AU2022374050A1 - Heterocyclic compounds for use in the treatment of cancer - Google Patents

Heterocyclic compounds for use in the treatment of cancer Download PDF

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Publication number
AU2022374050A1
AU2022374050A1 AU2022374050A AU2022374050A AU2022374050A1 AU 2022374050 A1 AU2022374050 A1 AU 2022374050A1 AU 2022374050 A AU2022374050 A AU 2022374050A AU 2022374050 A AU2022374050 A AU 2022374050A AU 2022374050 A1 AU2022374050 A1 AU 2022374050A1
Authority
AU
Australia
Prior art keywords
compound
compounds
agents
formula
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022374050A
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English (en)
Inventor
Owen Davis
Harry Finch
Robert Heald
Sam MANN
Martin Stockley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artios Pharma Ltd
Original Assignee
Artios Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artios Pharma Ltd filed Critical Artios Pharma Ltd
Publication of AU2022374050A1 publication Critical patent/AU2022374050A1/en
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2022374050A 2021-10-21 2022-10-21 Heterocyclic compounds for use in the treatment of cancer Pending AU2022374050A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2115156.8 2021-10-21
GBGB2115156.8A GB202115156D0 (en) 2021-10-21 2021-10-21 Novel compounds
PCT/GB2022/052690 WO2023067356A1 (en) 2021-10-21 2022-10-21 Heterocyclic compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
AU2022374050A1 true AU2022374050A1 (en) 2024-05-02

Family

ID=78805918

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022374050A Pending AU2022374050A1 (en) 2021-10-21 2022-10-21 Heterocyclic compounds for use in the treatment of cancer

Country Status (24)

Country Link
US (1) US20240425511A1 (https=)
EP (2) EP4419526B1 (https=)
JP (2) JP2024539132A (https=)
KR (1) KR20240099274A (https=)
CN (2) CN119053600A (https=)
AR (1) AR127431A1 (https=)
AU (1) AU2022374050A1 (https=)
CA (1) CA3233255A1 (https=)
DK (1) DK4419526T3 (https=)
ES (1) ES3008687T3 (https=)
FI (1) FI4419526T3 (https=)
GB (1) GB202115156D0 (https=)
HR (1) HRP20250334T1 (https=)
HU (1) HUE070568T2 (https=)
IL (1) IL311922A (https=)
LT (1) LT4419526T (https=)
MX (1) MX2024004874A (https=)
PL (1) PL4419526T3 (https=)
PT (1) PT4419526T (https=)
RS (1) RS66620B1 (https=)
SI (1) SI4419526T1 (https=)
SM (1) SMT202500123T1 (https=)
TW (1) TW202334150A (https=)
WO (2) WO2023067355A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025077896A1 (zh) * 2023-10-12 2025-04-17 上海湃隆生物科技有限公司 一种DNA聚合酶theta抑制剂及其应用
CN118084767B (zh) * 2024-04-02 2025-06-17 康龙化成手性医药技术(宁波)有限公司 一种外型-6-氟甲基-3-氮杂双环[3,1,0]己烷盐酸盐及其衍生物的合成方法
WO2025214463A1 (zh) * 2024-04-13 2025-10-16 正大天晴药业集团股份有限公司 含有三并环结构的化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017062754A1 (en) 2015-10-07 2017-04-13 New York University Compositions and methods for enhancing crispr activity by polq inhibition
US12358886B2 (en) * 2019-08-09 2025-07-15 Artios Pharma Limited Heterocyclic compounds for use in the treatment of cancer

Also Published As

Publication number Publication date
PL4419526T3 (pl) 2025-04-22
SMT202500123T1 (it) 2025-05-12
LT4419526T (lt) 2025-03-25
EP4419527A1 (en) 2024-08-28
HRP20250334T1 (hr) 2025-06-06
US20240425511A1 (en) 2024-12-26
JP2024542949A (ja) 2024-11-19
DK4419526T3 (da) 2025-02-17
EP4419526A1 (en) 2024-08-28
ES3008687T3 (en) 2025-03-24
FI4419526T3 (fi) 2025-02-13
CA3233255A1 (en) 2023-04-27
PT4419526T (pt) 2025-02-03
RS66620B1 (sr) 2025-04-30
WO2023067355A1 (en) 2023-04-27
EP4419526B1 (en) 2024-12-25
CN119053600A (zh) 2024-11-29
IL311922A (en) 2024-06-01
JP2024539132A (ja) 2024-10-28
CN118234728A (zh) 2024-06-21
KR20240099274A (ko) 2024-06-28
GB202115156D0 (en) 2021-12-08
WO2023067356A1 (en) 2023-04-27
SI4419526T1 (sl) 2025-05-30
AR127431A1 (es) 2024-01-24
HUE070568T2 (hu) 2025-06-28
TW202334150A (zh) 2023-09-01
MX2024004874A (es) 2024-05-06

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