AU2022286942A1 - Extended release drug delivery system for ocular drugs and methods of use - Google Patents

Extended release drug delivery system for ocular drugs and methods of use Download PDF

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Publication number
AU2022286942A1
AU2022286942A1 AU2022286942A AU2022286942A AU2022286942A1 AU 2022286942 A1 AU2022286942 A1 AU 2022286942A1 AU 2022286942 A AU2022286942 A AU 2022286942A AU 2022286942 A AU2022286942 A AU 2022286942A AU 2022286942 A1 AU2022286942 A1 AU 2022286942A1
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Australia
Prior art keywords
drug substance
methyl
ethyl
release
drug
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Pending
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AU2022286942A
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English (en)
Inventor
Andres Garcia
Xunpei LIU
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Eyedea Bio LLC
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Eyedea Bio LLC
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    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nanotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2022286942A 2021-06-01 2022-06-01 Extended release drug delivery system for ocular drugs and methods of use Pending AU2022286942A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163195697P 2021-06-01 2021-06-01
US63/195,697 2021-06-01
US202163281052P 2021-11-18 2021-11-18
US63/281,052 2021-11-18
PCT/US2022/031777 WO2022256412A2 (en) 2021-06-01 2022-06-01 Extended release drug delivery system for ocular drugs and methods of use

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AU2022286942A1 true AU2022286942A1 (en) 2023-12-14

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EP (1) EP4351612A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024520701A (cg-RX-API-DMAC7.html)
KR (1) KR20240039092A (cg-RX-API-DMAC7.html)
CN (1) CN121465998A (cg-RX-API-DMAC7.html)
AU (1) AU2022286942A1 (cg-RX-API-DMAC7.html)
BR (1) BR112023025185A2 (cg-RX-API-DMAC7.html)
CA (1) CA3221045A1 (cg-RX-API-DMAC7.html)
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Publication number Priority date Publication date Assignee Title
US2951014A (en) * 1957-01-03 1960-08-30 Upjohn Co Process for a stable oil suspension
PT1511516E (pt) * 2002-05-28 2009-02-20 Nycomed Gmbh Preparação farmacêutica para aplicação tópica
WO2004004682A2 (en) * 2002-07-02 2004-01-15 Laboratorios S.A.L.V.A.T., S.A. Stable oily suspension of microgranules
US9427423B2 (en) * 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
WO2007122624A2 (en) * 2006-04-24 2007-11-01 Technion Research And Development Foundation Ltd. Non-covalent complexes of bioactive agents with starch for oral delivery
RU2017105844A (ru) * 2014-08-08 2018-09-11 Форсайт Вижн4, Инк. Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения
WO2016057809A1 (en) * 2014-10-10 2016-04-14 Therakine Mg stearate - based composite nanoparticles, methods of preparation and applications

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