AU2022402987A1 - Antisense inhibitors of mir17hg pre-rna as therapeutic agents in cancer - Google Patents
Antisense inhibitors of mir17hg pre-rna as therapeutic agents in cancer Download PDFInfo
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- AU2022402987A1 AU2022402987A1 AU2022402987A AU2022402987A AU2022402987A1 AU 2022402987 A1 AU2022402987 A1 AU 2022402987A1 AU 2022402987 A AU2022402987 A AU 2022402987A AU 2022402987 A AU2022402987 A AU 2022402987A AU 2022402987 A1 AU2022402987 A1 AU 2022402987A1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
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- A61K33/24—Heavy metals; Compounds thereof
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2310/32—Chemical structure of the sugar
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- C12N2310/32—Chemical structure of the sugar
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- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/351—Conjugate
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- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Biotechnology (AREA)
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- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163284527P | 2021-11-30 | 2021-11-30 | |
| US63/284,527 | 2021-11-30 | ||
| PCT/US2022/080563 WO2023102377A2 (en) | 2021-11-30 | 2022-11-29 | Antisense inhibitors of mir17hg pre-rna as therapeutic agents in cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022402987A1 true AU2022402987A1 (en) | 2024-05-30 |
Family
ID=86613147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022402987A Pending AU2022402987A1 (en) | 2021-11-30 | 2022-11-29 | Antisense inhibitors of mir17hg pre-rna as therapeutic agents in cancer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240352462A1 (https=) |
| EP (1) | EP4441227A2 (https=) |
| JP (1) | JP2024543952A (https=) |
| KR (1) | KR20240112333A (https=) |
| CN (1) | CN118339292A (https=) |
| AU (1) | AU2022402987A1 (https=) |
| CA (1) | CA3238432A1 (https=) |
| WO (1) | WO2023102377A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117384903A (zh) * | 2023-10-23 | 2024-01-12 | 中国农业科学院兰州畜牧与兽药研究所 | 一种牦牛Lnc4047基因及其应用 |
| CN120789090B (zh) * | 2025-09-04 | 2025-11-28 | 核工业总医院 | U2surp在制备弥漫大b细胞淋巴瘤治疗药物中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1939286A4 (en) * | 2005-07-29 | 2009-05-20 | Kyowa Hakko Kirin Co Ltd | NEW PEPTIDE |
| EP3388068A1 (en) * | 2011-06-21 | 2018-10-17 | Alnylam Pharmaceuticals, Inc. | Composition and methods for inhibition of expression of protein c (proc) genes |
| US9862943B1 (en) * | 2013-06-27 | 2018-01-09 | California Institute Of Technology | Long noncoding RNAs and cell reprogramming and differentiation |
| EP3230454A1 (en) * | 2014-12-09 | 2017-10-18 | Pierfrancesco Tassone | Inhibitors of mir-17-92 cluster for anti-tumor activity in multiple myeloma and other malignancies |
-
2022
- 2022-11-29 JP JP2024532316A patent/JP2024543952A/ja active Pending
- 2022-11-29 CN CN202280079655.5A patent/CN118339292A/zh active Pending
- 2022-11-29 US US18/712,843 patent/US20240352462A1/en active Pending
- 2022-11-29 WO PCT/US2022/080563 patent/WO2023102377A2/en not_active Ceased
- 2022-11-29 AU AU2022402987A patent/AU2022402987A1/en active Pending
- 2022-11-29 EP EP22902336.1A patent/EP4441227A2/en active Pending
- 2022-11-29 KR KR1020247021295A patent/KR20240112333A/ko active Pending
- 2022-11-29 CA CA3238432A patent/CA3238432A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023102377A3 (en) | 2023-07-27 |
| EP4441227A2 (en) | 2024-10-09 |
| JP2024543952A (ja) | 2024-11-26 |
| US20240352462A1 (en) | 2024-10-24 |
| CN118339292A (zh) | 2024-07-12 |
| KR20240112333A (ko) | 2024-07-18 |
| WO2023102377A2 (en) | 2023-06-08 |
| CA3238432A1 (en) | 2023-06-08 |
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