can be manipulated. To this end, at least one amino acid on the leucine zipper is replaced by a loaded amino acid.
AU29343/99A 1998-04-06 1999-03-18 Transcription factors and their use Abandoned AU2934399A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19815331 1998-04-06
DE19815331A DE19815331A1 (en) 1998-04-06 1998-04-06 Transcription factors and their use
PCT/EP1999/001805 WO1999051635A1 (en) 1998-04-06 1999-03-18 Transcription factors and their use

Publications (1)

Publication Number Publication Date
AU2934399A true AU2934399A (en) 1999-10-25

Family

ID=7863729

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29343/99A Abandoned AU2934399A (en) 1998-04-06 1999-03-18 Transcription factors and their use

Country Status (6)

Country Link
EP (1) EP1068233B1 (en)
JP (1) JP2002510708A (en)
AT (1) ATE328900T1 (en)
AU (1) AU2934399A (en)
DE (2) DE19815331A1 (en)
WO (1) WO1999051635A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1130096A1 (en) * 2000-03-03 2001-09-05 Institut de la Santé et de la Recherche Médicale Proliferation arrest trancription factor (PATF) and its use
US20030138440A1 (en) * 2001-07-19 2003-07-24 Fang Fang Multimeric proteins and methods of making and using same
AU2012207040B2 (en) * 2001-07-19 2014-06-26 Perlan Therapeutics, Inc. Multimeric proteins and methods of making and using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721340A (en) * 1994-11-28 1998-02-24 The Wistar Institute Of Anatomy & Biology p53 proteins with altered tetramerization domains
EP0854931A4 (en) * 1995-10-06 2002-02-13 Pence Inc Coiled-coil heterodimer methods and compositions for the detection and purification of expressed proteins

Also Published As

Publication number Publication date
JP2002510708A (en) 2002-04-09
DE19815331A1 (en) 1999-10-14
EP1068233B1 (en) 2006-06-07
WO1999051635A1 (en) 1999-10-14
ATE328900T1 (en) 2006-06-15
EP1068233A1 (en) 2001-01-17
DE59913524D1 (en) 2006-07-20

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase