AU2022449781A1 - Anti-cd7 nanobody, and derivative thereof and use thereof in tumor therapy - Google Patents

Anti-cd7 nanobody, and derivative thereof and use thereof in tumor therapy Download PDF

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Publication number
AU2022449781A1
AU2022449781A1 AU2022449781A AU2022449781A AU2022449781A1 AU 2022449781 A1 AU2022449781 A1 AU 2022449781A1 AU 2022449781 A AU2022449781 A AU 2022449781A AU 2022449781 A AU2022449781 A AU 2022449781A AU 2022449781 A1 AU2022449781 A1 AU 2022449781A1
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seq
chimeric antigen
antigen receptor
nanobody
tumor
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Jianqiang Li
Lin Wang
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Hebei Senlang Biotechnology Co Ltd
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Hebei Senlang Biotechnology Co Ltd
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CN115806618B (zh) * 2022-03-30 2025-11-11 河北森朗生物科技有限公司 一种抗cd7的纳米抗体vhh12及其相关产品、方法和用途
CN115991776B (zh) * 2022-10-26 2023-08-01 上海驯鹿生物技术有限公司 一种靶向cd7的全人源抗体及其应用
CN117362437A (zh) * 2023-07-21 2024-01-09 南京蓬勃生物科技有限公司 靶向人源cd7的抗体或其抗原结合片段及其应用
CN116970082B (zh) * 2023-09-22 2023-12-12 汇智生物技术(苏州)有限公司 人源cd7单克隆抗体及其制备方法和应用
CN119285779B (zh) * 2023-11-20 2026-04-10 上海百英生物科技股份有限公司 一种抗cd28纳米抗体及其制备方法与应用
CN117946272B (zh) * 2023-12-29 2026-06-30 华道(上海)生物医药股份有限公司 一种靶向cd7的抗体及其应用
CN117843787B (zh) * 2023-12-29 2026-03-31 华道(上海)生物医药股份有限公司 一种抗cd7抗体及其应用
CN118580353B (zh) * 2024-06-12 2025-03-28 深圳厚朴医疗健康科技有限公司 一种靶向b7-h3的单域抗体、嵌合抗原受体分子、嵌合抗原受体细胞及其在制备治疗鼻咽癌的药物中的应用
WO2026007830A1 (zh) * 2024-07-03 2026-01-08 深圳市济因生物科技有限公司 一种靶向cd7的纳米抗体及其应用
CN119215156B (zh) * 2024-12-05 2025-05-13 山东省成体细胞产业技术研究院有限公司 一种体内生成car-t的纳米颗粒及其应用
CN119978135B (zh) * 2025-01-02 2025-11-21 生物岛实验室 Sumo标签蛋白的特异性抗体及其制备方法与应用
CN122344265A (zh) * 2026-06-01 2026-07-07 天宜康医药(上海)有限公司 Cd7和cd3双靶向融合蛋白及其应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
WO1993017668A1 (en) 1992-03-12 1993-09-16 Alkermes Controlled Therapeutics, Inc. Controlled release acth containing microspheres
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
CN104004095B (zh) * 2014-06-04 2016-11-23 博生吉医药科技(苏州)有限公司 一种cd7纳米抗体、其编码序列及应用
WO2016040441A1 (en) * 2014-09-09 2016-03-17 Unum Therapeutics Chimeric receptors and uses thereof in immune therapy
CA2977106A1 (en) * 2015-02-27 2016-09-01 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
MA51428A (fr) * 2017-12-22 2020-11-04 Bluebird Bio Inc Récepteur d'antigène chimérique multivalent
CN109652379B (zh) * 2018-12-29 2022-08-16 博生吉医药科技(苏州)有限公司 Cd7嵌合抗原受体修饰的nk-92mi细胞及其应用
CN110760007B (zh) * 2019-11-21 2022-08-26 博生吉医药科技(苏州)有限公司 Cd7-car-t细胞及其制备和应用
CN115786271B (zh) * 2021-01-12 2025-07-22 上海雅科生物科技有限公司 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用
CN113402619B (zh) * 2021-06-30 2022-03-22 徐州医科大学 一种靶向B7H3共表达IL-21的全人源嵌合抗原受体、iNKT细胞及其用途
CN115806618B (zh) * 2022-03-30 2025-11-11 河北森朗生物科技有限公司 一种抗cd7的纳米抗体vhh12及其相关产品、方法和用途

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