AU2022367222A1 - Pyrrolo[2,1-f][1,2,4]triazines derivatives as inhibitors of dyrk1a - Google Patents
Pyrrolo[2,1-f][1,2,4]triazines derivatives as inhibitors of dyrk1a Download PDFInfo
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- AU2022367222A1 AU2022367222A1 AU2022367222A AU2022367222A AU2022367222A1 AU 2022367222 A1 AU2022367222 A1 AU 2022367222A1 AU 2022367222 A AU2022367222 A AU 2022367222A AU 2022367222 A AU2022367222 A AU 2022367222A AU 2022367222 A1 AU2022367222 A1 AU 2022367222A1
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- triazin
- pyrrolo
- amine
- imidazo
- methyl
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- C—CHEMISTRY; METALLURGY
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- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Applications Claiming Priority (5)
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| US202163254733P | 2021-10-12 | 2021-10-12 | |
| US63/254,733 | 2021-10-12 | ||
| US202263347757P | 2022-06-01 | 2022-06-01 | |
| US63/347,757 | 2022-06-01 | ||
| PCT/US2022/046416 WO2023064366A1 (en) | 2021-10-12 | 2022-10-12 | Pyrrolo[2,1-f][1,2,4]triazines derivatives as inhibitors of dyrk1a |
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| AU2022367222A1 true AU2022367222A1 (en) | 2024-05-02 |
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| EP (1) | EP4415816A1 (enExample) |
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| TW (1) | TW202322800A (enExample) |
| UY (1) | UY39979A (enExample) |
| WO (1) | WO2023064366A1 (enExample) |
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| CN119013030A (zh) * | 2022-01-25 | 2024-11-22 | 金耐特生物制药公司 | Cdk4/6激酶的抑制剂 |
| US20240199649A1 (en) * | 2022-11-03 | 2024-06-20 | Biosplice Therapeutics, Inc. | 4-aminopyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof |
| WO2024211797A1 (en) * | 2023-04-07 | 2024-10-10 | Biosplice Therapeutics, Inc. | Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof |
| CN119019402A (zh) * | 2023-05-24 | 2024-11-26 | 中国科学院上海有机化学研究所 | 作为lrrk2激酶抑制剂的多环化合物及其制备方法和用途 |
| WO2025024707A1 (en) * | 2023-07-26 | 2025-01-30 | Kinnate Biopharma Inc. | Inhibitors of cdk2/4/6 kinase |
| WO2025137469A1 (en) * | 2023-12-22 | 2025-06-26 | Biosplice Therapeutics, Inc. | 4-alkoxypyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4164559A (en) | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
| US4474752A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| US6440102B1 (en) | 1998-07-23 | 2002-08-27 | Durect Corporation | Fluid transfer and diagnostic system for treating the inner ear |
| DE19853299C2 (de) | 1998-11-19 | 2003-04-03 | Thomas Lenarz | Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs |
| US6120484A (en) | 1999-02-17 | 2000-09-19 | Silverstein; Herbert | Otological implant for delivery of medicament and method of using same |
| US6967023B1 (en) | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
| US6648873B2 (en) | 2001-09-21 | 2003-11-18 | Durect Corp. | Aural catheter system including anchor balloon and balloon inflation device |
| PT1730146E (pt) | 2004-03-30 | 2011-07-11 | Vertex Pharma | Azaindoles úteis como inibidores de jak e outras proteínas quinases |
| CA2594963A1 (en) | 2005-01-24 | 2006-07-27 | Neurosystec Corporation | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
| JP2011526931A (ja) | 2008-07-03 | 2011-10-20 | エグゼリクシス， インコーポレイテッド | Ｃｄｋモジュレーター |
| WO2011018894A1 (en) | 2009-08-10 | 2011-02-17 | Raqualia Pharma Inc. | Pyrrolopyrimidine derivatives as potassium channel modulators |
| US9260426B2 (en) | 2012-12-14 | 2016-02-16 | Arrien Pharmaceuticals Llc | Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors |
| EP2935248B1 (en) | 2012-12-21 | 2018-02-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2016010886A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| AU2016315881B2 (en) | 2015-09-03 | 2019-09-19 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of DYRK1A and uses thereof |
| FR3041640B1 (fr) | 2015-09-30 | 2019-05-17 | Les Laboratoires Servier | NOUVEAUX DERIVES DE PYRROLO[2,3-d]PYRIMIDINE, LEUR PROCEDE DE PREPRATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
| JP2020536920A (ja) * | 2017-10-10 | 2020-12-17 | サイロス ファーマシューティカルズ， インコーポレイテッド | ピロロトリアジン化合物およびｔａｍキナーゼを阻害する方法 |
| US20200039989A1 (en) | 2018-03-01 | 2020-02-06 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of dyrk/clk and uses thereof |
| EP3759072A4 (en) | 2018-03-01 | 2021-11-03 | The Trustees of Columbia University in the City of New York | COMPOUNDS, COMPOSITIONS AND METHODS FOR RELATING TOXIC STRESS FROM ENDOPLASMIC RETICULUM |
| WO2020006115A1 (en) | 2018-06-26 | 2020-01-02 | Betty Tam | Methods of treating cancer using a clk inhibitor |
| CN112867493A (zh) | 2018-10-16 | 2021-05-28 | 达纳-法伯癌症研究所有限公司 | 野生型和突变型lrrk2的氮杂吲哚抑制剂 |
| US20230000842A1 (en) | 2019-01-17 | 2023-01-05 | Samumed, Llc | Methods of treating cartilage disorders through inhibition of clk and dyrk |
| WO2021257863A1 (en) * | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| EP4182320A1 (en) | 2020-07-20 | 2023-05-24 | Nido Biosciences, Inc. | Indole compounds as androgen receptor modulators |
| US20230192686A1 (en) | 2021-10-12 | 2023-06-22 | Biosplice Therapeutics, Inc. | 1h-pyrrolo[2,3-b]pyridines and preparation and uses thereof |
| TW202330533A (zh) | 2021-10-12 | 2023-08-01 | 美商生物銜接醫療公司 | 7h-吡咯并[2,3-d]嘧啶及其製備及用途 |
| CN119604506A (zh) | 2022-06-23 | 2025-03-11 | 拜斯丽治疗有限公司 | 4-烷氧基吡咯并[2,1-f][1,2,4]三嗪以及其制备和用途 |
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2022
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| IL312157A (en) | 2024-06-01 |
| WO2023064366A1 (en) | 2023-04-20 |
| EP4415816A1 (en) | 2024-08-21 |
| CA3234831A1 (en) | 2023-04-20 |
| MX2024004552A (es) | 2024-06-04 |
| US12134625B2 (en) | 2024-11-05 |
| TW202322800A (zh) | 2023-06-16 |
| US20250171466A1 (en) | 2025-05-29 |
| JP2024539620A (ja) | 2024-10-29 |
| UY39979A (es) | 2023-04-14 |
| KR20240089275A (ko) | 2024-06-20 |
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