AU2022253450A1 - Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer - Google Patents

Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer Download PDF

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Publication number
AU2022253450A1
AU2022253450A1 AU2022253450A AU2022253450A AU2022253450A1 AU 2022253450 A1 AU2022253450 A1 AU 2022253450A1 AU 2022253450 A AU2022253450 A AU 2022253450A AU 2022253450 A AU2022253450 A AU 2022253450A AU 2022253450 A1 AU2022253450 A1 AU 2022253450A1
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Prior art keywords
methyl
oxoisoindolin
piperidine
dione
pyridin
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AU2022253450A
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English (en)
Inventor
James Aaron Balog
Yan Chen
Emily Charlotte CHERNEY
Godwin Kwame KUMI
Guo Li
Ashok Vinayak Purandare
Weifang Shan
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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AU2022253450A 2021-04-05 2022-04-04 Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer Pending AU2022253450A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163170865P 2021-04-05 2021-04-05
US63/170,865 2021-04-05
US202163189318P 2021-05-17 2021-05-17
US63/189,318 2021-05-17
PCT/US2022/023236 WO2022216573A1 (en) 2021-04-05 2022-04-04 Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer

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US (1) US20250346574A1 (https=)
EP (1) EP4320125A1 (https=)
JP (1) JP2024515545A (https=)
KR (1) KR20230167067A (https=)
AU (1) AU2022253450A1 (https=)
BR (1) BR112023020410A2 (https=)
CA (1) CA3214240A1 (https=)
IL (1) IL307338A (https=)
MX (1) MX2023011408A (https=)
WO (1) WO2022216573A1 (https=)

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JP2022533260A (ja) * 2019-05-24 2022-07-21 バイオセリックス， インコーポレイテッド タンパク質を標的とする化合物及びその医薬組成物並びにそれらの治療的応用
JP7629459B2 (ja) * 2019-11-19 2025-02-13 ブリストル－マイヤーズ スクイブ カンパニー Ｈｅｌｉｏｓタンパク質の阻害剤として有用な化合物
JP7819176B2 (ja) * 2020-08-03 2026-02-24 ノバルティス アーゲー ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用

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