AU2021295456A1 - Inhibitors of acid sphingomyelinase for preventing and treating the covid-19 disease - Google Patents

Inhibitors of acid sphingomyelinase for preventing and treating the covid-19 disease Download PDF

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Publication number
AU2021295456A1
AU2021295456A1 AU2021295456A AU2021295456A AU2021295456A1 AU 2021295456 A1 AU2021295456 A1 AU 2021295456A1 AU 2021295456 A AU2021295456 A AU 2021295456A AU 2021295456 A AU2021295456 A AU 2021295456A AU 2021295456 A1 AU2021295456 A1 AU 2021295456A1
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Prior art keywords
fiasma
agent
covid
patients
use according
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AU2021295456A
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English (en)
Inventor
Miriam ABELLÁN
Alexander CARPINTEIRO
Pedro DE LA MUELA
Erich Gulbins
Nicolas HOERTEL
Johannes Kornhuber
Frédéric LIMOSIN
Marina Lucia SANCHEZ RICO
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Assistance Publique Hopitaux de Paris APHP
Universite Paris Cite
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Assistance Publique Hopitaux de Paris APHP
Universite Paris Cite
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Priority claimed from EP20305698.1A external-priority patent/EP3928775A1/en
Priority claimed from EP20306117.1A external-priority patent/EP3973961A1/en
Priority claimed from US17/146,013 external-priority patent/US20220347127A1/en
Application filed by Assistance Publique Hopitaux de Paris APHP, Universite Paris Cite filed Critical Assistance Publique Hopitaux de Paris APHP
Publication of AU2021295456A1 publication Critical patent/AU2021295456A1/en
Pending legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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AU2021295456A 2020-06-24 2021-06-24 Inhibitors of acid sphingomyelinase for preventing and treating the covid-19 disease Pending AU2021295456A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP20305698.1 2020-06-24
EP20305698.1A EP3928775A1 (en) 2020-06-24 2020-06-24 Use of antidepressant agents for treating the covid-19 disease
EP20306117.1A EP3973961A1 (en) 2020-09-29 2020-09-29 Use of hydroxyzine and antihistamine analogs for treating the covid-19 disease
EP20306117.1 2020-09-29
US17/146,013 2021-01-11
US17/146,013 US20220347127A1 (en) 2021-01-11 2021-01-11 Use of antidepressant agents for preventing and treating the covid-19 disease
EP21305188.1 2021-02-12
EP21305188 2021-02-12
PCT/EP2021/067427 WO2021260152A1 (en) 2020-06-24 2021-06-24 Inhibitors of acid sphingomyelinase for preventing and treating the covid-19 disease

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