AU2023216406A1 - Theragnostic folate conjugates - Google Patents

Theragnostic folate conjugates Download PDF

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Publication number
AU2023216406A1
AU2023216406A1 AU2023216406A AU2023216406A AU2023216406A1 AU 2023216406 A1 AU2023216406 A1 AU 2023216406A1 AU 2023216406 A AU2023216406 A AU 2023216406A AU 2023216406 A AU2023216406 A AU 2023216406A AU 2023216406 A1 AU2023216406 A1 AU 2023216406A1
Authority
AU
Australia
Prior art keywords
compound according
compound
radiometal
folate
dota
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2023216406A
Other languages
English (en)
Inventor
Anna Elisabeth BECKER
Sara Dorina BUSSLINGER
Luisa Maria DEBERLE
Viola Groehn
Rudolf Moser
Cristina Magdalena Mueller
Marie-Luise RENZ
Roger Schibli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2023216406A1 publication Critical patent/AU2023216406A1/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0402Organic compounds carboxylic acid carriers, fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2023216406A 2022-02-01 2023-01-30 Theragnostic folate conjugates Pending AU2023216406A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22154652 2022-02-01
EP22154652.6 2022-02-01
PCT/EP2023/052117 WO2023148116A1 (en) 2022-02-01 2023-01-30 Theragnostic folate conjugates

Publications (1)

Publication Number Publication Date
AU2023216406A1 true AU2023216406A1 (en) 2024-09-19

Family

ID=80118841

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2023216406A Pending AU2023216406A1 (en) 2022-02-01 2023-01-30 Theragnostic folate conjugates

Country Status (9)

Country Link
US (1) US20250127938A1 (https=)
EP (1) EP4472677A1 (https=)
JP (1) JP2025504027A (https=)
KR (1) KR20240146013A (https=)
CN (1) CN118647412A (https=)
AU (1) AU2023216406A1 (https=)
CA (1) CA3243584A1 (https=)
IL (1) IL314508A (https=)
WO (1) WO2023148116A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025227100A2 (en) * 2024-04-26 2025-10-30 Purdue Research Foundation Targeted delivery of therapeutic agent to retinal pigment epithelium in treatment of ocular diseases

Also Published As

Publication number Publication date
CN118647412A (zh) 2024-09-13
WO2023148116A1 (en) 2023-08-10
CA3243584A1 (en) 2023-08-10
US20250127938A1 (en) 2025-04-24
KR20240146013A (ko) 2024-10-07
EP4472677A1 (en) 2024-12-11
IL314508A (en) 2024-09-01
JP2025504027A (ja) 2025-02-06

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