AU2021266232A1 - Nitrile-containing antiviral compounds - Google Patents

Nitrile-containing antiviral compounds

Info

Publication number
AU2021266232A1
AU2021266232A1 AU2021266232A AU2021266232A AU2021266232A1 AU 2021266232 A1 AU2021266232 A1 AU 2021266232A1 AU 2021266232 A AU2021266232 A AU 2021266232A AU 2021266232 A AU2021266232 A AU 2021266232A AU 2021266232 A1 AU2021266232 A1 AU 2021266232A1
Authority
AU
Australia
Prior art keywords
nitrile
antiviral compounds
containing antiviral
compounds
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2021266232A
Other versions
AU2021266232B1 (en
AU2021266232C1 (en
Inventor
Dafydd Rhys Owen
Martin Youngjin Pettersson
Matthew Richard Reese
Matthew Forrest Sammons
Jamison Bryce Tuttle
Patrick Robert Verhoest
Liuqing WEI
Qingyi YANG
Xiaojing Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority claimed from PCT/IB2021/057281 external-priority patent/WO2021250648A1/en
Publication of AU2021266232A1 publication Critical patent/AU2021266232A1/en
Publication of AU2021266232B1 publication Critical patent/AU2021266232B1/en
Priority to AU2022202158A priority Critical patent/AU2022202158B2/en
Application granted granted Critical
Publication of AU2021266232C1 publication Critical patent/AU2021266232C1/en
Priority to AU2022221493A priority patent/AU2022221493B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

AU2021266232A 2020-09-03 2021-08-06 Nitrile-containing antiviral compounds Active AU2021266232C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022202158A AU2022202158B2 (en) 2020-09-03 2022-03-30 Nitrile-containing antiviral compounds
AU2022221493A AU2022221493B2 (en) 2020-09-03 2022-08-25 Nitrile-containing antiviral compounds

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063073982P 2020-09-03 2020-09-03
US63/073,982 2020-09-03
US202163143435P 2021-01-29 2021-01-29
US63/143,435 2021-01-29
US202163170158P 2021-04-02 2021-04-02
US63/170,158 2021-04-02
US202163194241P 2021-05-28 2021-05-28
US63/194,241 2021-05-28
PCT/IB2021/057281 WO2021250648A1 (en) 2020-09-03 2021-08-06 Nitrile-containing antiviral compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022202158A Division AU2022202158B2 (en) 2020-09-03 2022-03-30 Nitrile-containing antiviral compounds

Publications (3)

Publication Number Publication Date
AU2021266232A1 true AU2021266232A1 (en) 2021-12-16
AU2021266232B1 AU2021266232B1 (en) 2022-02-03
AU2021266232C1 AU2021266232C1 (en) 2022-06-23

Family

ID=77411985

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2021266232A Active AU2021266232C1 (en) 2020-09-03 2021-08-06 Nitrile-containing antiviral compounds
AU2022202158A Active AU2022202158B2 (en) 2020-09-03 2022-03-30 Nitrile-containing antiviral compounds
AU2022221493A Active AU2022221493B2 (en) 2020-09-03 2022-08-25 Nitrile-containing antiviral compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2022202158A Active AU2022202158B2 (en) 2020-09-03 2022-03-30 Nitrile-containing antiviral compounds
AU2022221493A Active AU2022221493B2 (en) 2020-09-03 2022-08-25 Nitrile-containing antiviral compounds

Country Status (33)

Country Link
US (4) US11351149B2 (en)
EP (2) EP3953330B1 (en)
JP (2) JP7126628B2 (en)
KR (2) KR20220045251A (en)
CN (2) CN116789648A (en)
AU (3) AU2021266232C1 (en)
BR (2) BR122023004755B1 (en)
CA (1) CA3137824C (en)
CL (1) CL2021002965A1 (en)
CO (1) CO2021015067A2 (en)
CR (1) CR20210558A (en)
DK (1) DK3953330T3 (en)
DO (1) DOP2023000168A (en)
EC (1) ECSP21080528A (en)
ES (1) ES2932173T3 (en)
GE (2) GEP20247607B (en)
HR (1) HRP20221379T1 (en)
HU (1) HUE060811T2 (en)
IL (2) IL299071A (en)
LT (1) LT3953330T (en)
MD (1) MD3953330T2 (en)
MX (1) MX2021013679A (en)
MY (1) MY196455A (en)
NZ (1) NZ782196A (en)
PE (1) PE20220432A1 (en)
PL (1) PL3953330T3 (en)
PT (1) PT3953330T (en)
RS (1) RS63714B1 (en)
SI (1) SI3953330T1 (en)
TW (2) TW202317540A (en)
UY (1) UY39372A (en)
WO (1) WO2021250648A1 (en)
ZA (3) ZA202108834B (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11124497B1 (en) 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
JP2023530267A (en) 2020-06-10 2023-07-14 アリゴス セラピューティクス インコーポレイテッド Antiviral compounds for treating coronavirus, picornavirus and norovirus infections
CN116348477A (en) 2020-07-20 2023-06-27 英安塔制药有限公司 Functionalized peptides as antiviral agents
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11976084B2 (en) 2020-11-23 2024-05-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
EP4255401A1 (en) * 2020-12-01 2023-10-11 Purdue Research Foundation Compounds for the treatment of sars
US20220204476A1 (en) * 2020-12-21 2022-06-30 The Governors Of The University Of Alberta Rna virus inhibitor compounds and uses thereof
CN117820248A (en) 2021-04-14 2024-04-05 盐野义制药株式会社 Triazine derivative with virus proliferation inhibition effect and pharmaceutical composition containing triazine derivative
JP7469562B2 (en) 2021-04-16 2024-04-16 福建▲広▼生中霖生物科技有限公司 Ring-modified proline short peptide compounds and uses thereof
WO2022235605A1 (en) 2021-05-04 2022-11-10 Enanta Pharmaceuticals, Inc. Novel macrocyclic antiviral agents
US11857617B2 (en) 2021-05-10 2024-01-02 Topelia Aust Limited (652 771 670) Methods for treating, ameliorating or preventing infections using drug and vaccination combination treatment
US11319325B1 (en) 2021-05-11 2022-05-03 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
TW202313567A (en) * 2021-06-02 2023-04-01 開曼群島商艾森醫藥有限公司 Protease inhibitors as antivirals
US20230033285A1 (en) * 2021-06-16 2023-02-02 The Scripps Research Institute Protease Inhibitors for Treatment of Coronavirus Infections
CN113444144A (en) * 2021-06-23 2021-09-28 周龙兴 Protease inhibitor and pharmaceutical composition and application thereof
KR20240035513A (en) 2021-07-09 2024-03-15 알리고스 테라퓨틱스 인코포레이티드 antiviral compounds
US11339170B1 (en) 2021-07-23 2022-05-24 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
CN114149415A (en) * 2021-07-26 2022-03-08 中国药科大学 Peptide-like compound and derivative, preparation method, pharmaceutical composition and application thereof
US11325916B1 (en) 2021-07-29 2022-05-10 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023023631A1 (en) * 2021-08-18 2023-02-23 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
WO2023054292A1 (en) 2021-09-28 2023-04-06 塩野義製薬株式会社 Pharmaceutical composition containing triazine derivative
CN114957381A (en) * 2021-10-22 2022-08-30 广州谷森制药有限公司 Novel deuterated cyano compound, preparation method, composition and application thereof
US11858945B2 (en) 2021-11-12 2024-01-02 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
US11919910B2 (en) 2021-11-12 2024-03-05 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023086352A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
WO2023088418A1 (en) * 2021-11-20 2023-05-25 Fochon Biosciences, Ltd. Compounds as sars-cov-2 inhibitors
AU2022333823A1 (en) 2021-11-24 2024-05-02 Shionogi & Co., Ltd. Preparation for oral administration containing triazine derivative
WO2023095860A1 (en) * 2021-11-26 2023-06-01 塩野義製薬株式会社 Covid-19 treatment medicine characterized by combining 3cl protease inhibitor and covid-19 treatment drug
WO2023093834A1 (en) * 2021-11-26 2023-06-01 先声再明医药有限公司 Pyrrolidine antiviral compound
CN115490626A (en) * 2021-11-26 2022-12-20 杭州科巢生物科技有限公司 PF-07321332 key chiral compound and preparation method thereof
CN115010639B (en) * 2021-12-14 2024-03-08 上海艾洋化学科技有限公司 Intermediate compound and preparation method and application thereof
WO2023116734A1 (en) * 2021-12-21 2023-06-29 Shanghai Micurx Pharmaceutical Co., Ltd. Fused pyrrolidine compounds and compositions for treatment of respiratory viral infections
CN116888099A (en) * 2021-12-22 2023-10-13 福建广生中霖生物科技有限公司 Short peptide compound containing beta-amino ketone and application thereof
CN114456101A (en) * 2021-12-23 2022-05-10 上海璨谊生物科技有限公司 Synthesis method of key intermediate for synthesizing PF-07321332
WO2023125535A1 (en) * 2021-12-28 2023-07-06 石药集团中奇制药技术(石家庄)有限公司 Deuterated peptidomimetic compound and use thereof
CN114409727A (en) * 2021-12-28 2022-04-29 苏州康纯医药科技有限公司 Preparation method of anti-coronavirus 3CLPRO inhibitor
WO2023125825A1 (en) * 2021-12-29 2023-07-06 Shanghai Curegene Pharmaceutical Co., Ltd. Anticoronviral compounds and compositions and uses thereof
CN114213275B (en) * 2021-12-31 2023-08-04 戊言医药科技(上海)有限公司 Intermediate product for synthesizing Pa Luo Weide and preparation method
TW202334123A (en) * 2021-12-31 2023-09-01 大陸商蘇州愛科百發生物醫藥技術有限公司 Compounds, conjugates and methods thereof for preventing and treating coronavirus infection
WO2023133174A1 (en) * 2022-01-07 2023-07-13 Merck Sharp & Dohme Llc Protease inhibitors for treating or preventing coronavirus infection
CN114426568B (en) * 2022-01-11 2023-04-25 嘉兴安谛康生物科技有限公司 2-oxo-3-pyrrolidinyl propionitrile compounds, pharmaceutical composition and application thereof
WO2023134730A1 (en) * 2022-01-13 2023-07-20 先声再明医药有限公司 Amide antiviral compound
US11760722B2 (en) * 2022-01-18 2023-09-19 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
WO2023139402A1 (en) * 2022-01-18 2023-07-27 Ascletis Bioscience Co., Ltd. Inhibitors of cysteine proteases and methods of use thereof
CN114057627B (en) * 2022-01-18 2022-04-01 南京桦冠生物技术有限公司 Preparation method of hepatitis C and neocorolla drug intermediate and salt thereof
CN114948950A (en) * 2022-01-19 2022-08-30 广州谷森制药有限公司 Pharmaceutical composition and antiviral application thereof
CN114394927B (en) * 2022-01-20 2023-03-31 汉瑞药业(荆门)有限公司 Process for the preparation of 6, 6-dimethyl-3-azabicyclo [3.1.0] hexane-2-carboxylic acid
CN114437043B (en) * 2022-02-02 2023-06-16 浙江乐普药业股份有限公司 Preparation method of anti-new crown drug Nirmatrelvir
WO2023148747A1 (en) * 2022-02-07 2023-08-10 Dr. Reddy’S Institute Of Life Sciences Improved processes for preparation of nirmatrelvir and intermediates thereof
WO2023151188A1 (en) * 2022-02-08 2023-08-17 上海皓元医药股份有限公司 Green synthesis method of antiviral drug intermediate
CN114230504B (en) * 2022-02-24 2022-06-03 南京桦冠生物技术有限公司 Synthetic method of pyrrolidone intermediate
CN114668737A (en) * 2022-03-02 2022-06-28 乐普制药科技有限公司 Compound bilayer tablet containing ritonavir pellets for treating novel coronavirus
CN114573470B (en) * 2022-03-17 2023-12-15 浙江海洲制药有限公司 Method for synthesizing N-trifluoroacetyl tertiary leucine
CN114957382A (en) * 2022-03-17 2022-08-30 广州谷森制药有限公司 Deuterated nimarevir crystal form I and preparation method thereof
CN114605436B (en) * 2022-03-23 2023-07-21 浙江九洲药业股份有限公司 Intermediate of Pa Luo Weide or boceprevir, preparation method and application
WO2023180189A1 (en) * 2022-03-23 2023-09-28 Exscientia Ai Limited Mpro targeting antiviral compounds
CN114437044B (en) * 2022-03-24 2022-10-04 山东诚创蓝海医药科技有限公司 Preparation method of nemadevir
CN114702425B (en) * 2022-03-28 2024-04-19 苏州汉酶生物技术有限公司 Process for the preparation of (S) -2-amino- (S) -3- [ pyrrolidone-2' ] alanine derivatives and intermediates
US11648300B1 (en) * 2022-03-31 2023-05-16 Asavi Llc Pharmaceutical combination therapy and prevention with aprotinin + nirmatrelvir of SARS-CoV-2 and/or disease associated with this infection, including COVID-19
CN114957383A (en) * 2022-04-01 2022-08-30 中国科学院上海药物研究所 Peptide-like compound, preparation method thereof, pharmaceutical composition and application
WO2023195530A1 (en) * 2022-04-08 2023-10-12 塩野義製薬株式会社 Uracil derivative having viral growth inhibitory activity and pharmaceutical composition containing same
CN114957087A (en) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 Preparation method of intermediate of palovaried
WO2023200364A1 (en) * 2022-04-15 2023-10-19 Общество С Ограниченной Ответственностью "Промомед Рус" Methods for producing (1r,2s,5s)-n-[(1s)-1-cyano-2-[(3s)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2s)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
CN114702545A (en) * 2022-04-19 2022-07-05 海化生命(厦门)科技有限公司 Preparation method of anti-neocoronavirus medicine nimacrivir
CN117126229A (en) * 2022-05-19 2023-11-28 浙江海正药业股份有限公司 HS378 crystal form and preparation method thereof
CN114957053B (en) * 2022-05-20 2023-12-22 中国医学科学院医药生物技术研究所 Oxoethylene compound or pharmaceutically acceptable salt thereof, preparation method and application thereof, pharmaceutical composition and application thereof
CN114989045B (en) * 2022-06-14 2023-09-08 斯坦德药典标准物质研发(湖北)有限公司 Intermediate for synthesizing Namactetvir and preparation method thereof and method for synthesizing Namactetvir
WO2023245162A2 (en) * 2022-06-17 2023-12-21 Trawsfynydd Therapeutics, Inc. Compounds for treatment a coronavirus infection
WO2024003737A1 (en) 2022-06-30 2024-01-04 Pfizer Inc. Process and intermediates useful for preparing nirmatrelvir
CN116970028A (en) * 2022-07-08 2023-10-31 腾讯科技(深圳)有限公司 Macrocyclic peptoid protease inhibitors and uses thereof
CN116621918B (en) * 2022-07-20 2023-10-31 深圳信立泰药业股份有限公司 Spiro compound and preparation method and application thereof
CN117503776A (en) * 2022-08-05 2024-02-06 临港国家实验室 Pharmaceutical composition and application thereof
WO2024078618A1 (en) * 2022-10-14 2024-04-18 福建广生中霖生物科技有限公司 Crystal form of cyano-substituted polypeptide compound and preparation method therefor
WO2024089159A1 (en) 2022-10-27 2024-05-02 Ubiq Holding B.V. Main protease inhibitors
CN116283741B (en) * 2023-05-10 2023-09-05 江苏欣诺科催化剂股份有限公司 Bisimine ligand, preparation method and application thereof
CN116763898A (en) * 2023-08-21 2023-09-19 北京科翔中升医药科技有限公司 Application of protease inhibitor compound in preparation of cat coronavirus infection medicines

Family Cites Families (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583238A (en) 1990-11-19 1996-12-10 G. D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
DK0727419T3 (en) 1992-12-29 2002-06-10 Abbott Lab Intermediates for the preparation of compounds that inhibit retroviral protease
US5543417A (en) 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
CN1212706A (en) 1996-02-13 1999-03-31 阿克佐诺贝尔公司 Serine protease inhibitors
IL120310A (en) 1996-03-01 2002-02-10 Akzo Nobel Nv Serine protease inhibitors and pharmaceutical compositions containing them
AU2429197A (en) 1996-04-04 1997-10-29 Bristol-Myers Squibb Company Cephalosporin derivatives
DE19748470A1 (en) 1997-11-03 1999-05-06 Hoechst Schering Agrevo Gmbh Carbamoylphenylsulfonylureas, process for their preparation and their use as herbicides and plant growth regulators
US20050267148A1 (en) 1998-07-15 2005-12-01 Teijin Limited Benzimidazole derivative
TR200100047T2 (en) 1998-07-15 2001-10-22 Teijin Limited Thiobenzimidazole derivatives
CN1372566A (en) 1999-08-04 2002-10-02 阿格罗尼制药公司 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
PA8507801A1 (en) 1999-12-03 2002-08-26 Agouron Pharma ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES AND THE MATERIALS FOR SYNTHESIS
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
US7012066B2 (en) 2000-07-21 2006-03-14 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
TW200301079A (en) 2001-12-21 2003-07-01 Syngenta Participations Ag Avermectin B1 derivatives having an aminosulfonyloxy substituent in the 4"-position
PE20030857A1 (en) 2002-01-23 2003-10-25 Schering Corp COMPOUNDS AS INHIBITORS OF THE PROTEASE SERINE NS3 OF THE HEPATITIS C VIRUS
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
DE60322857D1 (en) 2002-03-25 2008-09-25 Nippon Kayaku Kk NEW ALPHA-AMINO-N- (DIAMINOPHOSPHINYL) LACTAM DERIVATIVE
AR040126A1 (en) 2002-05-29 2005-03-16 Glaxo Group Ltd PHENYL SULFONYL COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT
AR040149A1 (en) 2002-06-07 2005-03-16 Novartis Ag AMINO ACETONITRILE COMPOUNDS, A PROCESS FOR THE PREPARATION, COMPOSITION, AND USE OF THE COMPOUND
UA84404C2 (en) 2002-06-12 2008-10-27 Байоджен Айдек Ма Инк. Method of treating ischemia reperfusion injury using adenosine receptor antagonists
GB0220187D0 (en) 2002-08-30 2002-10-09 Novartis Ag Organic compounds
EP1572660B1 (en) 2002-12-20 2011-01-26 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
WO2004093860A1 (en) 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
US20040235952A1 (en) 2003-05-05 2004-11-25 Agouron Pharmaceuticals, Inc. Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase
SE0301320D0 (en) 2003-05-06 2003-05-06 Astrazeneca Ab Positive modulators of nicotinic acetylcholine receptors
JP2007527389A (en) 2003-06-30 2007-09-27 メルク エンド カムパニー インコーポレーテッド Radioactive cannabinoid-1 receptor modulator
CA2536570A1 (en) 2003-08-26 2005-03-10 Schering Corporation Novel peptidomimetic ns3-serine protease inhibitors of hepatitis c virus
US20060014821A1 (en) 2003-08-27 2006-01-19 Agouron Pharmaceuticals, Inc. Inhibitors of SARS 3C like protease
WO2005023294A2 (en) 2003-09-05 2005-03-17 The General Hospital Corporation Polyacetal drug conjugates as release system
AU2004298498B2 (en) 2003-12-11 2008-09-11 Schering Corporation Inhibitors of hepatitis C virus NS3/NS4a serine protease
AU2004312547A1 (en) 2003-12-31 2005-07-21 Taigen Biotechnology Protease inhibitors
US7462594B2 (en) 2003-12-31 2008-12-09 Taigen Biotechnology Co., Ltd. Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases
CA2554771A1 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
RU2006134002A (en) 2004-02-27 2008-04-10 Шеринг Корпорейшн (US) NEW COMPOUNDS OPERATING AS NS3 SERIN PROTEASE INHIBITORS HEPATITIS C VIRUS
WO2005085242A1 (en) 2004-02-27 2005-09-15 Schering Corporation Novel ketoamides with cyclic p4's as inhibitors of ns3 serine protease of hepatitis c virus
TW200536528A (en) 2004-02-27 2005-11-16 Schering Corp Novel inhibitors of hepatitis C virus NS3 protease
TWI314927B (en) 2004-02-27 2009-09-21 Schering Corporatio Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease
US7816326B2 (en) 2004-02-27 2010-10-19 Schering Corporation Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
WO2005113580A1 (en) 2004-05-21 2005-12-01 Pfizer Inc. Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
US20050288338A1 (en) 2004-06-24 2005-12-29 Wenqing Yao Amido compounds and their use as pharmaceuticals
US8680290B2 (en) 2004-09-03 2014-03-25 Syngenta Limited Isoxazoline derivatives and their use as herbicides
US7531548B2 (en) 2004-09-30 2009-05-12 Tibotec Pharmaceuticals Ltd HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines
AU2005288864B2 (en) 2004-09-30 2012-08-23 Janssen Sciences Ireland Uc HIV inhibiting 5-heterocyclyl pyrimidines
CN100363346C (en) * 2004-10-22 2008-01-23 清华大学 Small molecular inhibiting agent for coronavirus main proteinase, its preparation method and uses
CA2577588C (en) 2004-10-29 2013-09-10 Tibotec Pharmaceuticals Ltd. Hiv inhibiting bicyclic pyrimidine derivatives
WO2006061714A2 (en) 2004-12-09 2006-06-15 Pfizer Inc. Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
GB2422829A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
GB2422831A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
DE602006002887D1 (en) 2005-04-14 2008-11-06 Hoffmann La Roche TRICYCLIC AZOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL AGENTS
WO2006108489A1 (en) 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
US20060281689A1 (en) 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
US20060276406A1 (en) 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis C virus
MX2007016064A (en) 2005-06-16 2008-03-10 Novartis Ag Compositions and methods for viral inhibition.
US20090170846A1 (en) 2005-10-03 2009-07-02 Pfizer Inc Inhibitors of the hiv integrase enzyme
WO2007058832A2 (en) 2005-11-12 2007-05-24 Boehringer Ingelheim International Gmbh Pyrrolo (2, 3-b) pyridine derivatives useful as tec kinase inhibitors
DE102005055354A1 (en) 2005-11-21 2007-10-31 Merck Patent Gmbh Substituted 5-phenyl-3,6-dihydro-2-oxo-6H- [1,3,4] thiadiazines
BRPI0619955A2 (en) 2005-12-15 2011-10-25 Hoffmann La Roche tricyclic lactam derivatives, their production and their uses as pharmaceutical agents
DE102006012251A1 (en) 2006-03-15 2007-11-08 Grünenthal GmbH Substituted 4-aminoquinazoline derivatives and their use for the preparation of medicaments
US20080004306A1 (en) 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
TW200815351A (en) 2006-05-02 2008-04-01 Astrazeneca Ab Novel compounds
WO2008037266A1 (en) 2006-09-25 2008-04-03 Universite Libre De Bruxelles Inhibitors of conventional protein kinase c isozymes and use thereof for treating inflammatory diseases
US20100093738A1 (en) 2006-10-06 2010-04-15 Basf Se Fungicidal Compounds and Fungicidal Compositions
US20090137549A1 (en) 2006-11-09 2009-05-28 Paul John Edward Novel compounds useful for the treatment of degenerative & inflamatory diseases
MY155009A (en) 2006-12-27 2015-08-28 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
JP5405316B2 (en) 2006-12-27 2014-02-05 サノフイ Cycloalkylamine substituted isoquinoline derivatives
JP5491871B2 (en) 2007-02-28 2014-05-14 アドビナス セラピュティックス プライベート リミテッド 2,2,2-Trisubstituted acetamide derivatives as glucokinase activators, methods and pharmaceutical applications thereof
JP2008280339A (en) 2007-04-12 2008-11-20 Sumitomo Chemical Co Ltd Hydrazide compound and agent comprising the same for controlling harmful arthropod
JP2008260716A (en) 2007-04-12 2008-10-30 Sumitomo Chemical Co Ltd Hydrazide compound and harmful arthropod-controlling agent containing the same
AU2008256859A1 (en) 2007-05-24 2008-12-04 Memory Pharmaceuticals Corporation 4' substituted compounds having 5-HT6 receptor affinity
CN101902912A (en) 2007-11-06 2010-12-01 纳幕尔杜邦公司 Fungicidal amines
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
GB0808953D0 (en) 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808967D0 (en) 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808951D0 (en) 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808947D0 (en) 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808952D0 (en) 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808950D0 (en) 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
AU2009251291B2 (en) 2008-05-30 2013-05-02 F. Hoffmann-La Roche Ag Purine PI3K inhibitor compounds and methods of use
WO2010014179A1 (en) 2008-07-31 2010-02-04 Duke University Photolabile caged transition metal complexes and methods of using the same
US20110312945A1 (en) 2008-10-01 2011-12-22 James Jia Crth2 modulators
WO2010042646A1 (en) 2008-10-10 2010-04-15 Amgen Inc. Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof
WO2010042649A2 (en) 2008-10-10 2010-04-15 Amgen Inc. PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF
WO2010075257A1 (en) 2008-12-22 2010-07-01 Chemocentryx, Inc. C5ar antagonists
WO2010111060A1 (en) 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
WO2010138706A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating breast cancer
US8697662B2 (en) 2009-05-27 2014-04-15 Ptc Therapeutics, Inc. Methods for treating Kaposi sarcoma
US8703726B2 (en) 2009-05-27 2014-04-22 Ptc Therapeutics, Inc. Methods for treating prostate conditions
US20120157402A1 (en) 2009-05-27 2012-06-21 Liangxian Cao Methods for treating brain tumors
WO2010138695A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating neurofibromatosis
WO2010144686A1 (en) 2009-06-10 2010-12-16 North Carolina State University Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives
WO2011003932A2 (en) 2009-07-10 2011-01-13 Basf Se Method for the direct amination of hydrocarbons into amino hydrocarbons, including electrochemical separation of hydrogen
SG177709A1 (en) 2009-07-21 2012-02-28 Gilead Sciences Inc Inhibitors of flaviviridae viruses
CN102596959A (en) 2009-07-31 2012-07-18 拜奥克里斯特制药公司 Pyrrolo [1, 2-b] pyridazine derivatives as JANUS kinase inhibitors
JP2011057661A (en) 2009-08-14 2011-03-24 Bayer Cropscience Ag Pesticidal carboxamides
TW201124078A (en) 2009-12-22 2011-07-16 Du Pont Fungicidal 2-(bicyclic aryloxy) carboxamides
PT2523951E (en) 2010-01-15 2015-09-14 Gilead Sciences Inc Inhibitors of flaviviridae viruses
EP3219713A1 (en) 2010-01-15 2017-09-20 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
EP2539334A1 (en) 2010-02-25 2013-01-02 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Process for the preparation of -acyloxy -formamido amides
WO2011132048A1 (en) 2010-04-19 2011-10-27 Glenmark Pharmaceutical S.A. Heteroaryl compounds as pde10a inhibitors
WO2011133659A2 (en) 2010-04-20 2011-10-27 Emory University Inhibitors of hif and angiogenesis
US9198891B2 (en) 2010-05-21 2015-12-01 New York University Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase
WO2012022045A1 (en) 2010-08-20 2012-02-23 Hutchison Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
BR112013005223A2 (en) 2010-09-03 2016-05-03 Bayer Ip Gmbh "Substituted fused pyrimidinones and dihydropyrimidinones."
WO2012058531A2 (en) 2010-10-29 2012-05-03 North Carolina State University Modulation of response regulators by imidazole derivatives
WO2012058173A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
WO2012087372A1 (en) 2010-12-22 2012-06-28 E. I. Du Pont De Nemours And Company Fungicidal 2-(bicyclic aryloxy)carboxamides
WO2012125668A1 (en) 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
RU2013153588A (en) 2011-05-04 2015-06-10 Мерк Шарп И Доум Корп. MEDICINES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PRODUCING THEM
KR20140041519A (en) 2011-06-07 2014-04-04 다이닛본 스미토모 세이야꾸 가부시끼가이샤 Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
CN102827073A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
CN102838523A (en) 2011-06-23 2012-12-26 南开大学 Anti-enterovirus 71 (EV71) valerolactam compounds, preparation method and uses thereof
JP6121658B2 (en) 2011-06-29 2017-04-26 大塚製薬株式会社 Therapeutic compounds and related methods of use
US8716297B2 (en) 2011-07-15 2014-05-06 Abbvie Inc. Chemical entities to be used for Wee1 inhibition for the treatment of cancer
EP2748137A1 (en) 2011-08-22 2014-07-02 Syngenta Participations AG Dihydrofuran derivatives as insecticidal compounds
US9474759B2 (en) 2011-09-27 2016-10-25 Kansas State University Research Foundation Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
CN103130710B (en) 2011-11-29 2015-12-16 南开大学 Anti-enteric virus71 (EV71) hexanolactam aldehyde compound and its production and use
CN103145608B (en) 2011-12-07 2015-09-02 南开大学 Anti-enteric virus71 (EV71) hexanolactam compounds and its production and use
US9643974B2 (en) 2011-12-12 2017-05-09 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
RU2669695C2 (en) 2011-12-22 2018-10-15 Конекшис Лайф Сайенсиз Пвт. Лтд. Cyclic amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase and uses thereof
RU2705577C2 (en) 2011-12-30 2019-11-08 Ханми Фарм. Ко., Лтд. THIENO[3,2-d]PYRIMIDINE DERIVATIVES WITH PROTEIN KINASE INHIBITORY ACTIVITY
US20150080381A1 (en) 2012-04-12 2015-03-19 Ironwood Pharmaceuticals, Inc. Methods of treating alopecia and acne
MX365776B (en) 2012-04-20 2019-06-12 Kumiai Chemical Industry Co Alkylphenylsulphide derivative and pest control agent.
US9309284B2 (en) 2012-05-02 2016-04-12 Kansas State University Reasearch Foundation Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
US20150110723A1 (en) 2012-05-31 2015-04-23 Emory University Quinazoline derivatives, compositions, and uses related thereto
US10314816B2 (en) 2012-06-08 2019-06-11 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
RU2665462C2 (en) 2012-06-27 2018-08-30 Ф. Хоффманн-Ля Рош Аг 5-azaindazole compounds and methods for use thereof
EP2733143A1 (en) 2012-11-14 2014-05-21 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma receptors ligands
WO2014078214A1 (en) 2012-11-15 2014-05-22 Merck Sharp & Dohme Corp. Azetidine benzimidazoles as pde10 inhibitors
JP2014133739A (en) 2012-12-12 2014-07-24 Dainippon Sumitomo Pharma Co Ltd Pharmaceutical comprising indazole derivative or pyrrolopyridine derivative
ES2684776T3 (en) 2013-01-18 2018-10-04 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as ROCK inhibitors
WO2014172871A1 (en) 2013-04-25 2014-10-30 Syngenta Participations Ag Dihydrobenzofuran derivatives as insecticidal compounds
TWI646092B (en) 2013-08-26 2019-01-01 拜耳作物科學股份有限公司 Compound with insecticidal activity
CN105722833A (en) 2013-09-16 2016-06-29 巴斯夫欧洲公司 Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
AU2014331111B2 (en) 2013-10-04 2018-05-31 Bayer Cropscience Aktiencesellschaft Use of substituted dihydro-oxindolyl sulfonamides, or the salts thereof, for increasing the stress tolerance of plants
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
JP5542237B1 (en) 2013-11-28 2014-07-09 新日鉄住金エンジニアリング株式会社 Gas temperature control method for blast furnace gas dry dust collector and blast furnace gas dry dust collector
JP2017503809A (en) 2014-01-09 2017-02-02 バイエル・ファルマ・アクティエンゲゼルシャフト Amide substituted imidazopyridazine
MX368101B (en) 2014-01-22 2019-09-19 Nabriva Therapeutics Ag 12-epi-pleuromutilins.
NO2699580T3 (en) 2014-01-24 2018-02-24
JP6295702B2 (en) 2014-02-14 2018-03-20 東洋インキScホールディングス株式会社 Reactive monomer and polymerizable composition using the same
WO2015143653A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015155332A1 (en) 2014-04-11 2015-10-15 Boehringer Ingelheim International Gmbh Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one derivatives and their use as mdm2-p53 inhibitors
CN105037367A (en) 2014-04-18 2015-11-11 四川海思科制药有限公司 Amino six-membered ring derivative and application thereof in medicines
TW201623265A (en) 2014-05-09 2016-07-01 奇尼塔公司 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
AU2015276537B2 (en) 2014-06-16 2019-03-14 Fundacion Para La Investigacion Medica Aplicada Novel compounds as dual inhibitors of histone methyltransferases and dna methyltransferases
EP2957561A1 (en) 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
NZ729150A (en) 2014-08-29 2018-02-23 Gilead Sciences Inc Antiretroviral agents
CN111303159A (en) 2014-10-02 2020-06-19 豪夫迈·罗氏有限公司 Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's Tyrosine Kinase (BTK)
CN105566321B (en) 2014-10-29 2020-04-21 广东东阳光药业有限公司 Heteroaromatic compounds and their use in medicine
JP6695875B2 (en) 2014-11-20 2020-05-20 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ Novel 1,3,5-triazine PI3K inhibitor as anticancer agent and method for producing the same
WO2016123576A1 (en) 2015-01-30 2016-08-04 Lieber Institute For Brain Development Comt inhibiting methods and compositions
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502045D0 (en) 2015-02-06 2015-03-25 Ocado Innovation Ltd Device and method for purchasing goods and services
US9409872B1 (en) 2015-02-16 2016-08-09 Mark Quang Nguyen Fumarate compounds, pharmaceutical compositions thereof, and methods of use
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
WO2016204816A1 (en) 2015-06-15 2016-12-22 Ruckus Wireless, Inc. Operator formed network consortiums
GB2548542A (en) 2015-06-16 2017-09-27 Redx Pharma Plc Compounds
FR3037955B1 (en) 2015-06-25 2017-08-18 Univ Nantes POLYDENTATE LIGANDS AND METAL COMPLEXES
EP3328859B1 (en) 2015-07-30 2020-06-03 Boehringer Ingelheim International GmbH 3-((4-isoquinolin-3-yl)methyl)-1h-imidazo[4,5-c]pyridin-2(3h)-one derivatives and related compounds as inhibitors of replication of the respiratory syncytial virus (rsv)
JP6602470B2 (en) 2015-10-09 2019-11-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Spiro [3H-indole-3,2'-pyrrolidin] -2 (1H) -one compounds and derivatives as MDM2-P53 inhibitors
TW201730190A (en) 2015-12-24 2017-09-01 Genentech Inc TDO2 inhibitors
CN106928206B (en) * 2015-12-31 2022-02-18 中国科学院上海药物研究所 Aldehyde compound and its preparation method and use
JP6806413B2 (en) 2016-02-03 2021-01-06 塩野義製薬株式会社 Polycyclic pyridone derivatives and their prodrugs
WO2017155816A1 (en) 2016-03-09 2017-09-14 Merck Sharp & Dohme Corp. Quinazoline compounds useful as m1 receptor positive allosteric modulators
US10166236B2 (en) 2016-03-21 2019-01-01 Perlara Pbc Pharmaceutical formulations comprising substituted pyrazolo[5,1-c]pyrido[4,3-e][1,2,4]triazines for treating lysosomal storage disorders
US9975885B2 (en) 2016-04-28 2018-05-22 Purdue Research Foundation Broad-spectrum non-covalent coronavirus protease inhibitors
TW201808888A (en) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 Modulators of the integrated stress pathway
TW201808903A (en) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 Modulators of the integrated stress pathway
TW202304851A (en) 2016-05-05 2023-02-01 美商嘉來克生命科學有限責任公司 Modulators of the integrated stress pathway
WO2017197377A1 (en) 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection
CN107459511B (en) 2016-06-02 2020-05-29 南开大学 Anti-enterovirus 71(EV71) 4-iminooxazolidine-2-ketone compound and preparation method and application thereof
US20170355708A1 (en) 2016-06-09 2017-12-14 Cadent Therapeutics, Inc. Potassium channel modulators
WO2017222935A1 (en) 2016-06-20 2017-12-28 Kansas State University Research Foundation Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses
JP7061993B2 (en) 2016-07-08 2022-05-02 ライジェル ファーマシューティカルズ, インコーポレイテッド Tyrosine kinase inhibitor
WO2018015818A2 (en) 2016-07-15 2018-01-25 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
WO2018023054A1 (en) 2016-07-28 2018-02-01 Kansas State University Research Foundation Protease transition state inhibitor prodrugs
TW201817714A (en) 2016-08-30 2018-05-16 英商葛蘭素史密斯克藍智慧財產權有限公司 Compounds that inhibit 3C and 3CL proteases and methods of use thereof
CN108069984B (en) 2016-11-18 2021-02-05 沈阳中化农药化工研发有限公司 Substituted five-membered heterocyclic compound containing pyrimido ring and preparation method and application thereof
WO2018108627A1 (en) 2016-12-12 2018-06-21 Bayer Cropscience Aktiengesellschaft Use of substituted indolinylmethyl sulfonamides, or the salts thereof for increasing the stress tolerance of plants
EP3342779A1 (en) 2016-12-27 2018-07-04 Zedira GmbH Inhibitors of transglutaminases
US20180289676A1 (en) 2017-03-30 2018-10-11 Saint Louis University Compounds and methods targeting gper in cancer
CN108690043B (en) 2017-04-11 2019-10-18 东莞东阳光科研发有限公司 Quinoline derivatives and its preparation method and application
EP3630775B1 (en) 2017-05-31 2022-12-14 ChemoCentryx, Inc. 6-5 FUSED RINGS AS C5a INHIBITORS
EP3642187A1 (en) 2017-06-19 2020-04-29 Basf Se 2-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]aryloxy](thio)acetamides for combating phytopathogenic fungi
JP2020152641A (en) 2017-07-07 2020-09-24 国立研究開発法人理化学研究所 Novel compound having lysine-specific demethylating enzyme 1 inhibitory activity, method for producing the same, and use of the same
WO2019068726A1 (en) 2017-10-02 2019-04-11 Scientist Of Fortune S.A. Cellular transport system for transferring a sulfonic acid construct carrying a cargo into the cytoplasm of a cell
WO2019075386A1 (en) 2017-10-13 2019-04-18 The Regents Of The University Of California Mtorc1 modulators
WO2019086474A1 (en) 2017-10-31 2019-05-09 Syngenta Participations Ag Pesticidally active mesoionics heterocyclic compounds
WO2019089412A1 (en) 2017-11-01 2019-05-09 Merck Sharp & Dohme Corp. Novel substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
WO2019104070A1 (en) 2017-11-21 2019-05-31 Nanostring Technologies, Inc. O-nitrobenzyl photocleavable bifunctional linker
US20200305429A1 (en) 2017-11-23 2020-10-01 Basf Se Herbicidal phenylethers
WO2019129121A1 (en) 2017-12-28 2019-07-04 Rpxds Co., Ltd Derivatives of phenylmethanone as fto inhibitors
CN109988109B (en) 2017-12-29 2020-12-29 广东东阳光药业有限公司 Amine compound for inhibiting SSAO/VAP-1 and application thereof
GB201801355D0 (en) 2018-01-26 2018-03-14 Enterprise Therapeutics Ltd Compounds
US11884645B2 (en) 2018-03-02 2024-01-30 Inflazome Limited Sulfonyl acetamides as NLRP3 inhibitors
US20190282703A1 (en) 2018-03-13 2019-09-19 Mavupharma, Inc. Ectonucleotide pyrophosphatase-phosphodiesterase (enpp) conjugates and uses thereof
EP3775186A4 (en) 2018-03-30 2022-01-05 AbbVie Inc. Ectonucleotide pyrophosphate-phosphodiesterase (enpp) conjugates and uses thereof
WO2019201432A1 (en) 2018-04-17 2019-10-24 Zedira Gmbh Inhibitors of blood coagulation factor xiii
WO2019204816A1 (en) 2018-04-20 2019-10-24 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers
CN110054596B (en) 2018-05-29 2023-03-31 沈阳化工大学 Substituted oxadiazole compound and application thereof
WO2019232245A1 (en) 2018-06-01 2019-12-05 The Regents Of The University Of California A method for fluorinated ring-opening of a substrate
EP3820500A4 (en) 2018-07-13 2022-04-13 Teqla Therapeutics, Inc. Use of bcl6 inhibitors for treating autoimmune diseases
RU2761824C2 (en) 2018-08-03 2021-12-13 Закрытое Акционерное Общество "Биокад" Cdk8/19 inhibitors
CN110818691A (en) 2018-08-09 2020-02-21 中国科学院上海药物研究所 Ketoamide compound and preparation method, pharmaceutical composition and application thereof
WO2020037166A1 (en) 2018-08-16 2020-02-20 Cornell University Rhenium complexes and methods of use for treating cancer
CA3110877A1 (en) 2018-08-27 2020-03-05 Spinogenix, Inc. Fascin binding compounds for spinogenesis
US10696659B2 (en) 2018-11-21 2020-06-30 Accutar Biotechnology Inc. Compounds having estrogen receptor alpha degradation activity and uses thereof
EP3656762A1 (en) 2018-11-26 2020-05-27 Instituto Biomar S.A. Compounds for the treatment of nf-kb-related diseases or disorders
CA3123902A1 (en) 2019-01-03 2020-07-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for increasing transcription factor eb polypeptide levels
EP3927433A1 (en) 2019-02-18 2021-12-29 Genentech, Inc. Pyrido-pyrimidinyl compounds and methods of use
WO2020169682A1 (en) 2019-02-19 2020-08-27 Yncrea Hauts De France Hydrazide derivatives and their specific use as antibacterial agents by controlling acinetobacter baumannii bacterium
CN110105348A (en) 2019-03-08 2019-08-09 南开大学 The preparation and purposes of novel michael acceptor class enteric virus71 type inhibitor
CN113518779B (en) 2019-03-28 2024-03-15 江苏恒瑞医药股份有限公司 Thieno heterocyclic derivative, preparation method and medical application thereof
AU2020289560A1 (en) 2019-06-05 2021-12-23 Emory University Peptidomimetics for the treatment of coronavirus and picornavirus infections
KR20220151038A (en) * 2020-03-31 2022-11-11 피닉스 바이오테크놀러지 인코포레이티드. Compositions for preventing coronavirus infection
CR20210563A (en) * 2020-04-05 2022-01-24 Pfizer Compounds and methods for the treatment of covid-19
EP4132944A1 (en) * 2020-04-10 2023-02-15 Cocrystal Pharma, Inc. Inhibitors of norovirus and coronavirus replication
US11124497B1 (en) 2020-04-17 2021-09-21 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
KR20230040386A (en) 2020-06-09 2023-03-22 파르데스 바이오사이언시스, 인크. Inhibitors of cysteine proteases and methods of use thereof
US11174231B1 (en) 2020-06-09 2021-11-16 Pardes Biosciences, Inc. Inhibitors of cysteine proteases and methods of use thereof
JP2023530267A (en) 2020-06-10 2023-07-14 アリゴス セラピューティクス インコーポレイテッド Antiviral compounds for treating coronavirus, picornavirus and norovirus infections
CN116348477A (en) 2020-07-20 2023-06-27 英安塔制药有限公司 Functionalized peptides as antiviral agents

Similar Documents

Publication Publication Date Title
AU2021266232A1 (en) Nitrile-containing antiviral compounds
ZA202204779B (en) Nitrile-containing antiviral compounds
EP4037688A4 (en) Antiviral heterocyclic compounds
EP4061364A4 (en) Heteroaryl compounds
EP4021438A4 (en) Patentiflorin a analogs as antiviral agents
EP3950778A4 (en) Fluoropolyether-group-containing compound
EP3908285A4 (en) Organic compounds
EP4072554A4 (en) Organic compound
EP3870183A4 (en) Formulations of antiviral compounds
EP3733682A4 (en) Novel allulose-derived compound
AU2021904268A0 (en) Compounds
AU2021904269A0 (en) Compounds
AU2021904274A0 (en) Compounds
AU2021903120A0 (en) Compounds
AU2021901886A0 (en) Compounds
AU2020902630A0 (en) Compounds
AU2021900149A0 (en) Antiviral combination
AU2020902199A0 (en) Novel compounds
AU2021903608A0 (en) Antiviral agent
AU2021903323A0 (en) Antiviral agent
EP4151230A4 (en) Antiviral agent
AU2020902244A0 (en) Compound
AU2021900380A0 (en) Coating compounds
AU2020903513A0 (en) Fender
AU2020903936A0 (en) Coating compounds