AU2023250874A1 - Amorphous and crystalline forms of mci-1 antagonists - Google Patents
Amorphous and crystalline forms of mci-1 antagonists Download PDFInfo
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- AU2023250874A1 AU2023250874A1 AU2023250874A AU2023250874A AU2023250874A1 AU 2023250874 A1 AU2023250874 A1 AU 2023250874A1 AU 2023250874 A AU2023250874 A AU 2023250874A AU 2023250874 A AU2023250874 A AU 2023250874A AU 2023250874 A1 AU2023250874 A1 AU 2023250874A1
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- 238000013265 extended release Methods 0.000 description 1
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- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
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- 231100000722 genetic damage Toxicity 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940049654 glyceryl behenate Drugs 0.000 description 1
- FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 description 1
- 229940046813 glyceryl palmitostearate Drugs 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 description 1
- 229960003988 indigo carmine Drugs 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- 238000000386 microscopy Methods 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 238000001565 modulated differential scanning calorimetry Methods 0.000 description 1
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 125000000914 phenoxymethylpenicillanyl group Chemical group CC1(S[C@H]2N([C@H]1C(=O)*)C([C@H]2NC(COC2=CC=CC=C2)=O)=O)C 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263327656P | 2022-04-05 | 2022-04-05 | |
| US63/327,656 | 2022-04-05 | ||
| PCT/US2023/017505 WO2023196361A1 (en) | 2022-04-05 | 2023-04-05 | Amorphous and crystalline forms of mci-1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2023250874A1 true AU2023250874A1 (en) | 2024-10-10 |
Family
ID=86386948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023250874A Pending AU2023250874A1 (en) | 2022-04-05 | 2023-04-05 | Amorphous and crystalline forms of mci-1 antagonists |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240140966A1 (https=) |
| EP (1) | EP4504738A1 (https=) |
| JP (1) | JP2025511331A (https=) |
| AU (1) | AU2023250874A1 (https=) |
| CA (1) | CA3255077A1 (https=) |
| MX (1) | MX2024012195A (https=) |
| TW (1) | TW202404982A (https=) |
| UY (1) | UY40218A (https=) |
| WO (1) | WO2023196361A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4519271A1 (en) | 2022-05-04 | 2025-03-12 | Gilead Sciences, Inc. | Salts and polymorphs of certain mcl-1 inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3474B1 (ar) | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| KR20230113577A (ko) * | 2020-11-25 | 2023-07-31 | 암젠 인크 | 알데히드의 거울상이성질체 선택적 알케닐화 |
-
2023
- 2023-04-05 WO PCT/US2023/017505 patent/WO2023196361A1/en not_active Ceased
- 2023-04-05 AU AU2023250874A patent/AU2023250874A1/en active Pending
- 2023-04-05 EP EP23724439.7A patent/EP4504738A1/en active Pending
- 2023-04-05 JP JP2024558382A patent/JP2025511331A/ja active Pending
- 2023-04-05 CA CA3255077A patent/CA3255077A1/en active Pending
- 2023-04-05 US US18/296,211 patent/US20240140966A1/en active Pending
- 2023-04-06 TW TW112112761A patent/TW202404982A/zh unknown
- 2023-04-10 UY UY0001040218A patent/UY40218A/es unknown
-
2024
- 2024-10-02 MX MX2024012195A patent/MX2024012195A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20240140966A1 (en) | 2024-05-02 |
| CA3255077A1 (en) | 2023-10-12 |
| TW202404982A (zh) | 2024-02-01 |
| WO2023196361A1 (en) | 2023-10-12 |
| MX2024012195A (es) | 2024-11-08 |
| EP4504738A1 (en) | 2025-02-12 |
| JP2025511331A (ja) | 2025-04-15 |
| UY40218A (es) | 2023-10-13 |
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