AU2021242353A1 - Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells - Google Patents
Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells Download PDFInfo
- Publication number
- AU2021242353A1 AU2021242353A1 AU2021242353A AU2021242353A AU2021242353A1 AU 2021242353 A1 AU2021242353 A1 AU 2021242353A1 AU 2021242353 A AU2021242353 A AU 2021242353A AU 2021242353 A AU2021242353 A AU 2021242353A AU 2021242353 A1 AU2021242353 A1 AU 2021242353A1
- Authority
- AU
- Australia
- Prior art keywords
- ehgt
- expression construct
- syfp2
- bghpa
- artificial expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063001159P | 2020-03-27 | 2020-03-27 | |
| US63/001,159 | 2020-03-27 | ||
| PCT/US2021/024525 WO2021195591A2 (en) | 2020-03-27 | 2021-03-26 | Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2021242353A1 true AU2021242353A1 (en) | 2022-11-03 |
Family
ID=77890746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021242353A Pending AU2021242353A1 (en) | 2020-03-27 | 2021-03-26 | Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230117172A1 (https=) |
| EP (1) | EP4127182A4 (https=) |
| JP (2) | JP7749577B2 (https=) |
| AU (1) | AU2021242353A1 (https=) |
| CA (1) | CA3173609A1 (https=) |
| WO (1) | WO2021195591A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3207224A1 (en) * | 2021-02-02 | 2022-08-11 | Bryan GORE | Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes |
| WO2023060112A1 (en) * | 2021-10-05 | 2023-04-13 | Allen Institute | Artificial expression constructs for modulating gene expression in the cerebellum and a secondary cell type |
| JP2025520385A (ja) * | 2022-06-13 | 2025-07-03 | アレン インスティテュート | 中枢神経系の非神経細胞において遺伝子発現を調節するための人工発現コンストラクト |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6602680B2 (en) | 2000-07-14 | 2003-08-05 | The Regents Of The University Of California | Production of gabaergic cells |
| US20060127358A1 (en) | 2002-05-01 | 2006-06-15 | Nicholas Muzyczka | Raav expression systems and methods for enhancing transduction of mammalian neural cells |
| US20080039413A1 (en) * | 2003-10-21 | 2008-02-14 | Morris David W | Novel compositions and methods in cancer |
| EP4154903A1 (en) * | 2008-04-22 | 2023-03-29 | Vib Vzw | Liver-specific nucleic acid regulatory elements and methods and use thereof |
| WO2013155222A2 (en) * | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| CN110546257B (zh) * | 2017-03-17 | 2024-03-01 | 阿德夫拉姆生物技术股份有限公司 | 用于增强基因表达的组合物和方法 |
| WO2019068854A1 (en) * | 2017-10-06 | 2019-04-11 | Ospedale San Raffaele S.R.L. | GENE THERAPY OF NEURODEGENERATIVE DISEASES USING VAA VECTORS |
| US11364309B2 (en) | 2017-11-10 | 2022-06-21 | Norwegian University Of Science And Technology (Ntnu) | Neuronal enhancers |
| AU2019253700B2 (en) * | 2018-04-09 | 2025-08-14 | Allen Institute | Rescuing voltage-gated sodium channel function in inhibitory neurons |
-
2021
- 2021-03-26 CA CA3173609A patent/CA3173609A1/en active Pending
- 2021-03-26 US US17/907,385 patent/US20230117172A1/en active Pending
- 2021-03-26 EP EP21774065.3A patent/EP4127182A4/en active Pending
- 2021-03-26 WO PCT/US2021/024525 patent/WO2021195591A2/en not_active Ceased
- 2021-03-26 AU AU2021242353A patent/AU2021242353A1/en active Pending
- 2021-03-26 JP JP2022558098A patent/JP7749577B2/ja active Active
-
2025
- 2025-09-24 JP JP2025157795A patent/JP2026001073A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023518980A (ja) | 2023-05-09 |
| CA3173609A1 (en) | 2021-09-30 |
| EP4127182A4 (en) | 2024-07-31 |
| WO2021195591A2 (en) | 2021-09-30 |
| US20230117172A1 (en) | 2023-04-20 |
| JP7749577B2 (ja) | 2025-10-06 |
| JP2026001073A (ja) | 2026-01-06 |
| EP4127182A2 (en) | 2023-02-08 |
| WO2021195591A3 (en) | 2021-11-25 |
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