AU2023206609A1 - Method of producing vdelta1+ t cells - Google Patents

Method of producing vdelta1+ t cells Download PDF

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Publication number
AU2023206609A1
AU2023206609A1 AU2023206609A AU2023206609A AU2023206609A1 AU 2023206609 A1 AU2023206609 A1 AU 2023206609A1 AU 2023206609 A AU2023206609 A AU 2023206609A AU 2023206609 A AU2023206609 A AU 2023206609A AU 2023206609 A1 AU2023206609 A1 AU 2023206609A1
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Australia
Prior art keywords
cells
cell
cdla
human
express
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Pending
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AU2023206609A
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English (en)
Inventor
Juan ALCAIN SÁNCHEZ
Víctor Manuel DÍAZ CORTÉS
Patricia FUENTES VILLAREJO
María Jesús GARCÍA LEÓN
Laura GARCÍA PÉREZ
María Luisa TORIBIO GARCÍA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Onechain Immunotherapeutics Sl
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Onechain Immunotherapeutics Sl
Consejo Superior de Investigaciones Cientificas CSIC
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Application filed by Onechain Immunotherapeutics Sl, Consejo Superior de Investigaciones Cientificas CSIC filed Critical Onechain Immunotherapeutics Sl
Publication of AU2023206609A1 publication Critical patent/AU2023206609A1/en
Pending legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4702—Regulators; Modulating activity
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2321—Interleukin-21 (IL-21)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
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    • C12N2510/00—Genetically modified cells

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2023206609A 2022-01-12 2023-01-12 Method of producing vdelta1+ t cells Pending AU2023206609A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22382013.5 2022-01-12
EP22382013.5A EP4212618A1 (en) 2022-01-12 2022-01-12 Method of producing vdelta1+ t cells
PCT/EP2023/050665 WO2023135225A1 (en) 2022-01-12 2023-01-12 Method of producing vdelta1+ t cells

Publications (1)

Publication Number Publication Date
AU2023206609A1 true AU2023206609A1 (en) 2024-07-04

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ID=79601554

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AU2023206609A Pending AU2023206609A1 (en) 2022-01-12 2023-01-12 Method of producing vdelta1+ t cells

Country Status (10)

Country Link
US (1) US20250297218A1 (https=)
EP (2) EP4212618A1 (https=)
JP (1) JP2025502150A (https=)
KR (1) KR20240130726A (https=)
CN (1) CN118871573A (https=)
AU (1) AU2023206609A1 (https=)
CA (1) CA3246462A1 (https=)
IL (1) IL314081A (https=)
MX (1) MX2024008712A (https=)
WO (1) WO2023135225A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120924492B (zh) * 2025-10-15 2026-03-03 瑞因细胞工程科技(广州)有限公司 一种脐血来源γδT细胞的体外诱导组合物及培养方法

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Publication number Publication date
WO2023135225A1 (en) 2023-07-20
EP4212618A1 (en) 2023-07-19
CA3246462A1 (en) 2023-07-20
KR20240130726A (ko) 2024-08-29
EP4463541A1 (en) 2024-11-20
MX2024008712A (es) 2024-07-25
JP2025502150A (ja) 2025-01-24
US20250297218A1 (en) 2025-09-25
CN118871573A (zh) 2024-10-29
IL314081A (en) 2024-09-01

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