AU2022276538A1 - Artificial expression constructs for modulating gene expression in neurons within the thalamus - Google Patents

Artificial expression constructs for modulating gene expression in neurons within the thalamus Download PDF

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Publication number
AU2022276538A1
AU2022276538A1 AU2022276538A AU2022276538A AU2022276538A1 AU 2022276538 A1 AU2022276538 A1 AU 2022276538A1 AU 2022276538 A AU2022276538 A AU 2022276538A AU 2022276538 A AU2022276538 A AU 2022276538A AU 2022276538 A1 AU2022276538 A1 AU 2022276538A1
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ehgt
seq
coding sequence
heterologous coding
sequence
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AU2022276538A9 (en
Inventor
Tanya DAIGLE
Edward Sebastian LEIN
Boaz P. LEVI
John K. Mich
Amanda MITCHELL
Bosiljka Tasic
Jonathan Ting
Natalie WEED
Hongkui Zeng
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Allen Institute
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Allen Institute
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Health & Medical Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2022276538A 2021-05-21 2022-05-20 Artificial expression constructs for modulating gene expression in neurons within the thalamus Pending AU2022276538A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163191832P 2021-05-21 2021-05-21
US63/191,832 2021-05-21
PCT/US2022/030371 WO2022246276A2 (en) 2021-05-21 2022-05-20 Artificial expression constructs for modulating gene expression in neurons within the thalamus

Publications (2)

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AU2022276538A1 true AU2022276538A1 (en) 2023-11-09
AU2022276538A9 AU2022276538A9 (en) 2023-11-16

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AU2022276538A Pending AU2022276538A1 (en) 2021-05-21 2022-05-20 Artificial expression constructs for modulating gene expression in neurons within the thalamus

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US (1) US20240254514A1 (https=)
EP (1) EP4341410A4 (https=)
JP (1) JP2024519955A (https=)
AU (1) AU2022276538A1 (https=)
CA (1) CA3219142A1 (https=)
WO (1) WO2022246276A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023060112A1 (en) * 2021-10-05 2023-04-13 Allen Institute Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type

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* Cited by examiner, † Cited by third party
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CA3052290A1 (en) * 2017-02-10 2018-08-16 The Rockefeller University Methods for cell-type specific profiling to identify drug targets
US20210395780A1 (en) * 2018-11-05 2021-12-23 Allen Institute Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons
EP3923995A4 (en) * 2019-02-15 2023-05-17 Allen Institute ARTIFICIAL EXPRESSION RECOMBINANTS FOR THE SELECTIVE MODULATION OF GENE EXPRESSION IN SELECTED NEURON CELL POPULATIONS
JP2026509974A (ja) * 2023-02-02 2026-03-26 アレン インスティテュート 脊髄内の細胞の遺伝子発現を調節するための人工発現コンストラクト

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CA3219142A1 (en) 2022-11-24
WO2022246276A3 (en) 2022-12-29
JP2024519955A (ja) 2024-05-21
US20240254514A1 (en) 2024-08-01
EP4341410A4 (en) 2026-02-11
WO2022246276A2 (en) 2022-11-24
AU2022276538A9 (en) 2023-11-16
EP4341410A2 (en) 2024-03-27

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