AU2020233788A1 - Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy - Google Patents

Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy Download PDF

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Publication number
AU2020233788A1
AU2020233788A1 AU2020233788A AU2020233788A AU2020233788A1 AU 2020233788 A1 AU2020233788 A1 AU 2020233788A1 AU 2020233788 A AU2020233788 A AU 2020233788A AU 2020233788 A AU2020233788 A AU 2020233788A AU 2020233788 A1 AU2020233788 A1 AU 2020233788A1
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Prior art keywords
vims
replicon rna
synthetic oncolytic
synthetic
self
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AU2020233788A
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Inventor
Yizhou Dong
Darrell J. Irvine
Yingzhong Li
Noor MOMIN
Ron Weiss
Karl Dane Wittrup
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Massachusetts Institute of Technology
Ohio State Innovation Foundation
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Massachusetts Institute of Technology
Ohio State Innovation Foundation
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Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, OHIO STATE INNOVATION FOUNDATION reassignment MASSACHUSETTS INSTITUTE OF TECHNOLOGY Request for Assignment Assignors: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE OHIO STATE UNIVERSITY
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2020233788A 2019-03-08 2020-01-10 Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy Pending AU2020233788A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962815611P 2019-03-08 2019-03-08
US62/815,611 2019-03-08
PCT/US2020/013069 WO2020185293A1 (en) 2019-03-08 2020-01-10 Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy

Publications (1)

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AU2020233788A1 true AU2020233788A1 (en) 2021-10-07

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AU2020233788A Pending AU2020233788A1 (en) 2019-03-08 2020-01-10 Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy

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US (3) US11717548B2 (enExample)
EP (2) EP3934673B1 (enExample)
JP (2) JP7561134B2 (enExample)
KR (2) KR20250171410A (enExample)
CN (1) CN113966221B (enExample)
AU (1) AU2020233788A1 (enExample)
BR (1) BR112021017637A8 (enExample)
CA (1) CA3132714A1 (enExample)
CO (1) CO2021013417A2 (enExample)
DK (1) DK3934673T3 (enExample)
ES (1) ES3066636T3 (enExample)
FI (1) FI3934673T3 (enExample)
IL (1) IL285963A (enExample)
MX (1) MX2021010808A (enExample)
MY (1) MY207334A (enExample)
PH (1) PH12021552145A1 (enExample)
PT (1) PT3934673T (enExample)
SG (1) SG11202109514VA (enExample)
WO (1) WO2020185293A1 (enExample)

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CN121971599A (zh) 2019-02-25 2026-05-05 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
KR20250171410A (ko) * 2019-03-08 2025-12-08 메사추세츠 인스티튜트 오브 테크놀로지 합성 종양용해성 lnp-레플리콘 rna 및 암 면역요법을 위한 용도
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
CN113509542A (zh) * 2021-04-20 2021-10-19 嘉晨西海(杭州)生物技术有限公司 一种基于mRNA的表达白介素12针对肿瘤的药物及其制备方法
CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
IL316186A (en) 2022-04-26 2024-12-01 Strand Therapeutics Inc Lipid nanoparticles containing Venezuelan equine encephalitis (VEE) replicon and uses thereof
CN115227674B (zh) * 2022-08-05 2023-07-04 武汉滨会生物科技股份有限公司 包封的溶瘤病毒遗传物质及其应用
JP2026502453A (ja) * 2023-01-12 2026-01-23 バヴァリアン・ノルディック・アクティーゼルスカブ がんワクチンのための組み換え改変ｓａＲＮＡ（ＶＲＰ）
WO2024211865A2 (en) * 2023-04-07 2024-10-10 Omega Therapeutics, Inc. Lipids and lipid-like compounds for therapeutic lipid nanoparticle (lnp) delivery
CN118147171B (zh) * 2024-03-08 2024-12-06 上海复诺健生物科技有限公司 具有增强的外源基因表达水平的自扩增mRNA核酸序列
KR20260046366A (ko) 2023-07-25 2026-04-07 스트랜드 세러퓨틱스 인코포레이티드 마이크로 rna 비표적화 센서를 포함하는 폴리뉴클레오타이드 및 이의 용도
WO2025087372A1 (zh) * 2023-10-27 2025-05-01 上海元宋生物技术有限公司 溶瘤病毒及其用途
CN119479778B (zh) * 2024-10-16 2025-04-25 北京悦康科创医药科技股份有限公司 一种lnp转染效率预测模型构建方法及装置
CN121081290B (zh) * 2025-11-12 2026-03-10 佑嘉(杭州)生物医药科技有限公司 一种毛囊靶向递送系统及生发防脱化妆品

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Publication number Publication date
BR112021017637A8 (pt) 2022-08-16
KR20250171410A (ko) 2025-12-08
WO2020185293A1 (en) 2020-09-17
KR102889984B1 (ko) 2025-11-25
CN113966221B (zh) 2026-03-31
DK3934673T3 (da) 2026-04-07
US20200281994A1 (en) 2020-09-10
PH12021552145A1 (en) 2022-08-31
ES3066636T3 (en) 2026-05-13
BR112021017637A2 (enExample) 2021-11-09
SG11202109514VA (en) 2021-09-29
CN113966221A (zh) 2022-01-21
FI3934673T3 (fi) 2026-03-31
CA3132714A1 (en) 2020-09-17
MX2021010808A (es) 2021-12-15
MY207334A (en) 2025-02-19
KR20220006041A (ko) 2022-01-14
US20240024394A1 (en) 2024-01-25
US20260061013A1 (en) 2026-03-05
CO2021013417A2 (es) 2022-01-17
PT3934673T (pt) 2026-04-07
JP7561134B2 (ja) 2024-10-03
EP3934673A1 (en) 2022-01-12
US12383589B2 (en) 2025-08-12
JP2022524391A (ja) 2022-05-02
IL285963A (en) 2021-10-31
EP4729621A2 (en) 2026-04-22
US11717548B2 (en) 2023-08-08
EP3934673B1 (en) 2026-01-07
JP2025011109A (ja) 2025-01-23

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