AU2020278703A1 - Methods and compositions for treating liver disorders - Google Patents

Methods and compositions for treating liver disorders Download PDF

Info

Publication number
AU2020278703A1
AU2020278703A1 AU2020278703A AU2020278703A AU2020278703A1 AU 2020278703 A1 AU2020278703 A1 AU 2020278703A1 AU 2020278703 A AU2020278703 A AU 2020278703A AU 2020278703 A AU2020278703 A AU 2020278703A AU 2020278703 A1 AU2020278703 A1 AU 2020278703A1
Authority
AU
Australia
Prior art keywords
subject
composition
liver
microbial
alt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2020278703A
Other languages
English (en)
Inventor
James Bullard
Colleen Cutcliffe
John Eid
Orville Kolterman
Fanny PERRAUDEAU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pendulum Therapeutics Inc
Original Assignee
Pendulum Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pendulum Therapeutics Inc filed Critical Pendulum Therapeutics Inc
Publication of AU2020278703A1 publication Critical patent/AU2020278703A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU2020278703A 2019-05-21 2020-05-20 Methods and compositions for treating liver disorders Abandoned AU2020278703A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962850773P 2019-05-21 2019-05-21
US62/850,773 2019-05-21
PCT/US2020/033870 WO2020236979A1 (en) 2019-05-21 2020-05-20 Methods and compositions for treating liver disorders

Publications (1)

Publication Number Publication Date
AU2020278703A1 true AU2020278703A1 (en) 2022-01-27

Family

ID=73458208

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020278703A Abandoned AU2020278703A1 (en) 2019-05-21 2020-05-20 Methods and compositions for treating liver disorders

Country Status (10)

Country Link
US (1) US20220211780A1 (cg-RX-API-DMAC10.html)
EP (1) EP3973047A4 (cg-RX-API-DMAC10.html)
JP (1) JP2022533672A (cg-RX-API-DMAC10.html)
KR (1) KR20220011683A (cg-RX-API-DMAC10.html)
CN (1) CN113993529A (cg-RX-API-DMAC10.html)
AU (1) AU2020278703A1 (cg-RX-API-DMAC10.html)
CA (1) CA3140096A1 (cg-RX-API-DMAC10.html)
SG (1) SG11202112515RA (cg-RX-API-DMAC10.html)
WO (1) WO2020236979A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA202110111B (cg-RX-API-DMAC10.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4529950A3 (en) 2014-10-31 2025-08-20 Pendulum Therapeutics, Inc. Methods and compositions relating to microbial treatment
WO2019046646A1 (en) 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
CN113164526A (zh) 2018-07-19 2021-07-23 潘德勒姆治疗公司 用于微生物植入的方法和组合物
EP3973047A4 (en) * 2019-05-21 2023-01-11 Pendulum Therapeutics, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF LIVER DISEASES
NL2030011B1 (en) * 2021-12-03 2023-06-20 Caelus Pharmaceuticals B V Prevention or treatment of hepatic steatosis
EP4467148A4 (en) * 2022-01-20 2025-04-23 Korea Institute of Science and Technology Composition for prevention, amelioration or treatment of non-alcoholic fatty liver disease, comprising extracellular vesicles derived from roseburia spp. or bifidobacterium spp
CN117599092B (zh) * 2024-01-23 2024-04-26 南方医科大学南方医院 生孢梭菌在制备预防和/或治疗肝脏疾病的药物中的应用
CN118526527A (zh) * 2024-03-19 2024-08-23 华中科技大学同济医学院附属协和医院 益生菌混合液在制备预防或治疗apap诱导肝损伤药物中的应用
KR102679094B1 (ko) * 2024-04-24 2024-06-27 충남대학교 산학협력단 항비만 효능을 지닌 한국인 마이크로바이옴 유래 클로스트리디움 부티리쿰 균주 및 이의 용도
CN119639633A (zh) * 2025-02-18 2025-03-18 杭州师范大学附属医院(杭州市第二人民医院) 一种治疗非酒精性脂肪肝的酵母菌益生菌复合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4529950A3 (en) * 2014-10-31 2025-08-20 Pendulum Therapeutics, Inc. Methods and compositions relating to microbial treatment
JP7311267B2 (ja) * 2016-01-11 2023-07-19 エゲティス・セラピューティクス・アーベー 急性肝不全及び他の肝毒性状態を治療及び／又はこれらから保護するための方法及び製剤
WO2018106844A1 (en) * 2016-12-06 2018-06-14 Whole Biome Inc. Methods and compositions relating to isolated and purified microbes
WO2019046646A1 (en) * 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
CN111527195B (zh) * 2017-09-28 2023-11-03 Ko生物技术有限公司 用产生短链脂肪酸的肠道细菌群落的改变诊断和治疗酒精性肝病的组合物
JP2022502373A (ja) * 2018-09-24 2022-01-11 ペンデュラム セラピューティクス， インコーポレイテッド 微生物組成物および使用方法
EP3973047A4 (en) * 2019-05-21 2023-01-11 Pendulum Therapeutics, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF LIVER DISEASES

Also Published As

Publication number Publication date
JP2022533672A (ja) 2022-07-25
US20220211780A1 (en) 2022-07-07
EP3973047A1 (en) 2022-03-30
EP3973047A4 (en) 2023-01-11
WO2020236979A1 (en) 2020-11-26
CN113993529A (zh) 2022-01-28
CA3140096A1 (en) 2020-11-26
ZA202110111B (en) 2024-04-24
KR20220011683A (ko) 2022-01-28
SG11202112515RA (en) 2021-12-30

Similar Documents

Publication Publication Date Title
US20220211780A1 (en) Methods And Compositions For Treating Liver Disorders
US11213556B2 (en) Methods and compositions relating to microbial treatment and diagnosis of disorders
US20210213078A1 (en) Microbial compositions and methods of use
EP2481299B1 (en) Bifidobacterium bifidum strains for application in gastrointestinal diseases
AU2016359178A1 (en) Designed bacterial compositions
TWI565471B (zh) Oral use of DNA damage repair promoters and elastase activity inhibitors
KR20170053733A (ko) 프리바이오틱 제제 및 사용 방법
US12343360B2 (en) Methods and compositions for microbial engraftment
CN106974262A (zh) 肠道益生杆菌在治疗和预防肥胖及其相关疾病中的应用
AU2020257267A1 (en) Compositions including novel microbes with enhanced persistence, synergistic combinations of novel microbes and prebiotics, and methods for the isolation of such microbes
CN106994134A (zh) 肠道益生菌在预防和/或治疗糖尿病及其相关疾病中的应用
JP2018532380A (ja) 腸内細菌の酪酸桿菌（Ｂｕｔｙｒｉｂａｃｔｅｒ ｉｎｔｅｓｔｉｎｉ）およびその使用
CN106974939B (zh) 厚壁菌类益生菌在治疗和预防肥胖及其相关疾病中的应用
CN106974940B (zh) 厚壁菌类益生菌在治疗和预防肥胖及其相关疾病中的应用
CN120866165A (zh) 一株鼠李糖乳酪杆菌及在干预尿酸合成中的应用
CN121950613A (zh) 一株普通拟杆菌af107-22及其应用
HK1239464A (en) Application of intestinal probiotics in treating and preventing obesity and related diseases thereof
HK1239564A (en) Application of thick-wall fungus probiotics in treatment and prevention of obesity and related diseases
HK1240096A (en) Application of intestinal probiotics in preventing and/or treating diabetes and related diseases thereof
HK1240096A1 (en) Application of intestinal probiotics in preventing and/or treating diabetes and related diseases thereof
HK1239564A1 (en) Application of thick-wall fungus probiotics in treatment and prevention of obesity and related diseases
HK1240143A (en) Application of thick-wall fungus probiotics in preventing and/or treating diabetes and related diseases thereof

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period