AU2934399A - Transcription factors and their use - Google Patents
Transcription factors and their useInfo
- Publication number
- AU2934399A AU2934399A AU29343/99A AU2934399A AU2934399A AU 2934399 A AU2934399 A AU 2934399A AU 29343/99 A AU29343/99 A AU 29343/99A AU 2934399 A AU2934399 A AU 2934399A AU 2934399 A AU2934399 A AU 2934399A
- Authority
- AU
- Australia
- Prior art keywords
- transcription factors
- domain
- amino acid
- leucine zipper
- towards
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Saccharide Compounds (AREA)
Abstract
The invention relates to transcription factors with a DNA binding domain consisting of a basic domain and an adjacent leucine zipper domain. The aim of the invention is to provide modified transcription factors whose binding behaviour towards each other and towards DNA sequences can be manipulated. To this end, at least one amino acid on the leucine zipper is replaced by a loaded amino acid.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19815331A DE19815331A1 (en) | 1998-04-06 | 1998-04-06 | Transcription factors and their use |
DE19815331 | 1998-04-06 | ||
PCT/EP1999/001805 WO1999051635A1 (en) | 1998-04-06 | 1999-03-18 | Transcription factors and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2934399A true AU2934399A (en) | 1999-10-25 |
Family
ID=7863729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU29343/99A Abandoned AU2934399A (en) | 1998-04-06 | 1999-03-18 | Transcription factors and their use |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1068233B1 (en) |
JP (1) | JP2002510708A (en) |
AT (1) | ATE328900T1 (en) |
AU (1) | AU2934399A (en) |
DE (2) | DE19815331A1 (en) |
WO (1) | WO1999051635A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1130096A1 (en) * | 2000-03-03 | 2001-09-05 | Institut de la Santé et de la Recherche Médicale | Proliferation arrest trancription factor (PATF) and its use |
AU2012207040B2 (en) * | 2001-07-19 | 2014-06-26 | Perlan Therapeutics, Inc. | Multimeric proteins and methods of making and using same |
JP2005522192A (en) | 2001-07-19 | 2005-07-28 | パーラン セラピューティクス, インコーポレイテッド | Multimeric proteins and methods of making and using multimeric proteins |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
AU695679B2 (en) * | 1995-10-06 | 1998-08-20 | Pence, Inc. | Coiled-coil heterodimer methods and compositions for the detection and purification of expressed proteins |
-
1998
- 1998-04-06 DE DE19815331A patent/DE19815331A1/en not_active Withdrawn
-
1999
- 1999-03-18 DE DE59913524T patent/DE59913524D1/en not_active Expired - Lifetime
- 1999-03-18 JP JP2000542356A patent/JP2002510708A/en active Pending
- 1999-03-18 AU AU29343/99A patent/AU2934399A/en not_active Abandoned
- 1999-03-18 EP EP99910361A patent/EP1068233B1/en not_active Expired - Lifetime
- 1999-03-18 AT AT99910361T patent/ATE328900T1/en not_active IP Right Cessation
- 1999-03-18 WO PCT/EP1999/001805 patent/WO1999051635A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1068233A1 (en) | 2001-01-17 |
JP2002510708A (en) | 2002-04-09 |
DE19815331A1 (en) | 1999-10-14 |
EP1068233B1 (en) | 2006-06-07 |
WO1999051635A1 (en) | 1999-10-14 |
ATE328900T1 (en) | 2006-06-15 |
DE59913524D1 (en) | 2006-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |