AU2019394875A1 - Artificial antigen presenting cells including HLA-E and HLA-G molecules and methods of use - Google Patents

Artificial antigen presenting cells including HLA-E and HLA-G molecules and methods of use Download PDF

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Publication number
AU2019394875A1
AU2019394875A1 AU2019394875A AU2019394875A AU2019394875A1 AU 2019394875 A1 AU2019394875 A1 AU 2019394875A1 AU 2019394875 A AU2019394875 A AU 2019394875A AU 2019394875 A AU2019394875 A AU 2019394875A AU 2019394875 A1 AU2019394875 A1 AU 2019394875A1
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Australia
Prior art keywords
cell
polypeptide
exogenous
aapc
cells
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Abandoned
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AU2019394875A
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English (en)
Inventor
Tiffany Fen-Yi Chen
Regina Sophia Salvat
Thomas Joseph WICKHAM
Xuqing Zhang
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Rubius Therapeutics Inc
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Rubius Therapeutics Inc
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Publication of AU2019394875A1 publication Critical patent/AU2019394875A1/en
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0641Erythrocytes
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/18Erythrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46433Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747Apoptosis related proteins
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/605MHC molecules or ligands thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
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    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/50Cell markers; Cell surface determinants
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    • C12N2510/00Genetically modified cells

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  • Bioinformatics & Cheminformatics (AREA)
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  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU2019394875A 2018-12-03 2019-12-03 Artificial antigen presenting cells including HLA-E and HLA-G molecules and methods of use Abandoned AU2019394875A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862774857P 2018-12-03 2018-12-03
US62/774,857 2018-12-03
PCT/US2019/064303 WO2020117852A1 (en) 2018-12-03 2019-12-03 Artificial antigen presenting cells including hla-e and hla-g molecules and methods of use

Publications (1)

Publication Number Publication Date
AU2019394875A1 true AU2019394875A1 (en) 2021-06-17

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AU2019394875A Abandoned AU2019394875A1 (en) 2018-12-03 2019-12-03 Artificial antigen presenting cells including HLA-E and HLA-G molecules and methods of use

Country Status (7)

Country Link
US (1) US20200172597A1 (zh)
EP (1) EP3891269A1 (zh)
JP (1) JP2022513705A (zh)
CN (1) CN113366102A (zh)
AU (1) AU2019394875A1 (zh)
CA (1) CA3121258A1 (zh)
WO (1) WO2020117852A1 (zh)

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US11020435B2 (en) * 2017-02-17 2021-06-01 Rubius Therapeutics, Inc. Functionalized erythroid cells
JP2023545499A (ja) * 2020-10-15 2023-10-30 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 共培養システムによる巨核球と血小板の産生
CN112794901B (zh) * 2021-01-08 2022-01-04 南通大学附属医院 一种抗smim15单克隆抗体及其应用
WO2022192789A1 (en) * 2021-03-12 2022-09-15 Synthego Corporation Genetically modified cells expressing antigen-containing fusion proteins and uses thereof
WO2022236102A1 (en) * 2021-05-07 2022-11-10 Institute For Systems Biology Single chain trimer mhc class i nucleic acids and proteins and methods of use
WO2022251367A1 (en) * 2021-05-27 2022-12-01 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g

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US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
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Also Published As

Publication number Publication date
EP3891269A1 (en) 2021-10-13
CN113366102A (zh) 2021-09-07
US20200172597A1 (en) 2020-06-04
CA3121258A1 (en) 2020-06-11
JP2022513705A (ja) 2022-02-09
WO2020117852A1 (en) 2020-06-11

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