AU2020209184A1 - A rodent model of mood disorders - Google Patents

A rodent model of mood disorders Download PDF

Info

Publication number
AU2020209184A1
AU2020209184A1 AU2020209184A AU2020209184A AU2020209184A1 AU 2020209184 A1 AU2020209184 A1 AU 2020209184A1 AU 2020209184 A AU2020209184 A AU 2020209184A AU 2020209184 A AU2020209184 A AU 2020209184A AU 2020209184 A1 AU2020209184 A1 AU 2020209184A1
Authority
AU
Australia
Prior art keywords
gpr156
rodent
gene
human
humanized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2020209184A
Other languages
English (en)
Inventor
Nicole ALESSANDRI-HABER
Robert Breese
Susannah BRYDGES
Susan D. Croll
Meghan DRUMMOND SAMUELSON
Claudia GONZAGA-JAUREGUI
Charleen Hunt
Ka-Man Venus Lai
Andrew J. Murphy
Jose Rojas
Brian Zambrowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of AU2020209184A1 publication Critical patent/AU2020209184A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2020209184A 2019-01-17 2020-01-16 A rodent model of mood disorders Abandoned AU2020209184A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962793523P 2019-01-17 2019-01-17
US62/793,523 2019-01-17
US201962899849P 2019-09-13 2019-09-13
US62/899,849 2019-09-13
PCT/US2020/013801 WO2020150426A1 (en) 2019-01-17 2020-01-16 A rodent model of mood disorders

Publications (1)

Publication Number Publication Date
AU2020209184A1 true AU2020209184A1 (en) 2021-07-08

Family

ID=69529068

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020209184A Abandoned AU2020209184A1 (en) 2019-01-17 2020-01-16 A rodent model of mood disorders

Country Status (11)

Country Link
US (2) US11470828B2 (https=)
EP (1) EP3911154A1 (https=)
JP (1) JP7509786B2 (https=)
KR (1) KR20210116480A (https=)
CN (1) CN113423266A (https=)
AU (1) AU2020209184A1 (https=)
CA (1) CA3124514A1 (https=)
IL (1) IL284078A (https=)
MX (1) MX2021008291A (https=)
SG (1) SG11202106423PA (https=)
WO (1) WO2020150426A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7509786B2 (ja) * 2019-01-17 2024-07-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 気分障害の齧歯類モデル
CN116676334B (zh) * 2023-02-08 2025-05-27 深圳大学 抑郁症动物模型的构建方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004137A1 (en) 1999-07-09 2001-01-18 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the osteoclastogenesis inhibitory factor gene
ATE437948T1 (de) * 2000-06-20 2009-08-15 Bionomics Ltd Mutation, welche mit epilepsie assoziiert ist
EP1581648A2 (en) 2002-09-09 2005-10-05 Nura, Inc. G protein coupled receptors and uses thereof
US20040216177A1 (en) 2003-04-25 2004-10-28 Otsuka Pharmaceutical Co., Ltd. Congenic rats containing a mutant GPR10 gene
ES2463476T3 (es) 2004-10-19 2014-05-28 Regeneron Pharmaceuticals, Inc. Método para generar un ratón homocigótico para una modificación genética
EP1940876A1 (en) 2005-10-28 2008-07-09 Takeda Cambridge Limited Gpr 26 g-protein coupled receptor
EP2091556B1 (en) * 2006-11-15 2018-07-25 Omeros Corporation Non-human animal comprising a mutation in the sreb2/gpr85 gene as animal model of metabolic disease
US8518392B2 (en) 2009-08-14 2013-08-27 Regeneron Pharmaceuticals, Inc. Promoter-regulated differentiation-dependent self-deleting cassette
EP4502152A3 (en) * 2009-10-06 2025-04-30 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
US20160058891A1 (en) 2011-11-01 2016-03-03 Roche Glycart Ag In vivo adcc model
MX384291B (es) 2013-02-20 2025-03-14 Regeneron Pharma Modificación genética de ratas.
DK3456831T3 (da) 2013-04-16 2021-09-06 Regeneron Pharma Målrettet modifikation af rottegenom
DK3422845T3 (da) 2016-02-29 2021-08-30 Regeneron Pharma Gnavere med et humaniseret tmprss-gen
EP3491014B1 (en) 2016-07-28 2023-04-05 Regeneron Pharmaceuticals, Inc. Allele-specific primer or probe hybridized to a nucleic acid molecule encoding a gpr156 variant
JP7509786B2 (ja) * 2019-01-17 2024-07-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 気分障害の齧歯類モデル

Also Published As

Publication number Publication date
CN113423266A (zh) 2021-09-21
IL284078A (en) 2021-08-31
MX2021008291A (es) 2021-08-05
US20230123787A1 (en) 2023-04-20
EP3911154A1 (en) 2021-11-24
JP7509786B2 (ja) 2024-07-02
JP2022517101A (ja) 2022-03-04
KR20210116480A (ko) 2021-09-27
CA3124514A1 (en) 2020-07-23
SG11202106423PA (en) 2021-07-29
WO2020150426A1 (en) 2020-07-23
US11470828B2 (en) 2022-10-18
US20200229409A1 (en) 2020-07-23

Similar Documents

Publication Publication Date Title
US20230123787A1 (en) Rodent model of mood disorders
Witkin et al. Constitutive deletion of the serotonin-7 (5-HT7) receptor decreases electrical and chemical seizure thresholds
JP4468429B2 (ja) ニューロンニコチン性アセチルコリン受容体のβ２−サブユニットの調節配列及びこれをコードする配列を含むゲノムＤＮＡ断片、及びこれらの断片又は突然変異断片を用いて作製されたトランスジェニック動物
Vettori et al. Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: a new model for Charcot-Marie-Tooth type 2A neuropathy
JPH08506240A (ja) ヒトセロトニン受容体（５−ｈｔ▲４ｂ▼）をコードするｄｎａ及びその使用
CN114480491A (zh) 一种grin2a基因突变认知障碍小鼠模型的构建和应用
Sano et al. X11-like protein deficiency is associated with impaired conflict resolution in mice
EP1353549A2 (en) Mice heterozygous for wfs1 gene as mouse models for depression
Seyfried et al. Experimental models of epilepsy
O’Sullivan et al. Dopamine receptors and behavior: from psychopharmacology to mutant models
JP5054519B2 (ja) Ａｄａｍ１１遺伝子が破壊された非ヒト遺伝子破壊動物
JP5079839B2 (ja) 本態性振戦症が強化されたマウスモデル及びその製造方法
Ross Generation and characterization of mice lacking the α4 nicotinic receptor subunit
US6326526B1 (en) Melatonin receptor-deficient mice and uses thereof
US20050010967A1 (en) SK3-1B GFP transgenic mouse model for spinocerebellar ataxia and hyperexcitable behavior
US9139638B2 (en) Mouse model of cholinergic dysfunction to evaluate cognitive enhancers and drugs that improve myasthenia
WO2008024356A1 (en) Animal model of cholinergic dysfunction to evaluate cognitive enhancers and drugs that improve myasthenia
Kruse A Role for MPDZ in ethanol withdrawal but not binge-like ethanol drinking
Sanyal Characterization of dopamine receptor function using different transgenic and knockout animal models
US20080070237A1 (en) Npas3 Mutant Mice and Uses for Screening and Testing Therapies for Schizophrenia and Related Neurological Disorders
Camera Ggad
JPWO2007043589A1 (ja) 統合失調症モデル動物
Khericha Genetic Analysis of Sleep in Drosophila Melanogaster
US20090187996A1 (en) Ion Channel
CA2523537A1 (en) Pathophysiology associated with a single gene (mass1) mutation underlying the robust audiogenic seizure phenotype in frings mice

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application