AU2416395A - Method and device for detecting free IGFBP-1 - Google Patents

Method and device for detecting free IGFBP-1

Info

Publication number
AU2416395A
AU2416395A AU24163/95A AU2416395A AU2416395A AU 2416395 A AU2416395 A AU 2416395A AU 24163/95 A AU24163/95 A AU 24163/95A AU 2416395 A AU2416395 A AU 2416395A AU 2416395 A AU2416395 A AU 2416395A
Authority
AU
Australia
Prior art keywords
igfbp
igf
free
blood serum
fetal membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU24163/95A
Other versions
AU706284B2 (en
Inventor
Marina Boltovskaya
Boris Foux
Alexandr Konstantinov
Svetlana Nazimova
Nelli Starosvetskaya
Alexandr Stepanov
Evgeny Zaraisky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuks Boris
Original Assignee
Fuks Boris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22883079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2416395(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fuks Boris filed Critical Fuks Boris
Publication of AU2416395A publication Critical patent/AU2416395A/en
Application granted granted Critical
Publication of AU706284B2 publication Critical patent/AU706284B2/en
Assigned to BOLTOVSKAYA, MARINA, ZARAISKY, EVGENY, FUKS, BORIS, NAZIMOVA, SVETLANA, KONSTANTINOV, ALEXANDR, STAROSVETSKAYA, NELLI, STEPANOV, ALEXANDR reassignment BOLTOVSKAYA, MARINA Request to Amend Deed and Register Assignors: BOLTOVSKAYA, MARINA, FOUX, BORIS, KONSTANTINOV, ALEXANDR, NAZIMOVA, SVETLANA, STAROSVETSKAYA, NELLI, STEPANOV, ALEXANDR, ZARAISKI, EVGUENY
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G01N33/54389—Immunochromatographic test strips based on lateral flow with bidirectional or multidirectional lateral flow, e.g. wherein the sample flows from a single, common sample application point into multiple strips, lanes or zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/969—Multiple layering of reactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Interface Circuits In Exchanges (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
  • Maintenance And Management Of Digital Transmission (AREA)

Abstract

A method and device for detecting fetal membrane rupture by detecting only that insulin-like growth-factor-binding protein 1 (IGFBP-1) which is free of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) are disclosed. The method is based on the fact that the concentration of free IGFBP-1 in the blood serum is about 10 times lower than that of the IGFBP-1 bound to IGF-1 and IGF-2, while in the amniotic liquid which is contained in the amnion has more than 1000 times the concentration of free IGFBP-1 than the blood serum. Therefore, when even a small amount of amniotic liquid is contained in the vaginal secretion sample, this is clear evidence of the rupture of the fetal membrane having taken place. The method and the device make it possible to diagnose fetal membrane rupture with an extremely high accuracy. Because of the low concentration of the IGFBP-1 in the blood, the admixture of the blood serum to the sample does not affect the results of the test. The device comprises a one-pad-two-strips test kit which may be used to detect free IGFBP-1 in a range of concentrations from 5 ng/ml to 250 mu g/ml.
AU24163/95A 1994-04-28 1995-04-27 Method and device for detecting free IGFBP-1 Ceased AU706284B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/234,851 US5597700A (en) 1994-04-28 1994-04-28 Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method
US08/234851 1994-04-28
PCT/IB1995/000364 WO1995030150A1 (en) 1994-04-28 1995-04-27 Method for detecting free igfbp-1

Publications (2)

Publication Number Publication Date
AU2416395A true AU2416395A (en) 1995-11-29
AU706284B2 AU706284B2 (en) 1999-06-10

Family

ID=22883079

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24163/95A Ceased AU706284B2 (en) 1994-04-28 1995-04-27 Method and device for detecting free IGFBP-1

Country Status (8)

Country Link
US (4) US5597700A (en)
EP (1) EP0755515B1 (en)
JP (1) JP2001501723A (en)
AT (1) ATE186403T1 (en)
AU (1) AU706284B2 (en)
CA (1) CA2189050A1 (en)
DE (1) DE69513160D1 (en)
WO (1) WO1995030150A1 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94181C (en) * 1992-06-29 1995-07-25 Medix Biochemica Ab Oy Diagnostic method for predicting the time of delivery and reagent kit used for it
US5712103A (en) * 1995-02-13 1998-01-27 Regents Of The University Of California Diagnostic assay for the prediction of preeclampsia
US20080064044A9 (en) * 1995-05-23 2008-03-13 Nelson Randall W Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
US6066464A (en) * 1996-12-10 2000-05-23 Diagnostic Systems Laboratories, Inc. Immunoassay of IGF family of peptides, their binding proteins and related molecules in dried whole blood filter paper spots
US6403764B1 (en) * 1999-01-06 2002-06-11 Genentech, Inc. Insulin-like growth factor-1 protein variants
WO1999002985A1 (en) * 1997-07-11 1999-01-21 Rosengreen Lea T Wearable amniotic fluid detection device
US6394952B1 (en) * 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
US6126597A (en) * 1998-07-22 2000-10-03 Smith; Ramada S. System for identifying premature rupture of membrane during pregnancy
AU762047B2 (en) * 1999-01-06 2003-06-19 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
US6136549A (en) * 1999-10-15 2000-10-24 Feistel; Christopher C. systems and methods for performing magnetic chromatography assays
WO2001072323A2 (en) * 2000-03-24 2001-10-04 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
WO2001087323A2 (en) 2000-05-16 2001-11-22 Genentech, Inc. Method for treating cartilage disorders
US7071160B2 (en) * 2000-06-15 2006-07-04 Kyowa Hakko Kogyo Co., Ltd. Insulin-like growth factor-binding protein
US7790690B2 (en) 2000-10-11 2010-09-07 U.S. Department Of Veterans Affairs Glucose sensitive regulator of insulin transcription
KR100425525B1 (en) * 2000-11-21 2004-03-30 재단법인서울대학교산학협력재단 Diagnostic agents for detecting premature birth, fetal infection and fetal damage and diagnostic kit containing the same
US6575102B2 (en) * 2001-02-09 2003-06-10 Trn Business Trust Temperature controlled railway car
WO2002064633A1 (en) * 2001-02-14 2002-08-22 Victor Voroteliak Monoclonal antibody against an unknown antigen from amniotic flu id and its method of preparation
US20040002168A1 (en) * 2002-06-13 2004-01-01 Neuropro Technologies, Inc. Apparatus and methods for detecting cerebrospinal fluid
EP2204654B1 (en) 2002-08-13 2012-12-12 N-Dia, Inc. Use of devices and methods for detecting amniotic fluid in vaginal secretions
EP1936376B1 (en) 2003-02-06 2012-04-11 Hologic Inc. Screening and treatment methods for prevention of preterm delivery
JP2007535895A (en) * 2003-05-01 2007-12-13 イムクローン システムズ インコーポレイティド Fully human antibody against human insulin-like growth factor-1 receptor
US20050131287A1 (en) * 2003-12-16 2005-06-16 Kimberly-Clark Worldwide, Inc. Detection of premature rupture of the amniotic membrane
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
EP1778874B1 (en) 2004-07-30 2011-11-23 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for cervical cancer
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US7189522B2 (en) * 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
KR20080047529A (en) * 2005-06-17 2008-05-29 임클론 시스템즈 인코포레이티드 Receptor antagonists for treatment of metastatic bone cancer
US20070020699A1 (en) * 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
EP1937709A4 (en) * 2005-09-15 2011-06-08 Swiss Asian Property Ltd A marker for prolonged rupture of membranes
AU2007212447B2 (en) * 2006-02-03 2013-02-21 Imclone Llc IGF-IR antagonists as adjuvants for treatment of prostate cancer
CN101275954B (en) * 2008-05-09 2012-01-04 丁克祥 Breast cancer early warning chip for easily rapid measuring human I type thymidine kinase gene protein
US20120156766A1 (en) * 2009-06-24 2012-06-21 Akiko Shiratori Sample analyzing chip and measurement system using same
FR2960974B1 (en) * 2010-06-03 2016-12-30 Biosynex METHOD OF DETECTING BREAKAGE OF MEMBRANES
US10338065B2 (en) 2010-09-01 2019-07-02 Clinical Innovations, Llc Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
US11555816B2 (en) 2010-09-01 2023-01-17 Clinical Innovations, Llc Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
US8765487B2 (en) 2010-09-01 2014-07-01 Clinical Innovations Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes
WO2014066568A1 (en) 2012-10-24 2014-05-01 Winthrop-University Hospital Non-invasive biomarker to identify subjects at risk of preterm delivery
EP2941644B1 (en) 2013-01-02 2019-09-11 Qiagen Sciences, LLC Methods for predicting time-to-delivery in pregnant women
WO2015047994A2 (en) * 2013-09-24 2015-04-02 The Board Of Regentsl Of The University Of Texas System A novel hormone that promotes bone resorption and uses thereof
KR20160140186A (en) * 2015-05-29 2016-12-07 삼성전자주식회사 Strip for analysis, apparaturs and system using the strip for analysis
US10935555B2 (en) 2016-12-22 2021-03-02 Qiagen Sciences, Llc Determining candidate for induction of labor
US10656164B2 (en) 2016-12-22 2020-05-19 Qiagen Sciences, Llc Screening asymptomatic pregnant woman for preterm birth
US10458974B2 (en) * 2017-06-09 2019-10-29 Optimum Imaging Diagnostics LLC Universal testing system for quantitative analysis
KR20200109293A (en) 2017-09-13 2020-09-22 프로제너티, 인크. Preeclampsia biomarkers and related systems and methods
CN109521207A (en) * 2018-12-28 2019-03-26 广州菲康生物技术有限公司 A kind of IGF-1 fluorescence immune chromatography detection kit
WO2021005604A1 (en) 2019-07-11 2021-01-14 Opko Biologics Ltd. Long-acting igf-1 or igf-1 variants and methods of producing same
EP4070113A4 (en) 2019-12-04 2023-12-20 Biora Therapeutics, Inc. Assessment of preeclampsia using assays for free and dissociated placental growth factor
WO2023049834A1 (en) * 2021-09-24 2023-03-30 The Trustees Of Indiana University Composition and method to treat cachexia

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235601A (en) * 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
DE3445816C1 (en) * 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flat diagnostic agent
US4743542A (en) * 1985-04-11 1988-05-10 Ortho Diagnostic Method for forestalling the hook effect in a multi-ligand immunoassay system
ATE195022T1 (en) * 1987-04-27 2000-08-15 Unilever Nv SPECIFIC BINDING TESTING METHODS
US4788138A (en) * 1987-04-30 1988-11-29 Beckman Instruments, Inc. Method to achieve a linear standard curve in a sandwich immunoassay
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4981786A (en) * 1987-09-04 1991-01-01 Syntex (U.S.A.) Inc. Multiple port assay device
US5006474A (en) * 1987-12-16 1991-04-09 Disease Detection International Inc. Bi-directional lateral chromatographic test device
US5075078A (en) * 1989-10-05 1991-12-24 Abbott Laboratories Self-performing immunochromatographic device
US5252496A (en) * 1989-12-18 1993-10-12 Princeton Biomeditech Corporation Carbon black immunochemical label
FI86777C (en) * 1990-12-31 1992-10-12 Medix Biochemica Ab Oy FOERFARANDE FOER DIAGNOSTICERING AV BRISTNINGEN AV FOSTERHINNORNA SAMT REAGENSFOERPACKNING FOER ANVAENDNING DAERVID
FI94181C (en) * 1992-06-29 1995-07-25 Medix Biochemica Ab Oy Diagnostic method for predicting the time of delivery and reagent kit used for it
US5308775A (en) * 1992-09-15 1994-05-03 Abbott Laboratories Assay devices for concurrently detecting an analyte and confirming the test result
GB9225241D0 (en) * 1992-12-02 1993-01-20 Johnson & Son Inc S C A dispensing closure for containers
EP0680607A4 (en) * 1993-01-22 1997-06-04 Adeza Biomedical Corp Assay method to rule out rupture of membranes in women at risk for imminent delivery.
JPH09509249A (en) * 1993-12-20 1997-09-16 モハン，サブブラマン Method for removing binding protein from ligand
US5712103A (en) * 1995-02-13 1998-01-27 Regents Of The University Of California Diagnostic assay for the prediction of preeclampsia

Also Published As

Publication number Publication date
US5968758A (en) 1999-10-19
US5597700A (en) 1997-01-28
EP0755515A4 (en) 1997-03-19
US5891722A (en) 1999-04-06
ATE186403T1 (en) 1999-11-15
EP0755515A1 (en) 1997-01-29
US5877029A (en) 1999-03-02
JP2001501723A (en) 2001-02-06
AU706284B2 (en) 1999-06-10
DE69513160D1 (en) 1999-12-09
CA2189050A1 (en) 1995-11-09
EP0755515B1 (en) 1999-11-03
WO1995030150A1 (en) 1995-11-09

Similar Documents

Publication Publication Date Title
AU2416395A (en) Method and device for detecting free IGFBP-1
Bos et al. 3, 3′, 5, 5′-Tetramethylbenzidine as an Ames test negative chromogen for horse-radish peroxidase in enzyme-immunoassay
Langford et al. Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy.
Gautray et al. Presence of immunoassayable β-endorphin in human amniotic fluid: Elevation in cases of fetal distress
AU8247291A (en) Protein precipitation reagent
AU8866291A (en) Assay for glycated blood proteins
CA2055430A1 (en) Glycosylated Haemoglobin Assay
WO1995030150B1 (en) Method for detecting free igfbp-1
NO930770L (en) IMMUNOLOGICAL PROCEDURE FOR DETERMINING A HEMOGLOBIN DERIVATIVE
CA2139309A1 (en) Diagnostic method for determining the susceptibility to delivery and reagent kit for use therefor
McGaughey A comparison of the fluids from small and large ovarian follicles of the pig
EP0842422A1 (en) Synthetic oral fluid standard
Gaucherand et al. Diagnosis of premature rupture of the membranes by the identification of alpha‐feto‐protein in vaginal secretions
Wakim et al. Triiodothyronine receptors in porcine granulosa cells
US4123510A (en) Method for the determination of gonadotropins
CA2174438A1 (en) Cleaning solution for automatic analyzers
Bruun et al. Thyroid function during pregnancy with special reference to hydatidiform mole and hyperemesis
HAMILTON et al. Dialysis cell for rapid quantitative analytical determination of diffusible components in blood plasma
Kawasaki et al. Protein analyses and reagents: microscale assay of calcium-binding activity of proteins and peptides using a nitrocellulose membrane
Dallaire et al. Feto‐maternal amino acid metabolism
Subryan et al. Measurement of serum ionized calcium with the ion-exchange electrode
US20020055182A1 (en) Method for determining the fertility of mammals, especially humans
Jarry et al. Angiotensin II/III and substance P in human follicular fluid obtained during IVF: relation of the peptide content with follicular size
Subramanian et al. Human follicular fluid: prolactin is biologically active and ovum fertilization correlates with estradiol concentration
CN114112594A (en) Insulin-like growth factor-1 pretreatment reagent

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired