AU2022293672A1 - Hepcidin mimetics for treatment of hereditary hemochromatosis - Google Patents

Hepcidin mimetics for treatment of hereditary hemochromatosis Download PDF

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Publication number
AU2022293672A1
AU2022293672A1 AU2022293672A AU2022293672A AU2022293672A1 AU 2022293672 A1 AU2022293672 A1 AU 2022293672A1 AU 2022293672 A AU2022293672 A AU 2022293672A AU 2022293672 A AU2022293672 A AU 2022293672A AU 2022293672 A1 AU2022293672 A1 AU 2022293672A1
Authority
AU
Australia
Prior art keywords
seq
compound
peptide
isovaleric acid
palm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022293672A
Other languages
English (en)
Other versions
AU2022293672A9 (en
Inventor
Suneel Kumar Gupta
David Y. Liu
Nishit Bachulal Modi
Frank Horace VALONE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protagonist Therapeutics Inc
Original Assignee
Protagonist Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protagonist Therapeutics Inc filed Critical Protagonist Therapeutics Inc
Publication of AU2022293672A1 publication Critical patent/AU2022293672A1/en
Publication of AU2022293672A9 publication Critical patent/AU2022293672A9/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2022293672A 2021-06-14 2022-06-14 Hepcidin mimetics for treatment of hereditary hemochromatosis Pending AU2022293672A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163210453P 2021-06-14 2021-06-14
US63/210,453 2021-06-14
US202163252001P 2021-10-04 2021-10-04
US63/252,001 2021-10-04
US202263349841P 2022-06-07 2022-06-07
US63/349,841 2022-06-07
PCT/US2022/033378 WO2022266060A1 (en) 2021-06-14 2022-06-14 Hepcidin mimetics for treatment of hereditary hemochromatosis

Publications (2)

Publication Number Publication Date
AU2022293672A1 true AU2022293672A1 (en) 2023-12-14
AU2022293672A9 AU2022293672A9 (en) 2024-01-11

Family

ID=84527344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022293672A Pending AU2022293672A1 (en) 2021-06-14 2022-06-14 Hepcidin mimetics for treatment of hereditary hemochromatosis

Country Status (11)

Country Link
US (1) US20240293511A1 (https=)
EP (2) EP4355763A4 (https=)
JP (1) JP2024520861A (https=)
KR (1) KR20240021833A (https=)
AU (1) AU2022293672A1 (https=)
BR (1) BR112023026381A2 (https=)
CA (1) CA3220871A1 (https=)
IL (1) IL309166A (https=)
MX (1) MX2023015021A (https=)
TW (1) TW202317604A (https=)
WO (1) WO2022266060A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4091624A1 (en) 2013-03-15 2022-11-23 Protagonist Therapeutics, Inc. Hepcidin analogues and uses thereof
HRP20211448T1 (hr) 2014-05-16 2021-12-24 Protagonist Therapeutics, Inc. Alfa4beta7 integrin tioeter peptidni antagonisti
CN107206254B (zh) 2014-07-17 2021-08-24 领导医疗有限公司 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途
CA3089868A1 (en) 2018-02-08 2019-08-15 Protagonist Therapeutics, Inc. Conjugated hepcidin mimetics
AU2021209086A1 (en) 2020-01-15 2022-08-04 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
CA3167751A1 (en) 2020-01-15 2021-07-22 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
JP7397239B2 (ja) 2020-11-20 2023-12-12 ヤンセン ファーマシューティカ エヌ．ベー． インターロイキン－２３受容体のペプチド阻害剤の組成物
EP4370146A4 (en) 2021-07-14 2025-05-21 Janssen Biotech, Inc. Lipidated peptide inhibitors of the interleukin-23 receptor
WO2025207760A1 (en) * 2024-03-27 2025-10-02 Protagonist Therapeutics, Inc. Formulations of a hepcidin peptide analogue

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4091624A1 (en) * 2013-03-15 2022-11-23 Protagonist Therapeutics, Inc. Hepcidin analogues and uses thereof
WO2015200916A2 (en) * 2014-06-27 2015-12-30 Protagonist Therapeutics, Inc. Hepcidin and mini-hepcidin analogues and uses therof
EP3240799B1 (en) * 2014-12-29 2021-03-31 The Regents of the University of California S-alkylated hepcidin peptides and methods of making and using thereof
US20190002503A1 (en) * 2015-12-30 2019-01-03 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
PH12022550510A1 (en) * 2019-09-03 2023-09-04 Protagonist Therapeutics Inc Conjugated hepcidin mimetics

Also Published As

Publication number Publication date
IL309166A (en) 2024-02-01
JP2024520861A (ja) 2024-05-24
EP4737477A2 (en) 2026-05-06
US20240293511A1 (en) 2024-09-05
EP4355763A1 (en) 2024-04-24
KR20240021833A (ko) 2024-02-19
AU2022293672A9 (en) 2024-01-11
TW202317604A (zh) 2023-05-01
BR112023026381A2 (pt) 2024-03-05
WO2022266060A1 (en) 2022-12-22
CA3220871A1 (en) 2022-12-22
EP4355763A4 (en) 2025-07-30
MX2023015021A (es) 2024-01-26

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SREP Specification republished